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STABILISATION OF TITANIA PIGMENTS FOR IMPROVED WATER-BASED PAINT APPLICATIONS. This project aims to improve the stability and optical properties of titania pigments in water-based paints. Tailored dispersing agents will be used to stabilise pigments in paints in both the wet and dry state. Enhanced understanding of the dispersing agents interaction with the titania pigment surface and the subsequent stability of the pigment in dry paint films will allow advances in water-based paint stability. T ....STABILISATION OF TITANIA PIGMENTS FOR IMPROVED WATER-BASED PAINT APPLICATIONS. This project aims to improve the stability and optical properties of titania pigments in water-based paints. Tailored dispersing agents will be used to stabilise pigments in paints in both the wet and dry state. Enhanced understanding of the dispersing agents interaction with the titania pigment surface and the subsequent stability of the pigment in dry paint films will allow advances in water-based paint stability. This understanding facilitates continued movement away from solvent-based paints required by environmental and health legislation. The potential growth in market share for the Australian pigment industry is in excess of $50M pa.Read moreRead less
Calcification of acrylic hydrogels in abiotic media: mechanism and control. Poly(2-hydroxyethyl methacrylate (PHEMA) and other acrylic hydrogels are extensively used as biomaterials, yet conclusive evidence exists that they have a propensity to calcify following implantation. This process has undesirable consequences on the functionality of various prostheses. Based on preliminary observations that PHEMA can promote the deposition of calcium minerals from media devoid of biological factors, whic ....Calcification of acrylic hydrogels in abiotic media: mechanism and control. Poly(2-hydroxyethyl methacrylate (PHEMA) and other acrylic hydrogels are extensively used as biomaterials, yet conclusive evidence exists that they have a propensity to calcify following implantation. This process has undesirable consequences on the functionality of various prostheses. Based on preliminary observations that PHEMA can promote the deposition of calcium minerals from media devoid of biological factors, which appears thus to be an inherent property of the polymer, the project aims at formulating new hypotheses to explain this phenomenon, and to confirm them experimentally. The "chelation" hypothesis will be validated by modifying the structure of polymers, and the "spontaneous precipitation" hypothesis by assessing the effect of solutes on the equilibrium water content of polymers. NMR and FTIR spectrometric techniques will be used to gain further insight into the mechanism of calcification. Methods to prevent the calcification will potentially result from these experiments, however, anticalcification agents will also be incorporated into hydrogels and their effect evaluated in calcification assays.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775650
Funder
Australian Research Council
Funding Amount
$170,000.00
Summary
Advanced multi-purpose analytical pyrolysis facility. Investment by the ARC, two WA universities, a government research agency, a CRC (and idirectly by a water utility) demonstrate the national need for this analytical facility and the broad commitment to maintain Australia's reputation in the field of analytical pyrolysis. An innovative laser micropyrolysis facility will be concurrently used with a recent commercially available unit to support research of present day and palaeo-environmental o ....Advanced multi-purpose analytical pyrolysis facility. Investment by the ARC, two WA universities, a government research agency, a CRC (and idirectly by a water utility) demonstrate the national need for this analytical facility and the broad commitment to maintain Australia's reputation in the field of analytical pyrolysis. An innovative laser micropyrolysis facility will be concurrently used with a recent commercially available unit to support research of present day and palaeo-environmental occurrences of OM, directly assisting an eclectic range of research activities including environmental protection and petroleum exploration. This facility will also aid the chemical fingerprinting of minute forensic evidence, ultimately helping to convict perpetrators of crime.
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Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The ....Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The current study will investigate the structural and biophysical properties of a recently discovered HuR/PCBP/mRNA complex implicated in the regulation of androgen receptor expression. This information has the potential to assist in the development of drugs to reduce AR expression in prostate cancer.Read moreRead less
Ionic lquids for scalable production of monolayer two-dimensional materials. This project aims to produce stable solutions of high quality, two-dimensional materials (2DMs, exemplified by graphene) in ionic liquids by spontaneous exfoliation. The project will develop processes for producing significant quantities of high quality 2DMs for use in a diverse range of technologies, and train graduate students in experimental and computational chemistry techniques.
