Visualising vascular adaptation at the micro-scale in humans. The project aims to investigate fundamental issues in the mechanisms underlying vascular remodelling. It plans to develop novel optical scanning techniques to acquire high-resolution images of the cutaneous microvasculature, alongside absolute blood flow quantification. These novel tools would allow us to visualise and quantify functional and structural adaptations in the microvasculature in response to physiological stimuli such as h ....Visualising vascular adaptation at the micro-scale in humans. The project aims to investigate fundamental issues in the mechanisms underlying vascular remodelling. It plans to develop novel optical scanning techniques to acquire high-resolution images of the cutaneous microvasculature, alongside absolute blood flow quantification. These novel tools would allow us to visualise and quantify functional and structural adaptations in the microvasculature in response to physiological stimuli such as heat exposure and exercise. The non-invasive tool aims to enable us to assess adaptations in microvasculature health, improving our understanding of cardiovascular diseases and type 2 diabetes and potentially reducing the impact of costly and debilitating morbidities such as nephropathy, neuropathy, retinopathy, impotence and skin ulceration.Read moreRead less
Defining the direct effects of exercise on arterial adaptation. Understanding the mechanisms responsible for the beneficial effects of exercise is fundamental to optimising the design of preventative programs aimed at healthy ageing. These experiments will contribute to our understanding of the direct effects of changes in blood flow and pressure during exercise on vascular adaptations in humans.
Impact of shear stress on vascular adaptations in humans. Large arteries are important for the delivery of blood and oxygen to organs such as the heart and brain. A primary physiological stimulus which controls the size and function of these crucial arteries is the magnitude of flow or, more accurately, shear force that the inner wall of the artery is exposed to. We have developed novel software which enables non-invasive assessment of arterial wall velocity, diameter and blood flow. We will ass ....Impact of shear stress on vascular adaptations in humans. Large arteries are important for the delivery of blood and oxygen to organs such as the heart and brain. A primary physiological stimulus which controls the size and function of these crucial arteries is the magnitude of flow or, more accurately, shear force that the inner wall of the artery is exposed to. We have developed novel software which enables non-invasive assessment of arterial wall velocity, diameter and blood flow. We will assess the impact of acute and chronic changes in wall flow and shear on arterial size and function. We will also develop new software which measures other aspects of artery wall behaviour. These basic human physiology studies have direct implications for assessment of artery health in humans.Read moreRead less
Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected ....Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected at a reasonable rate.Read moreRead less
Probing the internal contacts of all solid-state polymeric ion sensors. The results of this research will enable the development of robust and reliable all solid-state polymeric ion sensors. These sensors will enable solutions to significant environmental problems such as soil salinity and acidity, and may pave the way for new and exciting analytical applications, e.g., miniaturized implantable sensors for in-vivo use, microfluidics and Forensic Science, single blood droplet clinical analyzers, ....Probing the internal contacts of all solid-state polymeric ion sensors. The results of this research will enable the development of robust and reliable all solid-state polymeric ion sensors. These sensors will enable solutions to significant environmental problems such as soil salinity and acidity, and may pave the way for new and exciting analytical applications, e.g., miniaturized implantable sensors for in-vivo use, microfluidics and Forensic Science, single blood droplet clinical analyzers, rugged solid contact ion sensors for use in submersible oceanographic analyzers, etc. The research will develop a unique in-situ neutron reflectometry technique for the study of electrochemical interfaces, providing scientific opportunities for the new Australian Replacement Research Reactor.Read moreRead less
