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Discovery Early Career Researcher Award - Grant ID: DE230101504
Funder
Australian Research Council
Funding Amount
$438,026.00
Summary
Crossing restrictive biobarriers with self-assembled lipid nanocarriers. This project aims to determine how nanoscale objects which mimic the surface of cells behave in biologically relevant environments. This project expects to generate new knowledge in physical chemistry by complementing innovative surface chemistry design and characterisation with data science approaches. The expected outcome of this project is identification of the mode of interaction of these biomimetic objects with cells, ....Crossing restrictive biobarriers with self-assembled lipid nanocarriers. This project aims to determine how nanoscale objects which mimic the surface of cells behave in biologically relevant environments. This project expects to generate new knowledge in physical chemistry by complementing innovative surface chemistry design and characterisation with data science approaches. The expected outcome of this project is identification of the mode of interaction of these biomimetic objects with cells, which may then reveal a new pathway for the delivery of pharmaceuticals. This could provide significant future benefits in the treatment of neurological diseases and bacterial infections, by overcoming the barrier that the cell surface presents to the uptake of many medicinal drugs.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100732
Funder
Australian Research Council
Funding Amount
$359,544.00
Summary
Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at in ....Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at interfaces, the rate and the selectivity of chemical processes can be altered at will. The project intends to test these theoretical findings. The knowledge generated by this research may translate into new technologies for the fine-chemical and biotechnology industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101578
Funder
Australian Research Council
Funding Amount
$393,116.00
Summary
Quantitative structure-property relations for molecular crystals. Most of the known molecular compounds exist in crystalline form, and their stability and properties depend upon the structure and interactions in crystals. This project aims to develop methods in the field of quantum crystallography to accurately estimate the electronic properties of molecular crystals, their stability, and associated energetics. The outcomes will be directly applicable in the design of new solid-state forms of ph ....Quantitative structure-property relations for molecular crystals. Most of the known molecular compounds exist in crystalline form, and their stability and properties depend upon the structure and interactions in crystals. This project aims to develop methods in the field of quantum crystallography to accurately estimate the electronic properties of molecular crystals, their stability, and associated energetics. The outcomes will be directly applicable in the design of new solid-state forms of pharmaceutical drugs with enhanced solubility and efficacy and hence reduced drug dosage. Understanding the electronic properties in molecular semiconductor crystals, and the strategies to tune and control these properties will contribute to future generation electronic device material manufacturing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101194
Funder
Australian Research Council
Funding Amount
$353,700.00
Summary
A chirped pulse microwave spectrometer for studying atmospheric chemistry. This project aims to construct a microwave spectrometer with a unique molecular source to study atmospheric chemistry. Criegee intermediates formed by the ozonolysis of terpenes are key species in atmospheric chemical processes. Only very recently have small Criegee intermediates been detected by various spectroscopic methods. In this project a purpose-built chirped, pulsed Fourier transform microwave spectrometer will be ....A chirped pulse microwave spectrometer for studying atmospheric chemistry. This project aims to construct a microwave spectrometer with a unique molecular source to study atmospheric chemistry. Criegee intermediates formed by the ozonolysis of terpenes are key species in atmospheric chemical processes. Only very recently have small Criegee intermediates been detected by various spectroscopic methods. In this project a purpose-built chirped, pulsed Fourier transform microwave spectrometer will be coupled with a specialised molecular source that will enable their direct observation and characterisation by rotational spectroscopy. This will allow the structure of these molecules to be determined, which will provide insights into their reaction mechanisms.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100748
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Mechanofluorescent Surfaces for Understanding Complex Cell Traction Forces. This project aims to develop pressure-sensing surfaces that directly quantify surface forces, focused towards measuring complex cell traction forces. Understanding cell traction forces is a crucial challenge towards developing new materials for regenerative medicine. The surfaces, consisting of fluorescent polymer brushes, are expected to provide direct information on singular and clustered cell forces, which can reveal ....Mechanofluorescent Surfaces for Understanding Complex Cell Traction Forces. This project aims to develop pressure-sensing surfaces that directly quantify surface forces, focused towards measuring complex cell traction forces. Understanding cell traction forces is a crucial challenge towards developing new materials for regenerative medicine. The surfaces, consisting of fluorescent polymer brushes, are expected to provide direct information on singular and clustered cell forces, which can reveal new insight into how cells interact together. This may provide currently missing information on how cell-surface interaction forces modulate cell growth, differentiation and tissue formation. This insight is crucial to providing the underpinning science that can position Australia at the forefront of regenerative medicine.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101456
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Electrochemical behaviour of toxic gases and explosives in room temperature ionic liquids. This project will examine the behaviour of toxic gases and volatile explosive materials in ionic liquids. The information generated from this work will provide fundamental knowledge that will allow for the design of improved sensors for toxic gases, nerve agents and explosives, for applications in the mining and security sectors.
