Global Gravitational Wave Astronomy. To listen to the universe with gravitational waves needs a global array of gravitational wave observatories, and one of these must be in the southern hemisphere - in Australia. By definitively answering outstanding questions about an Australian gravitational wave observatory - Where should it be? How sensitive? What astronomy will it aid? - we make the case for the international community to help build this observatory, investing hundreds of millions of dolla ....Global Gravitational Wave Astronomy. To listen to the universe with gravitational waves needs a global array of gravitational wave observatories, and one of these must be in the southern hemisphere - in Australia. By definitively answering outstanding questions about an Australian gravitational wave observatory - Where should it be? How sensitive? What astronomy will it aid? - we make the case for the international community to help build this observatory, investing hundreds of millions of dollars in rural Australia and keeping Australia on the cutting edge of all branches of astronomy. As a flagship client of advanced data GRID technologies, we will also shape the growth of Australian knowledge of, and infrastructure for, next-generation communications technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883030
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
High-Resolution Field Emission Scanning Electron Microscopy (FESEM) Platform for Characterisation at the Nanometre-Level. The Field Emission Scanning Electron Microscope (FESEM) is designed to provide fundamental insights into physical and biological systems though characterisation and analysis of structures on nanometre length scales. This versatile instrument will support a wide range of research projects covering all four national research priorities. These range from the characterisation of ....High-Resolution Field Emission Scanning Electron Microscopy (FESEM) Platform for Characterisation at the Nanometre-Level. The Field Emission Scanning Electron Microscope (FESEM) is designed to provide fundamental insights into physical and biological systems though characterisation and analysis of structures on nanometre length scales. This versatile instrument will support a wide range of research projects covering all four national research priorities. These range from the characterisation of light alloys to boost and intensify Australia's aluminium, magnesium and titanium alloy industries, to tissue engineering for the repair of human elastic tissues in skin, artery, bladder and lung, to the study of microtubules in plant cells for genetic manipulation of plants to withstand environmental stresses such as drought or salinity.Read moreRead less
Industrial-strength X-ray Phase Tomography. The unique 3D imaging capability provided as a result of this project will have application to advanced manufacturing as a non-destructive evaluation for materials and micro-components. For instance, the internal structure of aerogels, porous light metals, polymers and carbon fibre based materials can all be imaged at the microscale. Similar benefits flow in health sciences where organic processes can be observed in place and where, for instance, small ....Industrial-strength X-ray Phase Tomography. The unique 3D imaging capability provided as a result of this project will have application to advanced manufacturing as a non-destructive evaluation for materials and micro-components. For instance, the internal structure of aerogels, porous light metals, polymers and carbon fibre based materials can all be imaged at the microscale. Similar benefits flow in health sciences where organic processes can be observed in place and where, for instance, small animals used in research and clinical testing can be inspected internally without having to destroy them, thus allowing for repeated measurements.Read moreRead less
Quantitative Brain Dynamics. This proposal will benefit Australia through unique and fundamental contributions to understanding brain dynamics via the development of innovative approaches and technologies. It will contribute to the national priority goals of Breakthrough Science, Frontier Technologies, and Promoting an Innovation Culture and Economy. Science outcomes will include improved understanding and probing of brain self-organization, dynamics, and function, including unique contributio ....Quantitative Brain Dynamics. This proposal will benefit Australia through unique and fundamental contributions to understanding brain dynamics via the development of innovative approaches and technologies. It will contribute to the national priority goals of Breakthrough Science, Frontier Technologies, and Promoting an Innovation Culture and Economy. Science outcomes will include improved understanding and probing of brain self-organization, dynamics, and function, including unique contributions to understanding alertness and the foundations of vision. These outcomes will be applied to develop new technologies for brain imaging and monitoring.Read moreRead less
Characterisation of two-pore domain potassium channels: structure-function studies of the M1-P1 loops of TASK channels. TWIK-related Acid Sensitive K+ (TASK) channels are members of the novel class of two-pore domain potassium channel family. They are potently inhibited by local anaesthetics and have been implicated as having important roles in many pathophysiological conditions such as heart arrythmias, stroke, epilepsy, breast and other cancers. The in depth structural and functional character ....Characterisation of two-pore domain potassium channels: structure-function studies of the M1-P1 loops of TASK channels. TWIK-related Acid Sensitive K+ (TASK) channels are members of the novel class of two-pore domain potassium channel family. They are potently inhibited by local anaesthetics and have been implicated as having important roles in many pathophysiological conditions such as heart arrythmias, stroke, epilepsy, breast and other cancers. The in depth structural and functional characterisation of this class of potassium channels is of great importance as they are interesting targets for new therapeutic developments. Advancement of knowledge in the structure and function of these channels will underpin drug targeting that will aid preventative healthcare, allowing Australians to age well and age productively.Read moreRead less
