Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being bu ....Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being built to leading international workers. The National Research Priority Goals of Frontier Technologies, Breakthrough Science, Smart Information Use, and Promoting an Innovation Economy will thus be advanced.Read moreRead less
Robust and Distributed Control of Quantum Systems. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust and distributed feedback controllers for quantum systems. The project will also add to Australia's strength in quantum ....Robust and Distributed Control of Quantum Systems. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust and distributed feedback controllers for quantum systems. The project will also add to Australia's strength in quantum technology by contributing to the research training of young researchers with expertise both in control systems engineering and quantum technology. This project will help Australia reap the maximum possible benefit from the new industries to emerge from the field of quantum technology.Read moreRead less
Robust Feedback Control in Quantum Technology. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust feedback controllers for quantum systems. The project will also add to Australia's strength in quantum technology by contr ....Robust Feedback Control in Quantum Technology. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust feedback controllers for quantum systems. The project will also add to Australia's strength in quantum technology by contributing to the research training of young researchers with expertise both in control systems engineering and quantum technology. This project will help Australia reap the maximum possible benefit from the new industries to emerge from the field of quantum technology.
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New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the fou ....New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the foundations of systematic theories of robust, coherent and nonlinear quantum feedback control and lead to advances in the control of highly resonant systems which underlie experimental quantum and nano technology. This will enable Australia to reap great benefits as this new technological area emerges.Read moreRead less
Sinusoidal voltage protocols for characterisation of ion channel kinetics. This project aims to implement an innovative approach to modelling ion channel behaviour that employs short, information-rich datasets and parameter inference. Using the hERG potassium channel as a test case, the project will show that this approach is more efficient than current methods and outperforms all published models in independent validations. The project aims to extend on initial implementation to probe the therm ....Sinusoidal voltage protocols for characterisation of ion channel kinetics. This project aims to implement an innovative approach to modelling ion channel behaviour that employs short, information-rich datasets and parameter inference. Using the hERG potassium channel as a test case, the project will show that this approach is more efficient than current methods and outperforms all published models in independent validations. The project aims to extend on initial implementation to probe the thermodynamics and pharmacology of ion channel gating. The anticipated outcomes are to grow fundamental knowledge of ion channel biophysics and ability to probe ion channel function in silico. The project will build on an emerging collaboration between international leaders in physiology, pharmacology, mathematics and computer modelling. The methodology and fundamental knowledge generated will significantly advance our understanding of the physiology and biophysics of ion channels, while the application of the method will have direct impact in the pharmaceutical industry and regulatory science.Read moreRead less
Mathematical model reduction for complex networks. This project aims to develop new mathematical methodology to describe the collective behaviour of large networks of oscillators with parameters called collective coordinates. This will allow for the quantitative description of finite-size networks as well as chaotic dynamics, which are both out of reach for current model reduction methods. The project will apply methodology to understand the causes of, and ways to prevent, glitches and failure i ....Mathematical model reduction for complex networks. This project aims to develop new mathematical methodology to describe the collective behaviour of large networks of oscillators with parameters called collective coordinates. This will allow for the quantitative description of finite-size networks as well as chaotic dynamics, which are both out of reach for current model reduction methods. The project will apply methodology to understand the causes of, and ways to prevent, glitches and failure in the emerging modern decentralised power grids. This will develop a framework to address this question, tailored to deal with the hitherto uncharted case of finite-size networks.Read moreRead less
Special Research Initiatives - Grant ID: SR0354553
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Network on Control, Dynamics and Systems (NCDS). Control systems theory provides principles and methods for design of complex engineering systems that automatically maintain desired performance despite changes in their environment (e.g. autopilot in an aircraft). This field is facing many new exciting challenges at the dawn of new millenium, such as design of complex engineering systems in possibly networked, asynchronous and distributed environments. The network will play a major role in addres ....Network on Control, Dynamics and Systems (NCDS). Control systems theory provides principles and methods for design of complex engineering systems that automatically maintain desired performance despite changes in their environment (e.g. autopilot in an aircraft). This field is facing many new exciting challenges at the dawn of new millenium, such as design of complex engineering systems in possibly networked, asynchronous and distributed environments. The network will play a major role in addressing these challenges by providing a national research focus, facilitating collaboration and the sharing of people and ideas. By delivering a National Graduate School, the network will enhance learning conditions for graduate students. Moreover, it will provide an important catalyst between Australian universities and industry. This initiative will be essential in assessing the present state of control research in Australia and drafting a detailed plan for the network's leading research role in the future. Read moreRead less
Neural spike variability: unifying conflicting views of neural dynamics. The project aims to improve our understanding of neural dynamics. The brain represents and processes information by means of neural voltage spikes, which show great variability in their timing. Understanding the origin of such variable neural dynamics is a long-standing problem in neuroscience. The aim of this project is to develop a novel account of variable neural dynamics, unravelling their computational principles in th ....Neural spike variability: unifying conflicting views of neural dynamics. The project aims to improve our understanding of neural dynamics. The brain represents and processes information by means of neural voltage spikes, which show great variability in their timing. Understanding the origin of such variable neural dynamics is a long-standing problem in neuroscience. The aim of this project is to develop a novel account of variable neural dynamics, unravelling their computational principles in the brain, and unifying current leading but conflicting theories. The model developed in this project would be used to explain a range of empirical observations, and the principles unravelled would be applied to understand spike-timing based neural coding. The new knowledge gained in this project may have profound implications for designing brain-like computing devices.Read moreRead less
New mathematics to improve understanding of anomalously diffusing reactions. Standard mathematical models for particles that diffuse and react are based on assumptions that improving technologies have revealed do not always hold. This project aims to create a mathematical framework that generalises existing approaches, taking into account observations of complicated transport behaviour at many scales, and including the impact of this anomalous transport on reactions. The development of the fram ....New mathematics to improve understanding of anomalously diffusing reactions. Standard mathematical models for particles that diffuse and react are based on assumptions that improving technologies have revealed do not always hold. This project aims to create a mathematical framework that generalises existing approaches, taking into account observations of complicated transport behaviour at many scales, and including the impact of this anomalous transport on reactions. The development of the framework will involve innovative approaches utilising mathematical techniques, including dynamical systems, fractional calculus, and stochastic processes. This project aims to deliver new mathematical models that can be adopted in applications across different discipline areas, and especially in biological systems. Read moreRead less
Advanced mathematical modelling and computation of fractional sub-diffusion problems in complex domains. Over the past few decades, researchers have observed numerous biological, physical and financial systems in which some key underlying random motion fails to conform to the classical model of diffusion. The project will extend current macroscopic models describing such anomalous sub-diffusion by correctly incorporating the confounding effects of nonlinear reactions, forcing and irregular geome ....Advanced mathematical modelling and computation of fractional sub-diffusion problems in complex domains. Over the past few decades, researchers have observed numerous biological, physical and financial systems in which some key underlying random motion fails to conform to the classical model of diffusion. The project will extend current macroscopic models describing such anomalous sub-diffusion by correctly incorporating the confounding effects of nonlinear reactions, forcing and irregular geometry. A key aspect of the project is the design of new algorithms that will fundamentally improve the accuracy and efficiency of direct numerical simulations of sub-diffusion in challenging applications. Read moreRead less