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Chemical Aided Phospoproteome Sequencing With Mass Spectrometry
Funder
National Health and Medical Research Council
Funding Amount
$141,000.00
Summary
Essentially all of the body's functions from muscle contraction, energy expenditure through to appetite are controlled by a complex molecular communications system. One of the key elements involves the modification of proteins to alter their properties by adding and removing phosphate. By analysing this process in response to diet and exercise we will obtain a greater understanding of their health benefits and understand how type 2 diabetes and obesity develop at the molecular level.
A New Approach To Explore The Role Of Selenoproteins In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$374,284.00
Summary
Selenoproteins play an important role in a variety of major diseases. Yet knowledge of the biology of selenium and its role in disease prevention and progression is not sufficient to recommend selenium supplementation for disease prevention or treatment. The broad aim of this research is to identify and characterise the response of selenoproteins to selenium supplementation and disease states.
Physical Activity And Mental Health: Developing Effective Interventions For Disadvantaged Youth
Funder
National Health and Medical Research Council
Funding Amount
$336,248.00
Summary
Adolescent physical inactivity is increasing in developing countries and contributes to poor physical and mental health. Latin American countries have developed successful methods to promote physical activity. The aim of this research is to assess if the Latin American approach is effective at improving the physical and mental health of Ugandans and Indigenous Australians. The results will indicate if these methods for promoting physical activity should be tried in other disadvantaged settings.
The Feasibility Of Introducing A Targeted Physical And Cognitive Activity Programme In For Patients In Intensive Care
Funder
National Health and Medical Research Council
Funding Amount
$216,463.00
Summary
Survival from critical illness can be associated with a legacy of physical weakness, inability to think clearly and anxiety; patients can’t function as they once did. I am a physiotherapist focused on improving the outcomes of survivors of intensive care. I intend to develop a physical and cognitive activity programme that can be commenced early in the intensive care unit (ICU) admission aimed at improving the devastating effects that an ICU admissions can have on physical and mental function.
Disarming Deadly Viruses: High Throughput Protease Screening Using Massive Peptide Libraries
Funder
National Health and Medical Research Council
Funding Amount
$405,625.00
Summary
Viral diseases affect millions of people worldwide with mortality rates as high as 50%. Viral enzymes help liberate proteins essential for viral replication. The rapid identification of the activity and specificity of these viral enzymes is important to combat outbreaks of viral disease and has become possible through biomedical device technology developed by the industry partner. With just 17 new drugs approved by the FDA in 2002, the proposed program has the potential to deliver new drugs quic ....Viral diseases affect millions of people worldwide with mortality rates as high as 50%. Viral enzymes help liberate proteins essential for viral replication. The rapid identification of the activity and specificity of these viral enzymes is important to combat outbreaks of viral disease and has become possible through biomedical device technology developed by the industry partner. With just 17 new drugs approved by the FDA in 2002, the proposed program has the potential to deliver new drugs quickly and efficiently, and this will be of benefit to viral disease sufferers worldwide.Read moreRead less
Translating A Drop Of Blood Into Effective Antibiotic Dosing In Infants And Children
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The optimal use of currently available antibiotics is of utmost importance at a time when few new antibiotics are being developed and there is a continued emergence of antibiotic resistant ‘superbugs’. This Fellowship will establish evidence-based, effective antibiotic dosing regimens for children with severe infection - using just a drop of blood. By applying innovation in microsampling, my research will advance our treatment of infection and result in better outcomes for sick children.
An Exploration Of The Interface Between Indigenous Knowledge And Anti-cancer Potential Of Traditionally Used Plants.
Funder
National Health and Medical Research Council
Funding Amount
$308,954.00
Summary
This research is directed towards embedding a model that enables the integration of Indigenous and Western-scientific knowledge of medicinal plants with anti-cancer properties or desirable bioactivities which may be associated with relieving the side effects of cancer treatment. Improved relationship and capacity building will be achieved through social engagement activties between Indigenous and Western researchers by teaching scientific related skills and knowledge related to practices conduct ....This research is directed towards embedding a model that enables the integration of Indigenous and Western-scientific knowledge of medicinal plants with anti-cancer properties or desirable bioactivities which may be associated with relieving the side effects of cancer treatment. Improved relationship and capacity building will be achieved through social engagement activties between Indigenous and Western researchers by teaching scientific related skills and knowledge related to practices conducted on traditional homelands.Read moreRead less
Design And Evaluation Of Inhibitors Targeting Serine Proteases In Blood To Alleviate Systemic Inflammatory Response To Coronary Artery Bypass Graft Surgery
Funder
National Health and Medical Research Council
Funding Amount
$317,559.00
Summary
Over 20,000 Australians undergo bypass surgery each year with a 3% mortality rate linked to complications from the procedure. One such common complication is caused by the body’s immune system being activated when the blood comes in contact with the blood bypass pump machine. This project aims to develop new medicines to block this activation of the immune system during bypass surgery to reduce complications and mortality associated with this procedure.
The Development Of Selective And Potent Kv1.3 Ion Channel Blockers For The Treatment Of Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$233,187.00
Summary
Building on the well-established path of developing drugs from Nature, the amplification of some unusual qualities of a naturally-occurring substance, khellinone, could lead to new treatments for autoimmune diseases such as multiple sclerosis and diabetes. Designed variants of khellinone are known to be very effective at preventing the destructive impact of the body's own T cells on the central nervous system that occurs in autoimmune disease.