Nanoassembling agrochemicals - a new paradigm in delivery for enviro-friendly crop treatment. This project will determine innovative new forms of preparing agrochemicals that will deliver significant environmental and economical benefits to Australia and the Australian-based agrochemical industry. Reduced chemical and water usage will contribute to an environmentally sustainable Australia, while more economical farming will benefit rural Australia.
Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leader ....Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leaders in their respective fields to address a highly multidisciplinary are of research and will provide excellent training for the PhDs and post doctoral research associates, enabling them to work in and contribute to the development of new biomedical industries in Australia.Read moreRead less
Highly ordered and tunable extracellular DNA micro- and nanopatterns for investigating the attachment mechanisms of pseudomonas aeruginosa to surfaces. Preventing infectious bacteria from colonising artificial surfaces is a major scientific challenge. New engineered surfaces will be designed to better understand how the important pathogen Pseudomonas aeruginosa sticks to surfaces, facilitating new ways of reducing infections acquired from the surface of, for example, medical devices.
Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells. The need for potent low-cost drugs is ever increasing, yet effective ways to screen for new drugs remain elusive. A spectroscopic approach to screening drugs in living cells would seem a logical alternative to chemically based and morphological methods that are the status quo. In this context we are developing methodology to analyse molecular target sites in single living cells for ....Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells. The need for potent low-cost drugs is ever increasing, yet effective ways to screen for new drugs remain elusive. A spectroscopic approach to screening drugs in living cells would seem a logical alternative to chemically based and morphological methods that are the status quo. In this context we are developing methodology to analyse molecular target sites in single living cells for two of the most devastating diseases to afflict human kind, namely malaria and cancer. New ways of rapidly screening drugs in living cells prior to clinical trials will save an enormous amount of time, money and ultimately lives.Read moreRead less
Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal w ....Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal will receive international recognition and will encourage more research in this field, attracting international funding, and create new research opportunities. Read moreRead less
Artificial Proteins for the Control of Colloid and Surface Properties. A large amount of Australia's wealth arises from mining and the processing of small (colloidal) particles. This project will develop new coatings for particles, which will allow better control of the properties of particle suspensions. Control of surface properties is also important in the preparation of ceramics and in the preparation of implants and biosensors. The development of new coatings will also offer opportunitie ....Artificial Proteins for the Control of Colloid and Surface Properties. A large amount of Australia's wealth arises from mining and the processing of small (colloidal) particles. This project will develop new coatings for particles, which will allow better control of the properties of particle suspensions. Control of surface properties is also important in the preparation of ceramics and in the preparation of implants and biosensors. The development of new coatings will also offer opportunities for improved performance in these areas.
Many existing coating technologies rely on procedures using organic solvents, which are hazardous to human health and the environment. The proposed research will develop coatings that are made and used in solutions of water only, thereby minimizing pollution production.
Read moreRead less
Novel Nanomaterials for Photocatalytic Water Purification - Science and Application. Water is rapidly becoming Australia's most critical natural resource, and there is an urgent need to re-use and recycle water from domestic use (graywater) and industry, as well as utilisation of larger scale harvesting of rainwater. The outcome of this project will be a technology which can remove organic material (biological and non-biological) from water, enabling a greater range of uses of wastewater. This ....Novel Nanomaterials for Photocatalytic Water Purification - Science and Application. Water is rapidly becoming Australia's most critical natural resource, and there is an urgent need to re-use and recycle water from domestic use (graywater) and industry, as well as utilisation of larger scale harvesting of rainwater. The outcome of this project will be a technology which can remove organic material (biological and non-biological) from water, enabling a greater range of uses of wastewater. This technology will play a significant role in delivering future water security, and developing new industries involved in manufacture and export of water treatment technologies. This project directly addresses the National Priority Research area of water, and international priorities involving greater re-use and recycling of water.Read moreRead less
Reduced water usage in the Australian pulp and paper industry through novel process chemistry. Norske Skog Paper Mill operates two paper mills on major rivers in Australia. For these mills to reduce water consumption greater recycling of the process water is needed which results in a build-up of detrimental substances that will affect paper machine performance and efficiency. The knowledge gained from this project will help the paper mills to find strategies to control the build-up of the detr ....Reduced water usage in the Australian pulp and paper industry through novel process chemistry. Norske Skog Paper Mill operates two paper mills on major rivers in Australia. For these mills to reduce water consumption greater recycling of the process water is needed which results in a build-up of detrimental substances that will affect paper machine performance and efficiency. The knowledge gained from this project will help the paper mills to find strategies to control the build-up of the detrimental material and deal with it in such a way that the process water can be recycled and the paper mills can reduce water consumption.Read moreRead less
Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth fac ....Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth factors, to permit the growth and differentiation of mammalian stem cells. This project will result in biomaterials for the treatment of blinding diseases of the eye. Implanted into the limbus, bioimplants may ameliorate some common corneal diseases.Read moreRead less
The role of fat crystal wettability in altering dairy emulsion properties. The role of fat crystal wettability in altering dairy emulsion properties. This project aims to control fat crystal wettability, to create tailored dairy products with desirable stability, shelf-life and texture. Fat crystals are an essential component of dairy emulsions (fat droplets dispersed in dairy/milk serum) and control product processing, shelf life and texture. Their structuring role involves partial coalescence: ....The role of fat crystal wettability in altering dairy emulsion properties. The role of fat crystal wettability in altering dairy emulsion properties. This project aims to control fat crystal wettability, to create tailored dairy products with desirable stability, shelf-life and texture. Fat crystals are an essential component of dairy emulsions (fat droplets dispersed in dairy/milk serum) and control product processing, shelf life and texture. Their structuring role involves partial coalescence: the formation of complicated network structures of fat droplets. Unless fat crystals are partially wetted by water, they will not be present at the fat droplet interface, and partial coalescence will not occur. Expected outcomes are new dairy products with optimum stability and texture.Read moreRead less