Characterisation and Development of Dynamic Supramolecular Combinatorial Libraries. The discovery of biologically active molecules, in particular drug discovery, requires the design and synthesis of host molecules that bind selectively to the biological target. Combinatorial chemistry has greatly assisted this discovery process as it allows the rapid screening of large collections of molecules. In this proposal, metal ion interactions will be used in the combinatorial library as this will grea ....Characterisation and Development of Dynamic Supramolecular Combinatorial Libraries. The discovery of biologically active molecules, in particular drug discovery, requires the design and synthesis of host molecules that bind selectively to the biological target. Combinatorial chemistry has greatly assisted this discovery process as it allows the rapid screening of large collections of molecules. In this proposal, metal ion interactions will be used in the combinatorial library as this will greatly increases the diversity of the pool of compounds to be screened for activity. Understanding how to generate and analyze these libraries has potential applications in drug screening, the discovery of new substrates, enzymes and inhibitors. Read moreRead less
Understanding the dynamics of the dark universe. This project aims to test theories of dark matter and dark energy with the ultimate goal of understanding the properties of the dark components of the universe and how those properties can be explained by new fundamental physics. The project will use two astronomical datasets, the Dark Energy Survey, with measurements of approximately 3000 supernovae, and the Dark Energy Spectroscopic Instrument, with measurements of 30 million galaxies. By compar ....Understanding the dynamics of the dark universe. This project aims to test theories of dark matter and dark energy with the ultimate goal of understanding the properties of the dark components of the universe and how those properties can be explained by new fundamental physics. The project will use two astronomical datasets, the Dark Energy Survey, with measurements of approximately 3000 supernovae, and the Dark Energy Spectroscopic Instrument, with measurements of 30 million galaxies. By comparing theoretical models to this combination of data the project will help to determine whether dark energy changes with time, measure detailed clustering properties of dark matter, and test advanced theories of gravity.Read moreRead less