Neutron Scattering in Biology. Australia's Replacement Research Reactor will be a world-class neutron source, and represents the country's largest single investment in scientific research infrastructure. It is now essential to stimulate its production of high-quality research in materials science, chemistry and biology. The applicant is a recognised world leader in the field of neutron scattering research, particularly in biology. His presence in the Bragg Institute, which manages the neutron ....Neutron Scattering in Biology. Australia's Replacement Research Reactor will be a world-class neutron source, and represents the country's largest single investment in scientific research infrastructure. It is now essential to stimulate its production of high-quality research in materials science, chemistry and biology. The applicant is a recognised world leader in the field of neutron scattering research, particularly in biology. His presence in the Bragg Institute, which manages the neutron scattering instruments on the reactor, will provide direction and impetus for the science that will be initiated there, advancing applications in materials science, medicine and biotechnology.Read moreRead less
Biocompatible Ionic Liquids - Preserving Bioactive Structure and Function. A family of liquids recently discovered at Monash University has an ability to preserve bioactive molecules that represents a breakthrough in biotechnology. These new biocompatible ionic liquids will be investigated for applications in the treatment of diseases such as haemophilia. The ability of these liquids to stabilise a wide range of enzymes also opens up the potential of their use in a range of biosensors such as b ....Biocompatible Ionic Liquids - Preserving Bioactive Structure and Function. A family of liquids recently discovered at Monash University has an ability to preserve bioactive molecules that represents a breakthrough in biotechnology. These new biocompatible ionic liquids will be investigated for applications in the treatment of diseases such as haemophilia. The ability of these liquids to stabilise a wide range of enzymes also opens up the potential of their use in a range of biosensors such as blood glucose monitors for diabetes management. In collaborations with research groups worldwide, these materials will also be applied to the preservation of bioactivity in applications including cryopreservation of endangered species such as coral and in medical therapeutics. Read moreRead less
Manipulation of Nano-Scale Assembly, Structure and Interaction: New Drug Delivery Vehicles and Energy Storage Devices for Miniaturised Portable Electronic Products. Nano-scale molecular and surface interactions will be manipulated to develop new nano-structured products. There will be two themes of research activity. In the first theme, newly discovered ionic liquids will be employed to better elucidate the role of hydrophobic interaction in molecular assembly processes. These findings wil ....Manipulation of Nano-Scale Assembly, Structure and Interaction: New Drug Delivery Vehicles and Energy Storage Devices for Miniaturised Portable Electronic Products. Nano-scale molecular and surface interactions will be manipulated to develop new nano-structured products. There will be two themes of research activity. In the first theme, newly discovered ionic liquids will be employed to better elucidate the role of hydrophobic interaction in molecular assembly processes. These findings will assist in the development of surfactant-drug conjugates that can self-assemble and can converge therapeutic, drug delivery and controlled release functions; allowing drugs to be administered in the therapeutic concentration range for prolonged periods of time with reduced side-effects. In the second theme, nano-materials will be used to converge capacitor and battery technologies to provide a dramatic performance boost to miniaturised portable electronic devices.Read moreRead less
New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modificatio ....New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modification, as a basis for high-throughput mass spectrometrical analyses;
- development of an algorithm for rapid resonance assignment of 15N-labelled proteins which is of importance for the pharmaceutical industry;
- 3D structure determinations of proteins and protein domains.Read moreRead less
Closing the Future: New Foundations for the Physics of Possibility. The distinction between a fixed and an open future is deeply embedded in human thought, and also central to some of the most profound puzzles in contemporary physics. By revealing the human origins of out fundamental concepts of possibility in time, this project will enhance our understanding of one of the most basic features of our experience of the world, lay foundations for a new treatment of time and possibility in foundame ....Closing the Future: New Foundations for the Physics of Possibility. The distinction between a fixed and an open future is deeply embedded in human thought, and also central to some of the most profound puzzles in contemporary physics. By revealing the human origins of out fundamental concepts of possibility in time, this project will enhance our understanding of one of the most basic features of our experience of the world, lay foundations for a new treatment of time and possibility in foundamental physics, and throw important new light on the mysteries of the quantum world.Read moreRead less
