Understanding How Toxins Interact With Lipid Membranes And Ion Channels
Funder
National Health and Medical Research Council
Funding Amount
$598,220.00
Summary
Chronic pain affects one in five Australians and current treatments have limited effectiveness, with only about one third of patients getting meaningful, pain relief. The aim of the current project is to create alternative treatments for pain that can potentially lead to the reduced suffering and improvement of life quality of many Australians. To achieve this aim we propose to study how spider toxins interact with cells and deactivate sensor targets responsible for chronic pain.
Innovations in peptide-based drug design. This project will aim to develop new types of drugs that fill a gap between existing small molecule drugs, which are relatively inexpensive and stable, but often have side-effects, and biologics which are very expensive and require injection. Our new generation of peptide-based drugs promise to be applicable to diseases that are not treatable by current drugs.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100218
Funder
Australian Research Council
Funding Amount
$840,000.00
Summary
A Nuclear Magnetic Resonance Facility for Modern Molecular Analysis. A nuclear magnetic resonance facility for modern molecular analysis:
This project aims to network a new 500 MHz nuclear magnetic resonance (NMR) spectrometer and new consoles for existing instruments with an automated sample changer for a 600 MHz NMR spectrometer. This designed to increase the capacity of Queensland-based researchers to undertake state-of-the-art studies in chemistry, drug design, and materials science. The ne ....A Nuclear Magnetic Resonance Facility for Modern Molecular Analysis. A nuclear magnetic resonance facility for modern molecular analysis:
This project aims to network a new 500 MHz nuclear magnetic resonance (NMR) spectrometer and new consoles for existing instruments with an automated sample changer for a 600 MHz NMR spectrometer. This designed to increase the capacity of Queensland-based researchers to undertake state-of-the-art studies in chemistry, drug design, and materials science. The new knowledge from these studies may lead to the development of new drugs, new crop protection agents and new photovoltaic materials. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120103152
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Development of next generation drugs against Helicobacter pylori. Gastric cancer is the second leading cause of cancer-related death in the world and infection by Helicobacter pylori bacteria is the main cause of this disease. The aim of this project is to develop new approaches to treat Helicobacter pylori infection that will give superior results and lower side effects than available therapies.
Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this pr ....Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this project will tackle. This proposal aims to create a technology to stabilise and deliver active gene material to target cells. The gene delivery tool developed in this project will advance biological research greatly with many potential future applications.Read moreRead less
New methods for the chemical synthesis of a library of glycopeptide-based tri-component cancer vaccines. A novel method for the synthesis of tumour-associated glycopeptides will be developed in this research as well as the preparation of a library of glycopeptide-based cancer vaccines. These vaccines will be tested in immunological studies with a view to elucidating new immune-based therapies for the treatment of cancer.
Discovery Early Career Researcher Award - Grant ID: DE140101632
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Development of Innovative Chemical Tools for Studying Glycosyltransferases . This project aims to develop chemical probes capable of selectively binding and inhibiting two classes of carbohydrate processing enzymes known as O-linked beta-N-acetylglucosamine transferase and sialyltransferases. These enzymes are overexpressed in various cancers and play critical roles in cancer progression. Probes will be developed to analyse the activities of these enzymes in cancer cells.
Rational Development Of Novel Analgesics For The Treatment Of Chronic Pain
Funder
National Health and Medical Research Council
Funding Amount
$595,945.00
Summary
Chronic pain is a major global health problem that currently affects over three million Australians. There are few drugs available for treatment of chronic pain and most have significant side-effects. Individuals lacking a particular type of ion channel known as Nav1.7 are completely insensitive to pain, but are otherwise normal. Block of this channel therefore appears to be an ideal avenue for pain relief. This project aims to produce selective Nav1.7 blockers that can be used as analgesics for ....Chronic pain is a major global health problem that currently affects over three million Australians. There are few drugs available for treatment of chronic pain and most have significant side-effects. Individuals lacking a particular type of ion channel known as Nav1.7 are completely insensitive to pain, but are otherwise normal. Block of this channel therefore appears to be an ideal avenue for pain relief. This project aims to produce selective Nav1.7 blockers that can be used as analgesics for treating chronic pain.Read moreRead less
Development of effective peptide-based drugs. There is huge interest in the development of bioactive peptides and proteins for the treatment of a wide range of diseases. The aim of this research project is to develop potent and effective peptide-based drugs that are able to resist the body's natural degradation pathways so that they can reach their biological target and act as effective drugs.