In-situ Scanning Probe Microscopy of biological redox processes: nanoscale structure and morphology. The science behind this project underpins the development of nanobiotechnology. Immediate applications foreseen, are the development of biosensors and diagnostic devices based on our intimate knowledge of the nature of the protein attachment to a surface. Use of synthetic membranes to create biomimetic surfaces will impact significantly on our understanding of the role and contribution membranes ....In-situ Scanning Probe Microscopy of biological redox processes: nanoscale structure and morphology. The science behind this project underpins the development of nanobiotechnology. Immediate applications foreseen, are the development of biosensors and diagnostic devices based on our intimate knowledge of the nature of the protein attachment to a surface. Use of synthetic membranes to create biomimetic surfaces will impact significantly on our understanding of the role and contribution membranes have on protein structure, function hence disease.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775544
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
X-Ray Facility for 3-D High Resolution Diffraction Imaging of Nanostructures. Australian advances in quantitative x-ray imaging are at the leading edge of international efforts to permit 3D characterisation of the structure of materials and dynamic studies of structural changes. They have proven to be sensitive to local arrangement of materials at the nanometre scale, and they are emerging as critical tools in the development of advanced materials, which is a national research priority. This fac ....X-Ray Facility for 3-D High Resolution Diffraction Imaging of Nanostructures. Australian advances in quantitative x-ray imaging are at the leading edge of international efforts to permit 3D characterisation of the structure of materials and dynamic studies of structural changes. They have proven to be sensitive to local arrangement of materials at the nanometre scale, and they are emerging as critical tools in the development of advanced materials, which is a national research priority. This facility will allow the non-destructive 3D imaging of nanostructured materials to be performed as continual experimental development - something that is very difficult to achieve at synchrotron sources where access can be sporadic. The newly developed techniques will be applied to critical problems in emerging nanotechnologies.Read moreRead less
Static and Dynamic Forces in Colloidal and Fluid Systems. Novel research based around the Atomic Force Microscope are pursued to make ultra-sensitive measurement of forces between emulsion droplets and probe the mechanical properties of long molecules such as DNA. These studies generate basic knowledge that provides insight about emulsion stability that are of importance from the food and pharmaceutical industries to manufacturing drilling mud for oil wells. The results also provide qualitativ ....Static and Dynamic Forces in Colloidal and Fluid Systems. Novel research based around the Atomic Force Microscope are pursued to make ultra-sensitive measurement of forces between emulsion droplets and probe the mechanical properties of long molecules such as DNA. These studies generate basic knowledge that provides insight about emulsion stability that are of importance from the food and pharmaceutical industries to manufacturing drilling mud for oil wells. The results also provide qualitative and predictive information about the mechanisms that determine the interaction involving large bio-molecules such as DNA and proteins. The instrumentation created along the way has the potential to be developed into special purpose ultra-sensitive devices and sensors.Read moreRead less
Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Austral ....Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Australian scientists with their first access to x-ray microscopy at its optimum wavelength; and secondly it will provide a superb testbed for x-ray microscopy to be enhanced using unique methods being developed in Australia.Read moreRead less
Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its applicati ....Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its application in medical technology. Furthermore, the principle of temperature localisation due to thermal interference may provide new insights to account for the cause of conformational changes of proteins that result in diseases.Read moreRead less
Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop n ....Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop new techniques in single molecule manipulation, to perform studies not easily addressable using current techniques. The proposed research will form the basis of an enabling technology for Australian researchers to make breakthroughs in biomedical research, potentially leading to improvements in healthcare.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989915
Funder
Australian Research Council
Funding Amount
$127,000.00
Summary
X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new meth ....X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new methods will be used in the study of biological systems, leading to better drug design as well as in the study of materials, leading to stronger and lighter components. Read moreRead less
A Method to Characterise an Aberration-Corrected Electron Wave Field - a step towards quantitative electron microscopy. Australia has recently invested in a powerful, new electron microscope, one of the first in the world, which can image features at the atomic scale that could not be seen before. This project will forge a strategic partnership with the designer and the distributor of this microscope, to develop special new methods that will further increase the microscope's imaging power. This ....A Method to Characterise an Aberration-Corrected Electron Wave Field - a step towards quantitative electron microscopy. Australia has recently invested in a powerful, new electron microscope, one of the first in the world, which can image features at the atomic scale that could not be seen before. This project will forge a strategic partnership with the designer and the distributor of this microscope, to develop special new methods that will further increase the microscope's imaging power. This will give Australian scientists unique capabilities with which to investigate and engineer new materials for advanced technological applications and it will train young Australian scientists in these cutting-edge techniques.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989492
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Dynamic Texture Measurement Facility. A texture goniometer is an advanced tool for texture characterisation of steels, light alloys, nanomaterials, superconductors and minerals. The ability to conduct dynamic texture measurements will significantly enhance the effectiveness of four material-based research institutes at the University of Wollongong and at Deakin University, as well as collaborative research with BlueScope Steel. The research is directly aligned to the National Research Priority o ....Dynamic Texture Measurement Facility. A texture goniometer is an advanced tool for texture characterisation of steels, light alloys, nanomaterials, superconductors and minerals. The ability to conduct dynamic texture measurements will significantly enhance the effectiveness of four material-based research institutes at the University of Wollongong and at Deakin University, as well as collaborative research with BlueScope Steel. The research is directly aligned to the National Research Priority of Frontier Technologies for Building and Transforming Australian Industry. The equipment will provide a valuable resource for industries in the Illawarra region of NSW and in regional South-West Victoria.Read moreRead less
New experimental-analytical x-ray diffraction technique for unambiguous non-destructive characterization of high-performance silicon-germanium-carbon alloys for broadband communication devices. This research will develop a new x-ray diffraction technique for characterization of silicon-germanium-carbon semiconductor alloys. These are the basis for the new generation, ultra-high speed broadband telecommunication devices. The research will establish a new theoretical methodology for fundamental st ....New experimental-analytical x-ray diffraction technique for unambiguous non-destructive characterization of high-performance silicon-germanium-carbon alloys for broadband communication devices. This research will develop a new x-ray diffraction technique for characterization of silicon-germanium-carbon semiconductor alloys. These are the basis for the new generation, ultra-high speed broadband telecommunication devices. The research will establish a new theoretical methodology for fundamental studies of x-ray scattering phenomena in compound strain-compensated materials. The experiments will be carried out using the state-of-the-art laboratory and synchrotron radiation facilities in Australia, Japan and France. The project involves direct collaboration with IHP Germany, the world-leading semiconductor developer. Highly qualified postgraduate students will be extensively trained in modern synchrotron experiments, x-ray diffraction theory and semiconductor technology during the project.Read moreRead less