Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provi ....Biodegradable polymeric microparticles for targeted delivery. The use of microparticles with tuneable physicochemical properties and loading characteristics is of interest in the fields of biomaterials, drug delivery and imaging. Such engineered particles are likely to address problems associated with conventional drugs and drug carriers, including poor disease site selectivity, polymer toxicity, non-biodegradability and free diffusion of drugs throughout the body. These microparticles may provide direct advantages to society, including minimally invasive and fast in-vivo diagnostics, localised delivery of drugs and therapeutic agents with increased bioavailability, patient acceptability and reduced healthcare costs.Read moreRead less
Electrochemistry of redox-active non-metal compounds. Unsaturated compounds of heavier non-metal elements can exist in multiple stable redox states. The interconversion is best assessed by electrochemical techniques, which can measure the energetics and the mechanism of the redox processes involved in both solution and solid state phases. Compounds to be studied will be prepared in the Canadian laboratories of the partner investigator. The electrochemical and spectroelectrochemical properties ....Electrochemistry of redox-active non-metal compounds. Unsaturated compounds of heavier non-metal elements can exist in multiple stable redox states. The interconversion is best assessed by electrochemical techniques, which can measure the energetics and the mechanism of the redox processes involved in both solution and solid state phases. Compounds to be studied will be prepared in the Canadian laboratories of the partner investigator. The electrochemical and spectroelectrochemical properties will initially be investigated in Australia during the visit of the partner investigator to Monash University with follow up studies in both countries. The mutual skills of synthesis and electrochemistry in the Canadian-Australian laboratories are essential to the project.Read moreRead less
Palaeoclimate reconstruction in northwestern China. Records of climatic change between semi-arid regions of the two large continents, China and Australia, provide invaluable data on the manner in which the globe has responded to past environmental changes. Such reconstructions impose constraints on possible patterns of future change.
The visit by an established researcher in Prof. Sun Jiamin will provide new data (including new dates) on the evolution of lakes and dunefields in China, and on ....Palaeoclimate reconstruction in northwestern China. Records of climatic change between semi-arid regions of the two large continents, China and Australia, provide invaluable data on the manner in which the globe has responded to past environmental changes. Such reconstructions impose constraints on possible patterns of future change.
The visit by an established researcher in Prof. Sun Jiamin will provide new data (including new dates) on the evolution of lakes and dunefields in China, and on the climatic conditions which controlled them. The visit builds on and extends the established links between the Chinese Academy of Sciences and staff in the Melbourne University, School of Earth Sciences.
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Sonochemical synthesis of nanoparticles for fuel cell applications. The sonochemical synthesis of metal and semiconductor nanoparticles is one of several developing applications of ultrasound. Ultrasonically produced nanoparticles possess a number of specific properties, such as, pronounced catalytic activity. This project aims to ultrasonically synthesize metal nanoparticles and evaluate their suitability for fuel cell applications. The University of Melbourne and the Indiana University Nor ....Sonochemical synthesis of nanoparticles for fuel cell applications. The sonochemical synthesis of metal and semiconductor nanoparticles is one of several developing applications of ultrasound. Ultrasonically produced nanoparticles possess a number of specific properties, such as, pronounced catalytic activity. This project aims to ultrasonically synthesize metal nanoparticles and evaluate their suitability for fuel cell applications. The University of Melbourne and the Indiana University North-West research groups have a strong background and experience in the proposed research field. The outcome of this investigation will provide the basis for gaining other funding (e.g., ARC-NSF), which will establish a more extensive longer term collaboration between the universities.Read moreRead less
Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Austral ....Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Australian scientists with their first access to x-ray microscopy at its optimum wavelength; and secondly it will provide a superb testbed for x-ray microscopy to be enhanced using unique methods being developed in Australia.Read moreRead less
Mechanisms for Improved Ductility of Magnesium Alloys. The work will lead to more ductile magnesium alloys. These alloys will be more readily formed into automotive components. The lighter cars that will result will be cheaper to run and more environmentally friendly. The exchange of key researchers that will occur under this proposal will provide an exciting injection of expertise into the partner organisations from which students will greatly benefit. The work will also open up access to state ....Mechanisms for Improved Ductility of Magnesium Alloys. The work will lead to more ductile magnesium alloys. These alloys will be more readily formed into automotive components. The lighter cars that will result will be cheaper to run and more environmentally friendly. The exchange of key researchers that will occur under this proposal will provide an exciting injection of expertise into the partner organisations from which students will greatly benefit. The work will also open up access to state-of-the-art equipment in the collaborating laboratories.Read moreRead less
Studying cell mechanics with a biophotonics-based tool. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to optimise ....Studying cell mechanics with a biophotonics-based tool. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to optimise conditioning protocols, thereby improving the properties of engineered tissue.
During this study we will develop optical tools that have applications in the life sciences, in the development of advanced materials and in nanotechnology. Our project will promote Australian research in these fields.Read moreRead less
Near-field Cosmology with Globular Clusters. Globular star clusters are the astronomical equivalent of fossils, and as such they provide unique insight into the early epochs of the Universe. This project will establish a link between two world-leading research groups in this area. This Australian-Canadian collaboration will train the next generation of PhD students, create innovative 3D visualisation applications and produce a book on globular clusters.
The Formation of the Most Massive Galaxies in the Universe. This program aims to solve the mystery of how the most massive
galaxies in the Universe formed. We will employ one of the world's
most powerful telescopes, and the observations will be compared with
cosmological simulations by a supercomputer. A state-of-art technique
will be used to analyse the galaxy dynamics, allowing the distribution
of the mysterious Dark Matter to be probed. The results will be the
deepest and most detailed ....The Formation of the Most Massive Galaxies in the Universe. This program aims to solve the mystery of how the most massive
galaxies in the Universe formed. We will employ one of the world's
most powerful telescopes, and the observations will be compared with
cosmological simulations by a supercomputer. A state-of-art technique
will be used to analyse the galaxy dynamics, allowing the distribution
of the mysterious Dark Matter to be probed. The results will be the
deepest and most detailed studies of this kind to date, with
wide-ranging implications for our current paradigm of galaxy formation
and evolution.
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Production of a compact disk summarising the evolution and impact of Boger fluids. In 1977 the discovery of a unique class of materials, now called Boger fluids, was reported in the Journal of Non-Newtonian Fluid Mechanics. These materials have had a huge impact in the development of non-Newtonian fluid mechanics, to the extent that the Institute of Non-Newtonian Fluid Mechanics in the UK have offered to make a cd documenting the impact of these materials. Funding is requested to support, in p ....Production of a compact disk summarising the evolution and impact of Boger fluids. In 1977 the discovery of a unique class of materials, now called Boger fluids, was reported in the Journal of Non-Newtonian Fluid Mechanics. These materials have had a huge impact in the development of non-Newtonian fluid mechanics, to the extent that the Institute of Non-Newtonian Fluid Mechanics in the UK have offered to make a cd documenting the impact of these materials. Funding is requested to support, in part, the documentation of this important discovery.Read moreRead less