Discovery Early Career Researcher Award - Grant ID: DE120102352
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Three-dimensional structural imaging in optical microscopy and tomography. This project will develop fundamentally new strategies for looking inside live cells to determine their internal structures. Such capability will permit a better understanding of diseases, the link between diabetes and heart failure for example, opening the door for new diagnostic techniques and treatments.
Worldwide Collaboration for the Creation of New Frequency Standards, and their Application to testing the Foundations of Physics. Frequency standards are crucial for the highest precision scientific measurements as well as in modern communication and information technology (C&IT). Having already achieved world-best performance for short-term frequency stability, our research team is seeking support to participate in a broad international program with three particular objectives:
(i) create ne ....Worldwide Collaboration for the Creation of New Frequency Standards, and their Application to testing the Foundations of Physics. Frequency standards are crucial for the highest precision scientific measurements as well as in modern communication and information technology (C&IT). Having already achieved world-best performance for short-term frequency stability, our research team is seeking support to participate in a broad international program with three particular objectives:
(i) create new frequency standards based on laser-cooled atoms,
(ii) develop femtosecond laser technology for generating low noise microwave and optical signals,
(iii) develop microwave technology suitable for operation in space.
Improved frequency standards will allow decisive measurements on several fundamental scientific questions, as well as leading to commercial applications in C&IT.
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Biomolecular optoelectronic materials and devices. The melanins are the molecules in our skin, eyes and hair that provide colour and protection from the sun. In addition to being important bio-molecules, they have properties which make them useful for high tech applications especially in electronics and optoelectronics. Unfortunately, our current understanding of these fascinating materials is poor. In our project we aim to solve this limiting problem. We will develop new science to explain thei ....Biomolecular optoelectronic materials and devices. The melanins are the molecules in our skin, eyes and hair that provide colour and protection from the sun. In addition to being important bio-molecules, they have properties which make them useful for high tech applications especially in electronics and optoelectronics. Unfortunately, our current understanding of these fascinating materials is poor. In our project we aim to solve this limiting problem. We will develop new science to explain their behaviour, and use this knowledge to create bio-compatible hi-tech materials and devices. We anticipate significant benefits from the perspectives of basic science and utilisation of biomaterials for new green technologies.Read moreRead less
Slow light in nanostructured materials. This project will introduce and demonstrate novel concepts for dynamically controlling the speed of light and manipulating optical pulses in specially designed nanoscale structures, making an essential step towards the creation of all-optical devices performing fast switching and processing of optical signals. These developments underpin the next generation of high-performance networks, promising to revolutionize global communications. This project will ke ....Slow light in nanostructured materials. This project will introduce and demonstrate novel concepts for dynamically controlling the speed of light and manipulating optical pulses in specially designed nanoscale structures, making an essential step towards the creation of all-optical devices performing fast switching and processing of optical signals. These developments underpin the next generation of high-performance networks, promising to revolutionize global communications. This project will keep Australia at the forefront of international research and provide training of students on breakthrough applications of photonics and nanotechnology, contributing to the uptake of frontier technologies by Australian industries for successful operation in a competitive global environment.Read moreRead less
Engineering phase and the flow of light in nanophotonics. Optical devices on the scale of only billionths of a meter impel photonic revolution in information technologies. The extraordinary sensitivity and tunability of light confined on nano-scale is caused by the yet unexplored and poorly understood world of tiniest flows of energy, the optical vortices. In this project we will learn to manipulate optical vortices with the light itself, introducing original concepts for intelligent engineering ....Engineering phase and the flow of light in nanophotonics. Optical devices on the scale of only billionths of a meter impel photonic revolution in information technologies. The extraordinary sensitivity and tunability of light confined on nano-scale is caused by the yet unexplored and poorly understood world of tiniest flows of energy, the optical vortices. In this project we will learn to manipulate optical vortices with the light itself, introducing original concepts for intelligent engineering of nano-elements of a photonic chip. This project will deliver underpinning knowledge, foremost practical expertise, and the prominent training of young researchers to secure Australia's international leadership in the rapidly growing and competitive field of nanophotonics.Read moreRead less
SILICON BASED PHOTONIC CRYSTALS FOR MONITORING BIOMOLECULAR INTERACTIONS. Two great goals of biomolecular science are to monitor biomolecular interactions in real time and with sufficient sensitivity to allow small amounts of biological material to be investigated. The achievement of these goals is limited by the methods of transducing these reactions. The aim of this multidisciplinary proposal is to overcome this limitation by developing photonic devices that exploit the unique properties of na ....SILICON BASED PHOTONIC CRYSTALS FOR MONITORING BIOMOLECULAR INTERACTIONS. Two great goals of biomolecular science are to monitor biomolecular interactions in real time and with sufficient sensitivity to allow small amounts of biological material to be investigated. The achievement of these goals is limited by the methods of transducing these reactions. The aim of this multidisciplinary proposal is to overcome this limitation by developing photonic devices that exploit the unique properties of nanoporous silicon. The hybridisation of DNA will be used as a model biorecognition reaction. Potential applications of these photonic devices are as highly sensitive affinity sensors and as tools for investigating the kinetics of biomolecular interactions.Read moreRead less
Targeted light - optical mode control at the nanoscale. Nanophotonics provides a path for controlling the interaction of light and matter at the nanoscale. Using spatially tailored laser beams to address nano-particles, this project aims to create new approaches for specifically targeting light with nano-scale precision, which has valuable potential applications in biosensing and communications.
Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible ....Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible with next-generation lab-on-a-chip technologies and permit rapid throughput diagnostics with potential applications in biomedicine and materials science. Expected project outcomes may also underpin fundamental advances in understanding the interaction of light with nanostructures.Read moreRead less
Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ....Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ability to capture images of a moving sample, this project will enable innovative biomedical and materials research studies, and develop new imaging technologies for use in security, hospitals and manufacturing. New methods of x-ray imaging will have wide-ranging benefits for society, the economy and healthcare.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100624
Funder
Australian Research Council
Funding Amount
$372,529.00
Summary
The impact of structural dynamics on three-dimensional bioimaging with X-ray free-electron lasers. X-ray lasers can potentially determine the structures of biological molecules that are inaccessible to existing techniques. Intense ultrafast pulses encode the structure via diffraction faster than damage processes rip the molecule apart. In fact, damage processes begin during diffraction and remain problematic. It is not known if damage will prevent the determination of molecular orientations, a c ....The impact of structural dynamics on three-dimensional bioimaging with X-ray free-electron lasers. X-ray lasers can potentially determine the structures of biological molecules that are inaccessible to existing techniques. Intense ultrafast pulses encode the structure via diffraction faster than damage processes rip the molecule apart. In fact, damage processes begin during diffraction and remain problematic. It is not known if damage will prevent the determination of molecular orientations, a critical step in the experimental design. This project will solve this problem with a statistical theory, probing the feasibility and accuracy of the technique. The newly developed theory will enable us to perform experiments capable of measuring the effects of damage in biological molecules, paving the way for new methods of structure determination.Read moreRead less