Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560661
Funder
Australian Research Council
Funding Amount
$245,300.00
Summary
Particulate Characterisation for Pharmaceutical and Engineering Applications. The aim of this proposal is to establish joint facilities between the University of Sydney, Monash University and UNSW for the characterization of surface properties and particle sizes of pharmaceutical aerosols and industrial powders. Such knowledge is important for controlling aerosol production and delivery of drug particles to the lungs. This will have a significant benefit to the pharmaceutical industry and patien ....Particulate Characterisation for Pharmaceutical and Engineering Applications. The aim of this proposal is to establish joint facilities between the University of Sydney, Monash University and UNSW for the characterization of surface properties and particle sizes of pharmaceutical aerosols and industrial powders. Such knowledge is important for controlling aerosol production and delivery of drug particles to the lungs. This will have a significant benefit to the pharmaceutical industry and patients requiring aerosol treatment. Further, the proposed facilities will enhance research in complex particulate processes and modelling, functional nanomaterials, and soft sensor development, thus keeping Australia at the forefront of powder research into various high value adding particulate areas.Read moreRead less
Physico-chemical and Biopharmaceutical Investigations of Novel Drug Delivery Systems for Oral Administration of Lipophilic Drugs. The new platform technology for carrying lipophilic molecules will be applicable to many molecules currently under development by Australian Industry and will inspire novel encapsulation approaches to new and existing drugs as well as functional foods and nutraceuticals. Improved oral bioavailability of anticancer drugs will improve the quality of life of patients, re ....Physico-chemical and Biopharmaceutical Investigations of Novel Drug Delivery Systems for Oral Administration of Lipophilic Drugs. The new platform technology for carrying lipophilic molecules will be applicable to many molecules currently under development by Australian Industry and will inspire novel encapsulation approaches to new and existing drugs as well as functional foods and nutraceuticals. Improved oral bioavailability of anticancer drugs will improve the quality of life of patients, reduce health care costs and provide broader benefits to the community. The Australian biotechnology/pharmaceutical industries can share in a greater proportion of the US$50 billion market for specialised drug delivery, which is increasing by 20% annually. Australia's scientific competitiveness will be strengthened in the fields of nano-encapsulation and colloidal delivery.Read moreRead less
Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing ....Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing the need for revision surgery. Read moreRead less
Microfluidic photonic systems. Australia is set to reap commercial benefits nationally and internationally from new developments in the highly competitive domain of microtechnology. In this project, a group of Australia's leading researchers propose an innovative combination of two exciting fields of scientific research. Microfluidics is the manipulation of minute quantities of liquids in microscopic channels, while photonics is the generation, transmission, detection and analysis of light as a ....Microfluidic photonic systems. Australia is set to reap commercial benefits nationally and internationally from new developments in the highly competitive domain of microtechnology. In this project, a group of Australia's leading researchers propose an innovative combination of two exciting fields of scientific research. Microfluidics is the manipulation of minute quantities of liquids in microscopic channels, while photonics is the generation, transmission, detection and analysis of light as a means to convey, collect and process information. The marriage of these two fields promises the development of novel, high performance tunable devices for sensing, biotechnology and telecommunications.Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these so ....Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these societal needs and provide a new way to purify these important molecules. National and community benefits will accrue from this scientific innovation and from its application, which is expected to provide more efficient manufacturing opportunities for key biotechnology industries.Read moreRead less
Functional characterisation of neurons derived from embryonic stem cells and NS cells. The ability to obtain specific neurons from NS cells will revolutionise the study of nerve function, will allow the establishment of much-improved models for discovery of new drugs, and will define how enriched populations of neural cells can be obtained for applications in treatment of neurodegenerative diseases. The project will provide vital data for the emerging biotechnology industry associated will appl ....Functional characterisation of neurons derived from embryonic stem cells and NS cells. The ability to obtain specific neurons from NS cells will revolutionise the study of nerve function, will allow the establishment of much-improved models for discovery of new drugs, and will define how enriched populations of neural cells can be obtained for applications in treatment of neurodegenerative diseases. The project will provide vital data for the emerging biotechnology industry associated will applications of stem cell biology, and will stimulate clinical researchers to investigate the therapeutic potential of cell derived from NS cells.Read moreRead less
Understanding, prediction and control of polymorphism in pharmaceuticals. The proposed research will lead, through a better understanding of polymorphism, to more efficient production of pharmaceuticals and will enhance the establishment and protection of patents. The work will have flow-on in other areas such as the manufacture of pigments, dyes and explosives. The project uses methodology for the elucidation of local structure and function at the atomic to nanoscale level in which Australia is ....Understanding, prediction and control of polymorphism in pharmaceuticals. The proposed research will lead, through a better understanding of polymorphism, to more efficient production of pharmaceuticals and will enhance the establishment and protection of patents. The work will have flow-on in other areas such as the manufacture of pigments, dyes and explosives. The project uses methodology for the elucidation of local structure and function at the atomic to nanoscale level in which Australia is a world leader. The project will further enhance our standing in this field and will provide excellent research training opportunities in areas particularly pertinent to future exploitation of the Australian Synchrotron and the new Research Reactor OPAL, which open in 2007. Read moreRead less
Novel Technologies for the Purification of Recombinant Proteins. Availability of enabling technologies for the large-scale purification of recombinant proteins is an essential requirement of the biotechnology industry. This project aims to integrate two concepts in molecular biorecognition. New modalities of immobilised metal ion affinity chromatography will be linked with the selection of new types of peptide affinity handles that can be inserted by genetic engineering methods into proteins pro ....Novel Technologies for the Purification of Recombinant Proteins. Availability of enabling technologies for the large-scale purification of recombinant proteins is an essential requirement of the biotechnology industry. This project aims to integrate two concepts in molecular biorecognition. New modalities of immobilised metal ion affinity chromatography will be linked with the selection of new types of peptide affinity handles that can be inserted by genetic engineering methods into proteins produced by biotechnological procedures. The approach followed then allows these handles to be removed following isolation of the target protein. This project could thus lead to a considerable advance in the manufacture of recombinant proteins intended for human therapy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238094
Funder
Australian Research Council
Funding Amount
$197,000.00
Summary
Fine and Ultrafine Particle - Characterisation and Research Facility. The proposed grant aims to establish an integrated facility for characterising and researching fine and ultrafine particles. It will serve various research groups of three collaborating universities. Current facilities are limited to characterisation of liquid-borne particles down to 10 nm size. To extend the groups research interests into aerosols and nanoparticles the facilities requested in this grant are essential. Equipme ....Fine and Ultrafine Particle - Characterisation and Research Facility. The proposed grant aims to establish an integrated facility for characterising and researching fine and ultrafine particles. It will serve various research groups of three collaborating universities. Current facilities are limited to characterisation of liquid-borne particles down to 10 nm size. To extend the groups research interests into aerosols and nanoparticles the facilities requested in this grant are essential. Equipment critical for research into catalytic processes is also requested. Integration of the groups will create a force that institutions and industries,nation-wide, can turn to when the need for competent analytical and research solutions for particles and catalysis arises.Read moreRead less