Biodegradable Porous HEMA-Based Polymers: Innovative Strategies for the Design and Tuneable Single-Step Production of a Novel Class of Scaffolds for Tissue Engineering. This project will lead to the development of new biocompatible, biodegradable, porous materials ideally suited to many applications in tissue engineering. These new biomaterials will be relatively inexpensive to manufacture, via simple processes using non-toxic reagents. The key properties of the biomaterials will be controllable ....Biodegradable Porous HEMA-Based Polymers: Innovative Strategies for the Design and Tuneable Single-Step Production of a Novel Class of Scaffolds for Tissue Engineering. This project will lead to the development of new biocompatible, biodegradable, porous materials ideally suited to many applications in tissue engineering. These new biomaterials will be relatively inexpensive to manufacture, via simple processes using non-toxic reagents. The key properties of the biomaterials will be controllable by appropriate choice of starting materials. The availability of these new biomaterials will facilitate future developments in tissue engineering, which will ultimately lead to improved medical outcomes in areas as diverse as joint and bone repair and organ regeneration. Local manufacture of these biomaterials would also contribute to the development of the Australian biotechnology industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346892
Funder
Australian Research Council
Funding Amount
$689,000.00
Summary
Protein Over-Expression/Purification and Macromolecular Structure Determination by X-Ray Diffraction. This proposal seeks funds for state-of-the-art facilities for protein over-expression and macromolecular X-ray diffraction. This will build upon recent initiatives within the collaborating institutions in the field of Structural Biology. It will enable research groups in Perth to pursue the large-scale production of important proteins and to conduct high-resolution structural studies using X-ray ....Protein Over-Expression/Purification and Macromolecular Structure Determination by X-Ray Diffraction. This proposal seeks funds for state-of-the-art facilities for protein over-expression and macromolecular X-ray diffraction. This will build upon recent initiatives within the collaborating institutions in the field of Structural Biology. It will enable research groups in Perth to pursue the large-scale production of important proteins and to conduct high-resolution structural studies using X-ray crystallographic techniques. This technology, which is one of the most important tools in modern biology, provides unique insights into the chemical mechanisms of biological macromolecules and will significantly enhance a great breadth of biological research in Western Australia.Read moreRead less
Development of Dry Coated Pigment Particles: Durability and Dispersion. Tiwest is the only business in the world that mines, separates, refines and manufactures titanium dioxide products in one region. Tiwest has a major impact on the Western Australian economy with more than 700 full time and contract jobs, export earnings of $400M (in 2004) and regular incomes for an estimated 500 businesses. The current wet pigment particle coating process, to ensure ease of handling and longevity, is a major ....Development of Dry Coated Pigment Particles: Durability and Dispersion. Tiwest is the only business in the world that mines, separates, refines and manufactures titanium dioxide products in one region. Tiwest has a major impact on the Western Australian economy with more than 700 full time and contract jobs, export earnings of $400M (in 2004) and regular incomes for an estimated 500 businesses. The current wet pigment particle coating process, to ensure ease of handling and longevity, is a major cost. An optimised pigment dry-coating process would ensure Tiwest's competitiveness through reduced processing costs and improved performance. This development has the potential to increase Tiwest's profitability by 10%.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101578
Funder
Australian Research Council
Funding Amount
$393,116.00
Summary
Quantitative structure-property relations for molecular crystals. Most of the known molecular compounds exist in crystalline form, and their stability and properties depend upon the structure and interactions in crystals. This project aims to develop methods in the field of quantum crystallography to accurately estimate the electronic properties of molecular crystals, their stability, and associated energetics. The outcomes will be directly applicable in the design of new solid-state forms of ph ....Quantitative structure-property relations for molecular crystals. Most of the known molecular compounds exist in crystalline form, and their stability and properties depend upon the structure and interactions in crystals. This project aims to develop methods in the field of quantum crystallography to accurately estimate the electronic properties of molecular crystals, their stability, and associated energetics. The outcomes will be directly applicable in the design of new solid-state forms of pharmaceutical drugs with enhanced solubility and efficacy and hence reduced drug dosage. Understanding the electronic properties in molecular semiconductor crystals, and the strategies to tune and control these properties will contribute to future generation electronic device material manufacturing.Read moreRead less