WAVES IN THE MIDDLE ATMOSPHERE. Atmospheric waves have a profound influence in the atmosphere. A unique network of radars in the southern hemisphere will be used to study wave processes in the upper atmosphere. The project will investigate causes of wave variability, wave sources and wave-wave interactions and will involve satellite measurements and international collaboration. Results will guide the development and testing of schemes that incorporate the effects of small-scale waves in numerica ....WAVES IN THE MIDDLE ATMOSPHERE. Atmospheric waves have a profound influence in the atmosphere. A unique network of radars in the southern hemisphere will be used to study wave processes in the upper atmosphere. The project will investigate causes of wave variability, wave sources and wave-wave interactions and will involve satellite measurements and international collaboration. Results will guide the development and testing of schemes that incorporate the effects of small-scale waves in numerical weather and climate models. Outcomes from the project will have application in modelling climate change.Read moreRead less
Zirconium alloying and grain refinement of magnesium alloys with ZirCAST. Zirconium alloying and grain refinement is a key issue restricting the commercial production of value-added zirconium-containing magnesium alloys for use in the automotive industry. This 3-year linkage program builds on the applicants' invention of a proprietary grain refiner ZirCAST, and is undertaken to investigate the major fundamental aspects of zirconium alloying and grain refinement with ZirCAST. In addition to an ex ....Zirconium alloying and grain refinement of magnesium alloys with ZirCAST. Zirconium alloying and grain refinement is a key issue restricting the commercial production of value-added zirconium-containing magnesium alloys for use in the automotive industry. This 3-year linkage program builds on the applicants' invention of a proprietary grain refiner ZirCAST, and is undertaken to investigate the major fundamental aspects of zirconium alloying and grain refinement with ZirCAST. In addition to an excellent postgraduate training environment, it aims to provide and develop, in partnership with industry, optimum zirconium alloying and grain refinement technology with ZirCAST and enhance Australia's leading global position in this strategically and commercially important area.Read moreRead less
Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which in ....Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which includes devices for the European Space Agency's Atomic Clock Ensemble in Space mission, which is due for launch in 2010. This project highlights the importance of Australian Science in a high profile international mission.Read moreRead less
Electro-active and migratory peptides in lipid bilayers: NMR and biophysical studies. All living things are characterized by the separation of inner space from the surrounding medium by a self-assembling membrane. Selective entry and exit of water, ions and solutes is a defining feature of each type of cell. Some proteins sense the voltage difference across the cell membrane and open or close in response to voltage changes. Others, like bacterial toxins assemble in the membrane as pores, while o ....Electro-active and migratory peptides in lipid bilayers: NMR and biophysical studies. All living things are characterized by the separation of inner space from the surrounding medium by a self-assembling membrane. Selective entry and exit of water, ions and solutes is a defining feature of each type of cell. Some proteins sense the voltage difference across the cell membrane and open or close in response to voltage changes. Others, like bacterial toxins assemble in the membrane as pores, while other peptides migrate across the membrane piggy-backing their peptide cargo. The aim is to understand the molecular mechanisms in examples of these membrane-active peptides and proteins with a view to enabling rational intervention into their operation in situ in normal and disease states.Read moreRead less
NMR studies of membrane proteins and peptides in novel amphiphilic mesophases. Membrane proteins are the next frontier in structural biology. Our goal is the structural and mechanistic characterization of the proteins and peptides from platypus venom and a cardiac potassium ion channel, HERG, that has a particular role in the suppression of cardiac arrhythmias. To do this we will refine and develop methods using amphiphilic mesophases and micelles and state-of-the-art NMR spectroscopy. Electrop ....NMR studies of membrane proteins and peptides in novel amphiphilic mesophases. Membrane proteins are the next frontier in structural biology. Our goal is the structural and mechanistic characterization of the proteins and peptides from platypus venom and a cardiac potassium ion channel, HERG, that has a particular role in the suppression of cardiac arrhythmias. To do this we will refine and develop methods using amphiphilic mesophases and micelles and state-of-the-art NMR spectroscopy. Electrophysiological analysis of ion channels and interactions with toxins will relate NMR structures to function. The NMR methodologies we develop will have broad applicability to membrane proteins in general.
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