Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which in ....Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which includes devices for the European Space Agency's Atomic Clock Ensemble in Space mission, which is due for launch in 2010. This project highlights the importance of Australian Science in a high profile international mission.Read moreRead less
Microwave Frequency Standards: Testing Fundamental Physics and Developing New Devices. Highly frequency stable oscillators may be used as frequency or timing standards (clocks) and have commercial application as well as application of testing fundamental physical principles. This project is to continue the development of novel frequency standards in collaboration with some of the best research institutes in France funded by the French Space Agency (CNES). With the advent of the International Spa ....Microwave Frequency Standards: Testing Fundamental Physics and Developing New Devices. Highly frequency stable oscillators may be used as frequency or timing standards (clocks) and have commercial application as well as application of testing fundamental physical principles. This project is to continue the development of novel frequency standards in collaboration with some of the best research institutes in France funded by the French Space Agency (CNES). With the advent of the International Space Station and new atomic clocks, the physics community is embarking on an experimental program that will make use of the microgravity environment of space. Combined with the new improved timing it will be possible to perform new experimental tests of general and special relativity, tests for drifts in the fine structure constant and tests for a preferred direction of the speed of light at unprecedented sensitivity.Read moreRead less
Increasing the Efficiency of Biomolecular Simulations. This program will extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation t ....Increasing the Efficiency of Biomolecular Simulations. This program will extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation techniques in biomolecular systems, which are widely used within the chemical and pharmaceutical industries. It will also provide opportunities for the training and development of young Australian researchers with top European laboratories. Read moreRead less
The role of water uptake in novel all solid-state polymeric ion sensors. This research will enable the development of robust all solid-state polymeric ion sensors based on unplasticized copolymers. Significantly, the physical and chemical robustness of these copolymer ion sensors will allow their widespread use in new and exciting analytical applications, e.g., in-situ analysis of environmental samples in submersible instruments, clinical analysis of whole blood, in-vivo use of miniaturized ele ....The role of water uptake in novel all solid-state polymeric ion sensors. This research will enable the development of robust all solid-state polymeric ion sensors based on unplasticized copolymers. Significantly, the physical and chemical robustness of these copolymer ion sensors will allow their widespread use in new and exciting analytical applications, e.g., in-situ analysis of environmental samples in submersible instruments, clinical analysis of whole blood, in-vivo use of miniaturized electrodes in biological media, especially single cells and minute samples in biology and forensic science, etc. Extensive use of neutron characterization techniques aligns strongly this project with the new OPAL reactor to be commissioned in 2007.Read moreRead less
Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provi ....Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provide direct advantages to society, including minimally invasive and fast in-vivo diagnostics, localised delivery of drugs and therapeutic agents with increased bioavailability, patient acceptability and reduced healthcare costs.Read moreRead less
Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Austral ....Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Australian scientists with their first access to x-ray microscopy at its optimum wavelength; and secondly it will provide a superb testbed for x-ray microscopy to be enhanced using unique methods being developed in Australia.Read moreRead less
Blocking of the interfaces of polymeric ion sensors - implications for novel sensor applications. Control of the transmembrane fluxes of polymeric ion sensors represents a paradigm shift that has revolutionised the use of these analytically important devices. This project will develop and characterise innovative methods for controlling these fluxes by using blocked interfaces, and this has important ramifications for the development of robust and reliable sensors, as well as novel biosensors.
A rational approach to a high-resolution structure of the multidrug transporter EmrE. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. Multidrug transporters are membrane proteins responsible for antibiotic resistance in humans. A high-resolution structure of a multidrug resistance protein, together with comprehensive biochemical characterization, w ....A rational approach to a high-resolution structure of the multidrug transporter EmrE. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. Multidrug transporters are membrane proteins responsible for antibiotic resistance in humans. A high-resolution structure of a multidrug resistance protein, together with comprehensive biochemical characterization, would enable a detailed understanding of how these protein functions. Potentially it could also aid in the development of specific inhibitors that would prevent EmrE (and perhaps other similar proteins) from carry out its harmful mission. Read moreRead less
Collaboration with The NANTEN2 International Star Formation Consortium. Through this collaboration Australia, for a very modest sum, will gain its first direct access to the astronomical facilities of the Atacama plateau, one of the best sites for investigating star formation on the Earth. The project fosters international collaboration, and raises the profile of Australian science and facilities by bringing together astronomers from Australia, Japan, Germany, Korea, Chile and Switzerland.The co ....Collaboration with The NANTEN2 International Star Formation Consortium. Through this collaboration Australia, for a very modest sum, will gain its first direct access to the astronomical facilities of the Atacama plateau, one of the best sites for investigating star formation on the Earth. The project fosters international collaboration, and raises the profile of Australian science and facilities by bringing together astronomers from Australia, Japan, Germany, Korea, Chile and Switzerland.The collaborations formed during this project will enable Australian scientists future access to new front-line telescopes such as the Atacama Large Millimeter Array (ALMA), due to commence operations in 2010. Read moreRead less
Near-field Cosmology with Globular Clusters. Globular star clusters are the astronomical equivalent of fossils, and as such they provide unique insight into the early epochs of the Universe. This project will establish a link between two world-leading research groups in this area. This Australian-Canadian collaboration will train the next generation of PhD students, create innovative 3D visualisation applications and produce a book on globular clusters.