Enhancing sunscreen DNA and photo-ageing protection. Skin damage from UV exposure is costly for individuals and the community, particularly in Australia, where the population has predominantly fair skin. While public campaigns to persuade the population to use sun protection and avoidance have been useful, this project will be the first to extend this approach to deliver a way to reduce sun damage from any UV exposure that does nevertheless occur, by incorporating the active agents into topical ....Enhancing sunscreen DNA and photo-ageing protection. Skin damage from UV exposure is costly for individuals and the community, particularly in Australia, where the population has predominantly fair skin. While public campaigns to persuade the population to use sun protection and avoidance have been useful, this project will be the first to extend this approach to deliver a way to reduce sun damage from any UV exposure that does nevertheless occur, by incorporating the active agents into topical sunscreens or creams for after-sun use. The project will also build infrastructure for translational research on photo-damage, combining world-class facilities for this research with advanced formulation and manufacturing operations.Read moreRead less
Improving road safety: advanced hybrid vehicle-based technology for monitoring driver drowsiness. Innovative technology geared towards reducing road accidents and fatalities (for improving public health) will constitute major socio-economic benefit to Australia. The Australian Transport Safety Bureau notes fatigue as a major cause of road accidents (2006). The World Health Organisation dedicated World Health Day 2004 to road safety and emphasized the importance of combating fatigue ('Road Safety ....Improving road safety: advanced hybrid vehicle-based technology for monitoring driver drowsiness. Innovative technology geared towards reducing road accidents and fatalities (for improving public health) will constitute major socio-economic benefit to Australia. The Australian Transport Safety Bureau notes fatigue as a major cause of road accidents (2006). The World Health Organisation dedicated World Health Day 2004 to road safety and emphasized the importance of combating fatigue ('Road Safety is no Accident'). This research will develop an innovative driver drowsiness detecting technology. With drowsiness attributable to substantial road fatalities, this technology aims to reduce this emotional and socio-economic burden on the community, contributing to national and community benefit by providing a safer road environment.Read moreRead less
Reproductive technologies for the conservation of a critically endangered marsupial, the Gilberts potoroo. The Gilberts potoroo is currently Australia's most endangered mammal (population total is less than 40). Natural breeding in captivity has not been successful so reproductive technology, especially artificial insemination, will be developed contribute to the survival of the species. This will involve detailed testing of techniques for semen collection and preservation, oestrus detection an ....Reproductive technologies for the conservation of a critically endangered marsupial, the Gilberts potoroo. The Gilberts potoroo is currently Australia's most endangered mammal (population total is less than 40). Natural breeding in captivity has not been successful so reproductive technology, especially artificial insemination, will be developed contribute to the survival of the species. This will involve detailed testing of techniques for semen collection and preservation, oestrus detection and artificial insemination, initially with the closely related Long-nosed potoroo. Once reliable protocols are developed, they will be applied to the Gilberts potoroo. If successful, this will be the first application of artificial insemination to increasing the numbers of a threatened species of marsupial in Australia.Read moreRead less
Early Nutrition and the Programming of Body Composition in Cattle. Australia is the worlds largest beef exporter with the net value of beef export valued at $4.6 billion. The economy of rural and regional Australia relies upon cattle production with the industry bringing a total value to these communities of $7.4 billion. Cattle production in remote Australia is becoming less viable as input costs of production increase relative to income earned and the beef industry is keen to transform produc ....Early Nutrition and the Programming of Body Composition in Cattle. Australia is the worlds largest beef exporter with the net value of beef export valued at $4.6 billion. The economy of rural and regional Australia relies upon cattle production with the industry bringing a total value to these communities of $7.4 billion. Cattle production in remote Australia is becoming less viable as input costs of production increase relative to income earned and the beef industry is keen to transform production methods. Protein is the major limiting nutrient in the Australian rangelands and this proposal will provide new information on how providing protein to cattle during critical periods in their pregnancy can 'program' the body composition of the growing calf to be optimal for the market.Read moreRead less
Re-balancing global resources: Manipulating toxic prussic acid (dhurrin) to improve nitrogen use efficiency in forage sorghum in a changing climate. Sorghum is grown widely is Australia and world-wide for forage, grain (mostly for animal feed) and biofuels. It grows well in dry areas. The problem is that the leaves contain a toxin that releases prussic acid (cyanide) that can reduce animal production or even kill stock feeding on it, especially when water stressed. The problem will get worse wit ....Re-balancing global resources: Manipulating toxic prussic acid (dhurrin) to improve nitrogen use efficiency in forage sorghum in a changing climate. Sorghum is grown widely is Australia and world-wide for forage, grain (mostly for animal feed) and biofuels. It grows well in dry areas. The problem is that the leaves contain a toxin that releases prussic acid (cyanide) that can reduce animal production or even kill stock feeding on it, especially when water stressed. The problem will get worse with climate change. Low-cyanide plants developed by us using non-GM methods grow fast, but accumulate nitrate instead which is also toxic. This is a waste of expensive fertiliser too. We aim to develop plants that divert resources to growth instead of toxins in order to reduce fertiliser use and help prepare for the future. The fast growing plants may also be useful as a biofuel crop.Read moreRead less
