A link between periodontal disease, inflammation of the gums, and cardiovascular disease has been suggested in recent studies, however the evidence remains uncertain. Supporting the link are data that inflammation predisposes to atherosclerosis and heart attacks. Patients in the PERICAR study will have blood tests before and after periodontal treatment so that researchers can study whether treatment reduces factors in the blood that have previously been shown to indicate the risk of cardiovascul ....A link between periodontal disease, inflammation of the gums, and cardiovascular disease has been suggested in recent studies, however the evidence remains uncertain. Supporting the link are data that inflammation predisposes to atherosclerosis and heart attacks. Patients in the PERICAR study will have blood tests before and after periodontal treatment so that researchers can study whether treatment reduces factors in the blood that have previously been shown to indicate the risk of cardiovascular disease. This study will provide further clues to this potentially very important and treatable relationship.Read moreRead less
Evaluation Of Tissue Engineered Decellularised Biphasic Constructs For Periodontal Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$578,031.00
Summary
This project aims to regenerate the tissues lost as a result of gum disease. This will be done using scaffolds that replicate the complex structure of periodontal tissues.The scaffolds will be loaded with cells and allowed to mature before the cellular component is removed. The resultant construct is then inserted back into periodontal defects where it will be repopulated by host cells. This approach has the potential to be developed into an off-the-shelf clinical treatment.
Dental diseases affecting the gums (periodontal diseases) are extremely prevalent in our society. The effects of periodontal disease can be particularly severe as loss of support for the teeth leads to loose teeth and severely compromised chewing function. If left untreated, the associated loss of function may necessitate extraction of the teeth. We have recently identified cells residing in the periodontal ligament which may be adult stem cells. This project will further characterize these cell ....Dental diseases affecting the gums (periodontal diseases) are extremely prevalent in our society. The effects of periodontal disease can be particularly severe as loss of support for the teeth leads to loose teeth and severely compromised chewing function. If left untreated, the associated loss of function may necessitate extraction of the teeth. We have recently identified cells residing in the periodontal ligament which may be adult stem cells. This project will further characterize these cells and explore whether they can be used to restore periodontal tissues damaged by periodontal disease.Read moreRead less
Periodontal disease is an inflammatory disorder leading to tooth loosening and, if untreated, tooth loss. Once bone destruction has occurred around teeth the treatment outcomes are severely compromised and are mainly focussed towards slowing the process of destruction rather than repairing the damage. Over the last decade, treatment of advanced periodontal disease has focussed on ways in which the damaged tissues may be regenerated. We now have gained considerable insight into the molecular and ....Periodontal disease is an inflammatory disorder leading to tooth loosening and, if untreated, tooth loss. Once bone destruction has occurred around teeth the treatment outcomes are severely compromised and are mainly focussed towards slowing the process of destruction rather than repairing the damage. Over the last decade, treatment of advanced periodontal disease has focussed on ways in which the damaged tissues may be regenerated. We now have gained considerable insight into the molecular and cellular events associated with periodontal regeneration. Despite efforts to induce regeneration through the selective use of growth and differentiation factors it is becoming obvious that the most significant factor in successful clinical outcomes is the recruitment of special cells to the site of damage which have the potential to repair tissue damage. Thus, we intend to engineer different types of periodontal matrices in the laboratory and then transplant these newly formed tissues into sites affected by periodontal disease in an attempt to repair the damage caused by the disease process.Read moreRead less
Periodontal Mesenchymal Stem Cells For Periodontal Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$358,000.00
Summary
Dental diseases affecting the gums (periodontal disease) are extremely prevalent in our society. The effects of periodontal disease can be particularly severe as loss of support for the teeth leads to loose teeth and severely compromised masticatory function. If left untreated, the associated pain and loss of function may necessitate extraction of the teeth. We have recently identified cells residing in the periodontal ligament which may be adult stem cells. This project will further characteriz ....Dental diseases affecting the gums (periodontal disease) are extremely prevalent in our society. The effects of periodontal disease can be particularly severe as loss of support for the teeth leads to loose teeth and severely compromised masticatory function. If left untreated, the associated pain and loss of function may necessitate extraction of the teeth. We have recently identified cells residing in the periodontal ligament which may be adult stem cells. This project will further characterize these cells and explore whether they can be used to restore periodontal tissues damaged by periodontal disease.Read moreRead less
Relationship Between Periodontal Disease And Rheumatoid Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$520,657.00
Summary
Periodontal (gum) disease and rheumatoid arthritis are two of the most common chronic inflammatory diseases affecting humans. These two diseases have remarkably similar patterns of tissue destruction. It is possible that individuals with chronic periodontitis may prime or predispose individuals prone to developing rheumatoid arthritis. Treatment of periodontal disease may help reduce the severity of rheumatoid arthritis.