Advanced products through multiscale microstructure engineering. The metals manufacturing industry is one of the most important in Australia. Future growth and sustainability of the sector is critically dependent on the development of innovative metal products and materials.. In this program Australia's leading research group in metal manufacturing will develop new products and processes through the controlled manipulation of the microstructure at a number of levels: from nano scale to macro s ....Advanced products through multiscale microstructure engineering. The metals manufacturing industry is one of the most important in Australia. Future growth and sustainability of the sector is critically dependent on the development of innovative metal products and materials.. In this program Australia's leading research group in metal manufacturing will develop new products and processes through the controlled manipulation of the microstructure at a number of levels: from nano scale to macro scale. The areas of application include the automotive industry, biomaterials, surface engineering and the emerging area of microforming technologiesRead moreRead less
Self organization in (bio)molecular systems: Simulating the folding and aggregation of peptides, proteins and lipids. Molecular self-assembly is a basic property of living systems. Most proteins fold spontaneously and then further self-organize into functional complexes, effectively biological machines. Understanding how this occurs is a fundamental theoretical challenge with widespread application. Work will focus on developing methodology to simulate, computationally, the folding and aggrega ....Self organization in (bio)molecular systems: Simulating the folding and aggregation of peptides, proteins and lipids. Molecular self-assembly is a basic property of living systems. Most proteins fold spontaneously and then further self-organize into functional complexes, effectively biological machines. Understanding how this occurs is a fundamental theoretical challenge with widespread application. Work will focus on developing methodology to simulate, computationally, the folding and aggregation of peptides, proteins, and lipids. The aim is to accurately predict the structures of small peptides in solution and to refine crude models of larger molecules (complexes). This will facilitate the development of peptide based therapeutics and is essential in exploiting the growing volume of genetic information in biology and medicine.Read moreRead less
Origin and Evolution of the Earth's Chemical Reservoirs. The scientific aims of this project are to understand the processes by which the Earth separated into its chemically-distinct layers (core, mantle, crust, atmosphere, oceans) and to determine the nature of the continuing interactions between the surface environment in which we live and the deep interior. Experimental study of these processes will involve establishment of a world-class facility for materials synthesis at high pressures and ....Origin and Evolution of the Earth's Chemical Reservoirs. The scientific aims of this project are to understand the processes by which the Earth separated into its chemically-distinct layers (core, mantle, crust, atmosphere, oceans) and to determine the nature of the continuing interactions between the surface environment in which we live and the deep interior. Experimental study of these processes will involve establishment of a world-class facility for materials synthesis at high pressures and temperatures. This facility will provide the means to simulate the processes occurring within the Earth and will enable synthesis of new high density materials of technological interest.Read moreRead less
Fault-tolerant operation and scale-up of a silicon quantum computer beyond laboratory prototypes. The Centre for Quantum Computer Technology's mission is the construction of a prototype few-qubit silicon quantum processor to demonstrate the feasibility of this breakthrough technology for massively parallel computation. This application will initiate a new strategic research program within the Centre to address the key issue of interfacing laboratory with silicon CMOS microelectronics. The Hybrid ....Fault-tolerant operation and scale-up of a silicon quantum computer beyond laboratory prototypes. The Centre for Quantum Computer Technology's mission is the construction of a prototype few-qubit silicon quantum processor to demonstrate the feasibility of this breakthrough technology for massively parallel computation. This application will initiate a new strategic research program within the Centre to address the key issue of interfacing laboratory with silicon CMOS microelectronics. The Hybrid Quantum- Conventional Processor will provide calibrated gate control and readout of individual buried atom quantum bits,to run logic operations with quantum error correction. This program will require a deep understanding of physics issues to develop fault tolerant coherent control of qubit arrays for real applications.Read moreRead less
Coherent X-ray Science and Biophysics. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However, as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This program draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein ....Coherent X-ray Science and Biophysics. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However, as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This program draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less