The mechanochemical basis of cell polarity. This project aims to study how epithelial cells initiate polarisation, a major question in biology that conventional biochemical, cell biological and genetic approaches have not answered. This project will investigate the mechanochemical basis of symmetry breaking in the cellular cortex, a thin layer of actomyosin filaments underneath the plasma membrane, and how this forms signalling zones. Understanding polarity is expected to improve epithelia manip ....The mechanochemical basis of cell polarity. This project aims to study how epithelial cells initiate polarisation, a major question in biology that conventional biochemical, cell biological and genetic approaches have not answered. This project will investigate the mechanochemical basis of symmetry breaking in the cellular cortex, a thin layer of actomyosin filaments underneath the plasma membrane, and how this forms signalling zones. Understanding polarity is expected to improve epithelia manipulation in disciplines from tissue engineering to regenerative biology and reveal how epithelial architecture and physiology are generated.Read moreRead less
Watching planets grow in real time. This project will conduct the first in-depth examination of the atmospheres of newly born small planets around other stars, yielding a better understanding of how planets evolve early in their lives. The atmosphere of our Earth is its most distinguishing feature. Key outcomes of this project include unveiling the mechanisms that drive the erosion of early planetary atmospheres, leading to a better understanding of the processes that sculpt all planets, includi ....Watching planets grow in real time. This project will conduct the first in-depth examination of the atmospheres of newly born small planets around other stars, yielding a better understanding of how planets evolve early in their lives. The atmosphere of our Earth is its most distinguishing feature. Key outcomes of this project include unveiling the mechanisms that drive the erosion of early planetary atmospheres, leading to a better understanding of the processes that sculpt all planets, including those in our own Solar System. The project leverages Australian and international expertise across exoplanetary, stellar, and Solar System astrophysics, with key outcomes in developing techniques for Australian utilisation of world-class multi-wavelength space facilities. Read moreRead less
Plasmonic nanoparticle catalysis for nitrogen-based synthesis. Light can generate an optical force to capture small objects. This requires intense light – a laser, which limits optical trapping in catalysis applications. This project aims to apply plasmonic nanoparticles with normal-intensity light to take advantage of plasmonic-generated optical forces for catalytic chemical synthesis. The optical trapping/releasing of small molecules is highly selective and responsive to molecule structure and ....Plasmonic nanoparticle catalysis for nitrogen-based synthesis. Light can generate an optical force to capture small objects. This requires intense light – a laser, which limits optical trapping in catalysis applications. This project aims to apply plasmonic nanoparticles with normal-intensity light to take advantage of plasmonic-generated optical forces for catalytic chemical synthesis. The optical trapping/releasing of small molecules is highly selective and responsive to molecule structure and so presents a great opportunity to radically alter chemical synthesis pathways, which will be illustrated with reactions on liquid-solid and gas-solid interfaces. This highly innovative strategy will be used to discover new nitrogen-based syntheses which are both fundamentally and industrially important.Read moreRead less
Direct simulation of composite microstructures in fluid and elastic media. The proposed innovative computational methodology will improve the design and performance of a wide range of mechanisms and industrial processes involving particulate inclusions, from engineering to biological applications. The resultant technology will make a contribution to maintain and enhance Australia's role in the development of advanced engineering materials through manipulating their composite microstructures. The ....Direct simulation of composite microstructures in fluid and elastic media. The proposed innovative computational methodology will improve the design and performance of a wide range of mechanisms and industrial processes involving particulate inclusions, from engineering to biological applications. The resultant technology will make a contribution to maintain and enhance Australia's role in the development of advanced engineering materials through manipulating their composite microstructures. The proposed computational method will also lead to new opportunities for Australian companies that develop computer simulation software. Our researchers in computational mechanics will gain further opportunities to extend the advances this project will make.Read moreRead less
