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Bimolecular chemistry at very low temperatures. Many chemical reactions involve short-lived and highly reactive intermediates that cannot be observed under ordinary reaction conditions. Hence, much of this chemistry is shrouded in mystery. This project aims to develop the ability to observe and monitor such reactions directly using a combination of spectroscopies at very low temperatures, where the molecules are more stable and reactions slower. These studies will give quantitative information ....Bimolecular chemistry at very low temperatures. Many chemical reactions involve short-lived and highly reactive intermediates that cannot be observed under ordinary reaction conditions. Hence, much of this chemistry is shrouded in mystery. This project aims to develop the ability to observe and monitor such reactions directly using a combination of spectroscopies at very low temperatures, where the molecules are more stable and reactions slower. These studies will give quantitative information on the nature of the reactive intermediates themselves, the nature of the products formed, and the reaction dynamics, and they are of fundamental importance for an understanding of chemical reactivity generally. The methodology developed will be applicable to the investigation of a wide range of processes.Read moreRead less
New mechanisms and methods in carbene and nitrene chemistry. Carbenes and nitrenes are highly reactive intermediates of theoretical and mechanistic significance and synthetic versatility in organic chemistry. In spite of high reactivity, selective and high-yielding reactions can be performed, leading to products that may be difficult or impossible to synthesise by other methods. They have practical applications in photo-affinity labelling of biomolecules, and photolithography. This project will ....New mechanisms and methods in carbene and nitrene chemistry. Carbenes and nitrenes are highly reactive intermediates of theoretical and mechanistic significance and synthetic versatility in organic chemistry. In spite of high reactivity, selective and high-yielding reactions can be performed, leading to products that may be difficult or impossible to synthesise by other methods. They have practical applications in photo-affinity labelling of biomolecules, and photolithography. This project will contribute fundamental knowledge of the nature and reactions of these species by using direct spectroscopic observation. We are proposing the occurrence of novel types of reactions and the formation of several new reactive intermediates as well as a technique for the stabilization of reactive intermediates by incorporation into macrocyclic frameworks.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989946
Funder
Australian Research Council
Funding Amount
$357,000.00
Summary
High Resolution LC/MS and MALDI for Molecular and Macromolecular Characterisation. The provision of high-resolution and matrix assisted laser desorption ionisation mass spectrometers configured for the molecular and macromolecular research of high quality research groups will lead to earlier and better fundamental discoveries that are directed at important practical developments in medicine, biotechnology, nanotechnology, light-energy harvesting, polymer materials and sensors. These include anti ....High Resolution LC/MS and MALDI for Molecular and Macromolecular Characterisation. The provision of high-resolution and matrix assisted laser desorption ionisation mass spectrometers configured for the molecular and macromolecular research of high quality research groups will lead to earlier and better fundamental discoveries that are directed at important practical developments in medicine, biotechnology, nanotechnology, light-energy harvesting, polymer materials and sensors. These include anticancer agents, nanodevices for drug delivery, better polymers with more energy efficient industrial processes, bioactive molecules for industrially important nitrogen fixation and many more. Read moreRead less
Reactive intermediates and microwave-assisted organic reactions. The use of our chemistry to help develop new, safer, better drugs against schizophrenia is a strong driving force for this research. This relates to the National Research Priority of promoting and maintaining good health, ageing well and productively, and preventative healthcare. Microwave-assisted chemical synthesis will undoubtedly become a very important methodology in the pharmaceutical industry, and our work will help develop ....Reactive intermediates and microwave-assisted organic reactions. The use of our chemistry to help develop new, safer, better drugs against schizophrenia is a strong driving force for this research. This relates to the National Research Priority of promoting and maintaining good health, ageing well and productively, and preventative healthcare. Microwave-assisted chemical synthesis will undoubtedly become a very important methodology in the pharmaceutical industry, and our work will help developing such know-how in Australia and thereby contribute to the Australian economic fabric. Read moreRead less
Development of an Adjustable Porphyrin-based Molecular Platform for Nanotechnology Applications. Nanotechnology, the art of molecular control, is often heralded as the next industrial revolution. For this to be realised, the construction of useful devices will require precise control at the molecular level. Our control is realised through a process called self-assembly which means that the once the components of the device are correctly designed, the device will simply be able to put itself tog ....Development of an Adjustable Porphyrin-based Molecular Platform for Nanotechnology Applications. Nanotechnology, the art of molecular control, is often heralded as the next industrial revolution. For this to be realised, the construction of useful devices will require precise control at the molecular level. Our control is realised through a process called self-assembly which means that the once the components of the device are correctly designed, the device will simply be able to put itself together. This research will use nature's light harvesting elements, namely porphyrins, and our ability to precisely control their position with respect to each other to build new, more efficient solar cells.Read moreRead less
Development of microflow photochemistry and its application in the synthesis of platform chemicals of pharmaceutical interest. Light induces chemical changes with a 'flick of a switch'. Following the motto 'only as small as is necessary', the project will develop a new technology for conducting photoreactions in microspace. These microdevices will be used to construct a range of related compounds or to produce a bulk amount of a specific target molecule of pharmaceutical interest.
Computational tools for organic synthesis. This project aims to develop new computer modelling techniques with the ability to rapidly identify efficient synthetic routes to target molecules. The barrier heights, reaction energies, and product selectivities of the individual steps in a multi-step synthesis are key factors determining its overall efficiency, and are traditionally determined empirically. Innovative tools for predicting these properties through computer simulations are the expected ....Computational tools for organic synthesis. This project aims to develop new computer modelling techniques with the ability to rapidly identify efficient synthetic routes to target molecules. The barrier heights, reaction energies, and product selectivities of the individual steps in a multi-step synthesis are key factors determining its overall efficiency, and are traditionally determined empirically. Innovative tools for predicting these properties through computer simulations are the expected outcomes of this project. These tools are anticipated to enable target molecules to be accessed more efficiently, with less expenditure of laboratory resources and a lower environmental impact, thereby contributing to an agile and sustainable chemical industry.Read moreRead less
Environmentally sustainable asymmetric synthesis: design and development of chiral hydrogen bonding organocatalysts. There is a pressing need for more environmentally sustainable and economically viable methods for asymmetric synthesis. This project aims to design, synthesise and evaluate new organocatalysts based on the principle of hydrogen bonding activation, a common feature of Nature's catalysts, enzymes. These inexpensive, non-toxic, air- and moisture-stable catalysts may prove to be more ....Environmentally sustainable asymmetric synthesis: design and development of chiral hydrogen bonding organocatalysts. There is a pressing need for more environmentally sustainable and economically viable methods for asymmetric synthesis. This project aims to design, synthesise and evaluate new organocatalysts based on the principle of hydrogen bonding activation, a common feature of Nature's catalysts, enzymes. These inexpensive, non-toxic, air- and moisture-stable catalysts may prove to be more efficient, selective and have broader applicability than catalysts based on transition metals. The growing Australian pharmaceutical and biotechnology industries will benefit from the development of these new Advanced Materials and the training provided to young scientists in the sought-after fields of asymmetric synthesis and catalysis.Read moreRead less