Unravelling the links between plant transpiration, soil water and nitrate movement: impact of high atmospheric CO2 and irrigation strategy. Australia's serious environmental problems, soil salinity and acidity, may be greatly affected by rising atmospheric CO2 and irrigation strategies. This will occur if the movement of soil water and nitrate changes with transpiration. We will generate different transpiration rates by varying atmospheric CO2 above pastures and irrigation strategies in vineya ....Unravelling the links between plant transpiration, soil water and nitrate movement: impact of high atmospheric CO2 and irrigation strategy. Australia's serious environmental problems, soil salinity and acidity, may be greatly affected by rising atmospheric CO2 and irrigation strategies. This will occur if the movement of soil water and nitrate changes with transpiration. We will generate different transpiration rates by varying atmospheric CO2 above pastures and irrigation strategies in vineyards. The commercial partner's newly developed soil sensors allow, for the first time, simultaneous 3-D measurement of soil water and nitrate in real-time. The results will answer long-standing questions about impacts of transpiration rates on plant nitrogen uptake and generate valuable new knowledge for sustainable management of pastures and horticultural crops. Read moreRead less
Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four ne ....Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.Read moreRead less
Nutritional and bacterial influences on gut and peripheral homeostasis. Nutritional and bacterial influences on gut and peripheral homeostasis. This project aims to understand the role of macronutrients on gut homeostasis. While the understanding of what factors affect gut homeostasis is still in its infancy, scientists know that its disruption contributes to a broad range of inflammatory diseases, including type 1 diabetes and asthma. This project will determine the role of specific macronutrie ....Nutritional and bacterial influences on gut and peripheral homeostasis. Nutritional and bacterial influences on gut and peripheral homeostasis. This project aims to understand the role of macronutrients on gut homeostasis. While the understanding of what factors affect gut homeostasis is still in its infancy, scientists know that its disruption contributes to a broad range of inflammatory diseases, including type 1 diabetes and asthma. This project will determine the role of specific macronutrients on gut microbiota, gut epithelium, and immunity in mice, and the receptors involved. This research could ultimately lead to significant decreases in the cost of healthcare.Read moreRead less
Predicting the Impact of Damming on the Endangered Mary River Turtle. Little is known about the effects of inland river alteration on the ecology of freshwater turtles, where river damming results in dramatic changes in river physical, chemical and biological characteristics. In Australia there are 446 large dams, necessary for hydro-electric power, navigation, flood control, irrigation and drinking water. Many of these rivers are inhabited by freshwater turtles, endemic to Australia, and this ....Predicting the Impact of Damming on the Endangered Mary River Turtle. Little is known about the effects of inland river alteration on the ecology of freshwater turtles, where river damming results in dramatic changes in river physical, chemical and biological characteristics. In Australia there are 446 large dams, necessary for hydro-electric power, navigation, flood control, irrigation and drinking water. Many of these rivers are inhabited by freshwater turtles, endemic to Australia, and this project will assess the impact of changes in habitat quality on the endangered Mary River Turtle (Elusor macrurus). The study comes at a timely opportunity, as proposed river damming will substantially alter the turtles' habitat, and its survival potential remains unknown.Read moreRead less
Understanding salt and water dynamics to enhance the quality of turfgrasses irrigated with saline water in a Mediterranean environment: an evaluation of four species. This project will elucidate quantitative relationships between growth and the levels of root-zone salts and water. The results will enable development of best practices for use of salt-tolerant turfgrass species, to (i) improve aesthetics of many rural and coastal towns faced with salinity, and (ii) enable use of saline groundwater ....Understanding salt and water dynamics to enhance the quality of turfgrasses irrigated with saline water in a Mediterranean environment: an evaluation of four species. This project will elucidate quantitative relationships between growth and the levels of root-zone salts and water. The results will enable development of best practices for use of salt-tolerant turfgrass species, to (i) improve aesthetics of many rural and coastal towns faced with salinity, and (ii) enable use of saline groundwater, and thus conserve precious potable water, reducing costs of water for irrigation. The project is also of relevance to saline agricultural areas, as the species investigated could also have applications in saltland pastures. The outcomes will contribute to National priorities dealing with salinity management and protection of water resources. Read moreRead less