Discovery Early Career Researcher Award - Grant ID: DE130100970
Funder
Australian Research Council
Funding Amount
$370,600.00
Summary
Solar energy conversion: illuminating the origin of long-lived charge-separated states in organic donor/acceptor blends. The origin of exceptionally long-lived charges in organic donor/acceptor solid-state blends will be established. This will substantially enhance the efficiency and commercial viability of applications that rely on these long-lived charge-separated states, such as organic solar cells.
Discovery Early Career Researcher Award - Grant ID: DE200101076
Funder
Australian Research Council
Funding Amount
$426,985.00
Summary
Resolving nanoscale structure-activity for rational electrocatalyst design. This project aims to investigate the structural and functional properties of electrocatalysts at the nanoscale. The project expects to develop state-of-the-art electrochemical imaging technology that can examine the active sites of electrodes during operation. Understanding electrode performance on this scale is expected to enhance our capability to rationally design cheaper and more-efficient electrocatalysts, notably ....Resolving nanoscale structure-activity for rational electrocatalyst design. This project aims to investigate the structural and functional properties of electrocatalysts at the nanoscale. The project expects to develop state-of-the-art electrochemical imaging technology that can examine the active sites of electrodes during operation. Understanding electrode performance on this scale is expected to enhance our capability to rationally design cheaper and more-efficient electrocatalysts, notably for electrochemical carbon dioxide reduction. This should provide significant socio-economic and environmental benefits, through the development of next-generation energy storage and conversion materials that can be utilized by households and businesses to store renewable energy in the form of carbon-neutral fuels.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100065
Funder
Australian Research Council
Funding Amount
$423,808.00
Summary
Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body ....Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body - even water - into visible tracers. The expected outcomes of this project include the synthesis and understanding of these catalysts which will be chemically fine-tuned to maximise their effectiveness. Potential benefits include translation to MRI applications to improve diagnosis and treatment, or chemical monitoring.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100596
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Lithium-Ion Conducting Sulfide Cathodes for All-Solid-State Li–S Batteries. The aim of the project is to develop lithium-ion conducting sulphide cathode materials for high-performance all-solid-state lithium-sulphur (Li–S) batteries. Substituting solid-state electrolyte for liquid electrolyte is the most efficient approach to eliminate the polysulfide shuttle effect, which is the biggest obstacle for the practical application of Li–S batteries based on liquid electrolytes. The project aims to de ....Lithium-Ion Conducting Sulfide Cathodes for All-Solid-State Li–S Batteries. The aim of the project is to develop lithium-ion conducting sulphide cathode materials for high-performance all-solid-state lithium-sulphur (Li–S) batteries. Substituting solid-state electrolyte for liquid electrolyte is the most efficient approach to eliminate the polysulfide shuttle effect, which is the biggest obstacle for the practical application of Li–S batteries based on liquid electrolytes. The project aims to develop novel Li2S-rich cathode materials with high lithium-ion conductivity, which will form the basis of all-solid-state Li–S batteries with high energy density. The new battery is expected to have wide applications in portable electronic devices, electric vehicles and grid-scale renewable energy storage.Read moreRead less