Bulk nanobubbles: from fundamentals to biomedical applications. This project aims to extend optical and acoustic tools to detect bulk nanobubbles, control their size-distributions, and understand how they interact with biomolecules. Liquids containing nanobubbles have numerous applications particularly in biomedicine. Using interdisciplinary approaches, this project expects to gain convincing evidence of the existence of bulk nanobubbles. This is expected to advance existing fundamental knowle ....Bulk nanobubbles: from fundamentals to biomedical applications. This project aims to extend optical and acoustic tools to detect bulk nanobubbles, control their size-distributions, and understand how they interact with biomolecules. Liquids containing nanobubbles have numerous applications particularly in biomedicine. Using interdisciplinary approaches, this project expects to gain convincing evidence of the existence of bulk nanobubbles. This is expected to advance existing fundamental knowledge at the forefront of soft matter research, and give Australia a decisive technological head start in a competitive and lucrative industry through patentable technology.Read moreRead less
In Search of New Gravity: testing advanced theories of gravity with cosmological data. The most startling discovery in cosmology in the last few decades has been that the Universe is accelerating. This remarkable fact indicates that our theory of gravity may need revision. Our current theory, Einstein’s theory of General Relativity, stands up in our solar system. If this theory breaks down on large scales, leading to the accelerating expansion, there must be some ‘cross-over’ scale where the the ....In Search of New Gravity: testing advanced theories of gravity with cosmological data. The most startling discovery in cosmology in the last few decades has been that the Universe is accelerating. This remarkable fact indicates that our theory of gravity may need revision. Our current theory, Einstein’s theory of General Relativity, stands up in our solar system. If this theory breaks down on large scales, leading to the accelerating expansion, there must be some ‘cross-over’ scale where the theory changes. This project will make theoretical predictions for those models that contain a cross-over and test them against current data for current and upcoming Australian cosmological surveys. It will determine if our current theory of gravity is a satisfactory theory, and if it is not, which new theory should replace it.Read moreRead less
Automated structural analysis of proteins by nuclear magnetic resonance (ASAP-NMR): a leap forward in structural studies of proteins using NMR spectroscopy. Proteins form the machinery that makes life possible, and this research will revolutionise study of their three-dimensional structure by making the process faster and cheaper. This approach will be applied to study proteins isolated from animal venoms in order to identify and develop novel pharmaceuticals and bio-insecticides.
The Births and Deaths of Stars. This project aims to investigate how the formation of planets and their stars are intertwined, by determining the ages, masses and compositions of the stars to unprecedented precision. It will probe the nature of compact remnants left behind when stars undergo supernova explosions by using an innovative approach to studying the motions of stars through space. Expected outcomes include the discovery of the closest supernova remnants to Earth, and detailed character ....The Births and Deaths of Stars. This project aims to investigate how the formation of planets and their stars are intertwined, by determining the ages, masses and compositions of the stars to unprecedented precision. It will probe the nature of compact remnants left behind when stars undergo supernova explosions by using an innovative approach to studying the motions of stars through space. Expected outcomes include the discovery of the closest supernova remnants to Earth, and detailed characterisations of the orbits of several hundred binary stars to reveal how stars form. This should provide significant benefits to major Australian astronomical surveys that are trying to understand Earth’s place within our Galaxy.Read moreRead less
High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use i ....High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use in diagnostics and drug development. It will provide vital information on the changes in cellular processes induced by malignant transformation, viral infection and aging. This work will generate both health and economic benefits for the community and have a positive impact on the international visibility of Australian biomedical research.Read moreRead less
Trapped Ion Imaging for Biomolecular Dynamics. The functionality of large biological molecules is driven by their chemical composition and the folded shape of their active form. The higher-order structure and dynamics of nucleic acids, proteins, carbohydrates, and lipids drives the chemistry of life. Combining single molecule microscopy and trapped ion mass spectroscopy will develop a new tool for precision measurements of higher-order folding dynamics in large biomolecules. Optical techniques i ....Trapped Ion Imaging for Biomolecular Dynamics. The functionality of large biological molecules is driven by their chemical composition and the folded shape of their active form. The higher-order structure and dynamics of nucleic acids, proteins, carbohydrates, and lipids drives the chemistry of life. Combining single molecule microscopy and trapped ion mass spectroscopy will develop a new tool for precision measurements of higher-order folding dynamics in large biomolecules. Optical techniques including Förster resonance energy transfer and super-resolution imaging can register changes in shape down to the nanometer scale. The uniquely adaptable ion trap environment enables manipulation of the surrounding solvent cage, temperature, and net charge down to the single quantum level. Read moreRead less