Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346515
Funder
Australian Research Council
Funding Amount
$507,000.00
Summary
Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in ....Fluorescence Detector for the Australian National Beamline Facility. X-ray absorption spectroscopy (XAS) is an extremely important synchrotron radiation tool for determining the local structure around an X-ray absorbing atom. This has many applications in the study of materials, minerals, metal complexes, and metalloproteins and can often be used to obtain information that is not available by other techniques, because structural information can be obtained in the solid or solution state and in mixtures. The current proposal is aimed at introducing new technology into the Australian National Beamline Facility that will greatly improve the quality and quantity of experiments that can be performed and extend studies into dilute solutions and protein samples.Read moreRead less
Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size dis ....Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size distributions from tropical to polar environments are expected to reveal these vital rates of pelagic ecosystems. The zooplankton rates will reveal, for the first time, the link between phytoplankton and fisheries, and will significantly improve ecosystem models and global assessments of environmental change.Read moreRead less
Special Research Initiatives - Grant ID: SR120200004
Funder
Australian Research Council
Funding Amount
$30,000,000.00
Summary
Australian Synchrotron Access Program. The Australian Synchrotron epitomises scientific research excellence in Australian and New Zealand. Its impact spans nearly every research sector. This proposal brings together over 30 Australian universities working together to ensure that world-class peer-reviewed science continues to be performed at the Australian Synchrotron.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239943
Funder
Australian Research Council
Funding Amount
$245,000.00
Summary
Access for Australian Researchers to Advanced Neutron-Beam Technique. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Aus ....Access for Australian Researchers to Advanced Neutron-Beam Technique. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australia's parnership with the world's most intense neutron source, ISIS in the UK, in order to sustain the considerable Australian scientific momentum which now relies on ISIS.
The outcome will be new science that cannot be generated solely within Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100027
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Australian National Facility for Noble-Gas Radio-Isotope Measurements. Australian national facility for noble-gas radio-isotope measurements:
This facility is designed to provide researchers with the ability to accurately date water and ice cores using the natural radio-isotopes in the sample. Radiocarbon dating has been a revolutionary tool in providing answers to a range of questions in anthropology, archaeology and the earth sciences. However, radiocarbon dating has a strong limitation in th ....Australian National Facility for Noble-Gas Radio-Isotope Measurements. Australian national facility for noble-gas radio-isotope measurements:
This facility is designed to provide researchers with the ability to accurately date water and ice cores using the natural radio-isotopes in the sample. Radiocarbon dating has been a revolutionary tool in providing answers to a range of questions in anthropology, archaeology and the earth sciences. However, radiocarbon dating has a strong limitation in that it can only date periods from 1000–50 000 years: the use of radioactive noble-gas isotopes can extend this range out to 1 year to 1 million years. This capability in the new facility is expected to support new understanding of processes in artesian reservoirs, ocean currents and geology that may affect questions of water availability, climate and environmental change.Read moreRead less
ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions i ....ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions in science. An essential function of the network will be introducing researchers end users to new tools and broadening the horizons of graduate students.Read moreRead less
Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will b ....Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will be combined with isotopic analysis to reveal how environmental and biological factors drive animal movements and impact habitat connectivity. In a world of vanishing top predators, it is imperative to understand system dynamics before we can evaluate the impact of species removal on ecosystem function.Read moreRead less
Designing and Building Novel 2D Hybrid Materials. The aim of this project is to use computational and experimental techniques to discover and fabricate new hybrid materials. Single-layer (2-D) materials like graphene have gained prominence and new ones are constantly being reported. Hybrid materials built from combinations of 2-D layers are appearing but progress is slow. This project is designed to increase the rate of discovery and fabrication of hybrids. The outcome would be an extensive data ....Designing and Building Novel 2D Hybrid Materials. The aim of this project is to use computational and experimental techniques to discover and fabricate new hybrid materials. Single-layer (2-D) materials like graphene have gained prominence and new ones are constantly being reported. Hybrid materials built from combinations of 2-D layers are appearing but progress is slow. This project is designed to increase the rate of discovery and fabrication of hybrids. The outcome would be an extensive database of materials properties, clear direction on how to control material properties, and manufacturing protocols to build a wide range of new materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882778
Funder
Australian Research Council
Funding Amount
$201,224.00
Summary
Water vapour radiometers for millimetre-wave phase correction for the Australia Telescope. Australia has a tradition of excellence in astronomy. Inspired by wonder about the cosmos, it stimulates public interest in science, so leading to the training of highly skilled graduates. In turn, this drives the development of technologies needed to pursue the science. The nation has invested in the technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. This equipm ....Water vapour radiometers for millimetre-wave phase correction for the Australia Telescope. Australia has a tradition of excellence in astronomy. Inspired by wonder about the cosmos, it stimulates public interest in science, so leading to the training of highly skilled graduates. In turn, this drives the development of technologies needed to pursue the science. The nation has invested in the technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. This equipment will capitalise on this investment, extending the capabilities of the Australia Telescope to maintain it as a front line instrument, attracting the best scientists here to use it. This will help nurture a vigorous radio-science community, one able to actively participate in the billion-dollar investment being made internationally in the field.Read moreRead less