Discovery Early Career Researcher Award - Grant ID: DE160100630
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Relating function of complex networks to structure using information theory. This project aims to investigate networks in order to translate network function to a universal language of information flows. Network science has used common tools to reveal universal connection structures within various biological and man-made networks – our brains, social networks and power grids are all networks of interacting components. Yet there is no common method to study the function of these networks and how ....Relating function of complex networks to structure using information theory. This project aims to investigate networks in order to translate network function to a universal language of information flows. Network science has used common tools to reveal universal connection structures within various biological and man-made networks – our brains, social networks and power grids are all networks of interacting components. Yet there is no common method to study the function of these networks and how such function is coupled with structure. This project aims to relate network structure to function by using measures of information processing as a generally-applicable framework. This will deliver a theory of how structure gives rise to dynamics and how structure can be optimised for desired dynamics.Read moreRead less
Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanis ....Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanisms underlying arrhythmias which contribute to ?sudden cardiac death? in young men, and suggesting strategies for artificial pacemakers to effectively arrest abnormal rhythms before they convert to potentially fatal fibrillation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100807
Funder
Australian Research Council
Funding Amount
$321,536.00
Summary
Anion transporters as novel therapeutic agents. This project plans to use simulations and modelling for the rational design of anion transporters as therapeutic agents. Malfunctioning of certain anion transport mechanisms can lead to serious diseases, most notably cystic fibrosis. Anion transporters are molecules that mediate the lipid bilayer transport of negatively charged ions, and are therefore promising drug candidates for the treatment of these diseases. Many of these compounds also displa ....Anion transporters as novel therapeutic agents. This project plans to use simulations and modelling for the rational design of anion transporters as therapeutic agents. Malfunctioning of certain anion transport mechanisms can lead to serious diseases, most notably cystic fibrosis. Anion transporters are molecules that mediate the lipid bilayer transport of negatively charged ions, and are therefore promising drug candidates for the treatment of these diseases. Many of these compounds also display anti-tumour properties. The intended outcome of this project is the development of new tools to accelerate the discovery of novel anion transporters, understand their structure activity relationship, and design more effective therapeutic agents.Read moreRead less
Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
Advanced Monte Carlo Methods for Spatial Processes. The modeling and analysis of spatial data relies more and more on sophisticated Monte Carlo simulation methods. However, with the growing complexity of today's spatial data, traditional Monte Carlo methods increasingly face difficulties in terms of speed and accuracy. The aim of this project is to develop new theory and applications at the interface of Monte Carlo methods and spatial statistics, building upon exciting theoretical and computatio ....Advanced Monte Carlo Methods for Spatial Processes. The modeling and analysis of spatial data relies more and more on sophisticated Monte Carlo simulation methods. However, with the growing complexity of today's spatial data, traditional Monte Carlo methods increasingly face difficulties in terms of speed and accuracy. The aim of this project is to develop new theory and applications at the interface of Monte Carlo methods and spatial statistics, building upon exciting theoretical and computational advances in both areas in recent years. The research will stimulate the design of microscopic and macroscopic complex spatial structures with superior properties, such as composite materials, solar cells, telecommunication networks, mining operations, and road systems.Read moreRead less
Special Research Initiatives - Grant ID: SR0354604
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Network in Imaging Science and Technology. The ARC Network in Imaging Science and Technology is a field of research network covering the fundamental science and technological development of applied imaging systems. The network will encompass all aspects of the imaging sciences from image formation, through image processing and analysis, and on to image visualisation. In particular, the network will focus on a number of application areas that utilise these core technologies: medical imaging; ....ARC Network in Imaging Science and Technology. The ARC Network in Imaging Science and Technology is a field of research network covering the fundamental science and technological development of applied imaging systems. The network will encompass all aspects of the imaging sciences from image formation, through image processing and analysis, and on to image visualisation. In particular, the network will focus on a number of application areas that utilise these core technologies: medical imaging; surveillance and security; materials science and metallurgy; environmental monitoring; and consumer imaging. In this way, the network will provide an environment for creative inter-disciplinary research to the socio-economic benefit of Australia.Read moreRead less
Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR sy ....Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR system to be used to correct the simultaneously acquired PET data for patient motion. This research is an excellent opportunity for Australian researchers to make important contributions to an emerging technology with high economic potential, and will strengthen Australia's international position in engineering and biomedical systems development.Read moreRead less
Special Research Initiatives - Grant ID: SR0567109
Funder
Australian Research Council
Funding Amount
$69,438.00
Summary
Smart astronomy: using computational science to understand distant radio galaxies. Radio galaxies are among the largest galaxies in the universe with their copious radio emission powered by massive black holes. Australian radio telescopes are very effective at tracing these massive galaxies back in time so we can measure how black holes formed and developed. These measurements depend on reliable identification of the radio sources with our optical telescopes to make vital measurements of their d ....Smart astronomy: using computational science to understand distant radio galaxies. Radio galaxies are among the largest galaxies in the universe with their copious radio emission powered by massive black holes. Australian radio telescopes are very effective at tracing these massive galaxies back in time so we can measure how black holes formed and developed. These measurements depend on reliable identification of the radio sources with our optical telescopes to make vital measurements of their distances. Until now this identification process has been straightforward, but the next generation of studies will look so far back in time that the identification will become ambiguous. Our project will develop a software tool that applies techniques from computational science to overcome the ambiguity in this matching problem.Read moreRead less
Foundations and advanced algorithms for topological image processing. Building on new links between the mathematical discipline of homology and digital images, this project develops a new class of topology-driven image analysis techniques that will improve the accuracy and reliability of predictions made from the powerful new generation of three dimensional microscopes.
Discovery Early Career Researcher Award - Grant ID: DE180101268
Funder
Australian Research Council
Funding Amount
$367,446.00
Summary
Inference and resilient control of complex cyber-physical networks. This project aims to establish a fundamental framework to efficiently analyse and control critical, modern infrastructure networks such as power grids and the Internet. The project expects to bridge the gap between cyber-physical network theory and network resilience engineering through developing a body of knowledge about cyber-physical systems, security analysis and emergence of network behaviours. The project will develop des ....Inference and resilient control of complex cyber-physical networks. This project aims to establish a fundamental framework to efficiently analyse and control critical, modern infrastructure networks such as power grids and the Internet. The project expects to bridge the gap between cyber-physical network theory and network resilience engineering through developing a body of knowledge about cyber-physical systems, security analysis and emergence of network behaviours. The project will develop design methodologies to improve the resilience of these networks against internal faults and external attacks. This should improve the robustness and invulnerability of Australian power grids and the Internet against random failures and malicious cyber-physical attacks.Read moreRead less