Personalizing Antipsychotic Medicines To Improve Patient Outcomes In Schizophrenia: Development Of Decision Support Tools Using Pharmacometabolomics And Pharmacometrics
A Whole Genome Association Study For Determinants Of Clinical Outcome And Treatment Response In Chronic Hepatitis C
Funder
National Health and Medical Research Council
Funding Amount
$360,133.00
Summary
Chronic hepatitis C infection (CHC) causes liver failure, liver cancer and death. The treatment response rate is poor. Understanding of the factors that increase an individual’s risk of developing serious liver disease, or that lead to treatment failure, is limited. This project, the first of its kind, will involve screening 1600 CHC patients for genes that are associated with disease outcome and treatment response, to identify novel targets for drug and vaccine development
Novel Strategies For The Treatment Of Alcohol Dependance
Funder
National Health and Medical Research Council
Funding Amount
$290,629.00
Summary
The proposed project is designed to extend my current project and improve the treatment of alcohol dependence by addressing three barriers to successful treatment. Firstly, a novel, integrated, stepped-care treatment for alcohol dependence and comorbid anxiety or depression will be examined in a randomised controlled trial. Secondly, the relationship between sleep disturbances, relapse and treatment retention and outcomes will be characterised. Thirdly, genetic predictors to the treatment of the ....The proposed project is designed to extend my current project and improve the treatment of alcohol dependence by addressing three barriers to successful treatment. Firstly, a novel, integrated, stepped-care treatment for alcohol dependence and comorbid anxiety or depression will be examined in a randomised controlled trial. Secondly, the relationship between sleep disturbances, relapse and treatment retention and outcomes will be characterised. Thirdly, genetic predictors to the treatment of the anti-craving medications, acamprosate and naltrexone will be investigated. The first two aims will utilise subjects recruited across three sites in Sydney while the third aim will involve analyses of blood samples and clinical data from my current projectRead moreRead less
Using Next-generation Sequencing Technology To Identify Genetic Determinants Of Epilepsy And Sporadic Epilepsy Prognosis
Funder
National Health and Medical Research Council
Funding Amount
$322,282.00
Summary
Recent advances in high-throughput, next-generation, DNA sequencing allows biologists to simultaneously analyse the differences in thousands of different genes across affected and unaffected individuals. However, it produces an overwhelming amount of data and making sense of this deluge of data is a current challenge. Overcoming this challenge will enable scientific discoveries of pathogenic variants of disease, potentially providing an opportunity for targeted drug development.