Probing the interfaces of electrochemical sensors. The nanostructured surfaces of electrochemical sensors for iron, mercury and cadmium will be characterised by using a range of state-of-the-art surface analysis techniques. Whilst electrochemical sensors are extremely valuable in monitoring of trace metals in the aquatic environment, a knowledge of the surface chemical physics of the systems is vital in order to widen their use in analytical/environmental chemistry. This project will derive a u ....Probing the interfaces of electrochemical sensors. The nanostructured surfaces of electrochemical sensors for iron, mercury and cadmium will be characterised by using a range of state-of-the-art surface analysis techniques. Whilst electrochemical sensors are extremely valuable in monitoring of trace metals in the aquatic environment, a knowledge of the surface chemical physics of the systems is vital in order to widen their use in analytical/environmental chemistry. This project will derive a universal model for the surface chemistry and physics of electrochemical sensors, enabling environmental scientists to develop unique sensor methods for studying the speciation of environmentally important trace metals such as those mentioned above.Read moreRead less
Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed u ....Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed us about the strength of the bonds, others have told us where the bonds occur. This project will provide both pieces of information for the first time, allowing us to better understand, and therefore control, biological function. This work will assist in the development of new biotechnology processes, especially in the emerging area of proteomics.Read moreRead less
Precision time and frequency in the lab and in space to test fundamental physics. This project gives Australia the opportunity to be involved in the world's best time comparison experiment ever conceived using the European Space Agency's ultra-accurate atomic clocks in space and the best international network of ground clocks. It strengthens collaboration between the University of Western Australia and world elite metrology institutes, including Paris Observatory, Ecole Normale Superior, the Nat ....Precision time and frequency in the lab and in space to test fundamental physics. This project gives Australia the opportunity to be involved in the world's best time comparison experiment ever conceived using the European Space Agency's ultra-accurate atomic clocks in space and the best international network of ground clocks. It strengthens collaboration between the University of Western Australia and world elite metrology institutes, including Paris Observatory, Ecole Normale Superior, the National Measurement Institute, the French Space Agency, and Humboldt, Stanford and Durham Universities. It involves cutting edge research that will test relativity, particle physics and fundamental constants that may well lead to fundamental changes to our laws of Nature and the Universe.Read moreRead less
Extending the spectrum and performance of ultra-stable frequency generation. Precision oscillators developed at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, VLBI, tests of fundamental physics etc., and have attracted worldwide interest. This project will strengthen Australian 'know how' and extend our expertise into new frequency bands essential for space communications and high frequency rad ....Extending the spectrum and performance of ultra-stable frequency generation. Precision oscillators developed at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, VLBI, tests of fundamental physics etc., and have attracted worldwide interest. This project will strengthen Australian 'know how' and extend our expertise into new frequency bands essential for space communications and high frequency radio Astronomy. This will include necessary international collaboration with world elite institutes.Read moreRead less
MODAL AND DIRECTIONAL CHARACTERISTICS OF SEASTATES AND THEIR IMPACT ON DYNAMICS OF MOORED OFFSHORE SYSTEMS. Under certain conditions a typical sea can becomes bimodal comprising of wind-driven seas and long period swells interacting from two directions. Using a nonlinear model, the occurrence and characteristics of bimodal and bi-directional seastates are quantified.
Low frequency oscillations of a moored offshore structure have profound design influence on the mooring system. A nonlinear res ....MODAL AND DIRECTIONAL CHARACTERISTICS OF SEASTATES AND THEIR IMPACT ON DYNAMICS OF MOORED OFFSHORE SYSTEMS. Under certain conditions a typical sea can becomes bimodal comprising of wind-driven seas and long period swells interacting from two directions. Using a nonlinear model, the occurrence and characteristics of bimodal and bi-directional seastates are quantified.
Low frequency oscillations of a moored offshore structure have profound design influence on the mooring system. A nonlinear response model for a floating vessel in bimodal and bi-directional seastates, will be developed using nonlinear dynamics techniques. The numerical models for the environment and the floating platform will be validated by experiments at the Ocean Basin in Canada.
The project adopts a holistic approach by considering the environment and the moored platform as a complex natural system. With excellent opportunities for technology transfer, the project also benefits from substantial in-kind contributions of the overseas PIs.
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