Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Time dependent stratified flows in a differentially heated cavity under realistic conditions. Flows driven by the application of a horizontal temperature gradient has applications in nature and engineering. Although much progress has been made in the analysis of the case of a sudden application of temperature differences to the vertical walls of a container with insulating horizontal walls containing an isothermal fluid, the reality is that neither the insulated walls nor the initially isotherma ....Time dependent stratified flows in a differentially heated cavity under realistic conditions. Flows driven by the application of a horizontal temperature gradient has applications in nature and engineering. Although much progress has been made in the analysis of the case of a sudden application of temperature differences to the vertical walls of a container with insulating horizontal walls containing an isothermal fluid, the reality is that neither the insulated walls nor the initially isothermal fluid can be achieved. This project will, by analytical, numerical and experimental methods, make a preliminary investigation of the influence of conducting horizontal walls and an initially stratified fluid.Read moreRead less
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Developing Salient Messages For Indigenous Tobacco Control In Rural Aboriginal Smokers
Funder
National Health and Medical Research Council
Funding Amount
$117,331.00
Summary
I am a General Practitioner with a keen interest in smoking cessation particularly for Aboriginal people, who have a high rate of smoking. Media messages are not to date being completely effective in this group, so I am investigating how to make more relevant and persuasive messages to support Indigenous smokers and their families (importantly pregnant smokers) to become smoke-free and encourage them to use effective treatments to do so.
Why Is The Bone Marrow A “hot-spot” For Myeloma Plasma Cell Metastasis: Are There Gremlins In The System?
Funder
National Health and Medical Research Council
Funding Amount
$651,979.00
Summary
Most cancer patients die because their cancer spreads from a primary site to other tissues in the body. Once escaping the primary site, 70% of all tumours will spread to bone. This raises the question, why is bone a preferred destination for cancer cells? We provide evidence that Gremlin1, made by non-cancer cells within bone, is a key protein that supports cancer growth. This study will examine whether inhibiting Gremlin1 is a potential therapy to inhibit cancer spreading to bone.
Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result ....Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result in an increase of the overall capacity and performance of engineering systems. This will contribute significantly to reductions in power consumption and improvements in productivity and work environment, leading ultimately to reductions in greenhouse gas emissions and to economic benefits.Read moreRead less
Design tools for optimising data centre layout to minimise energy usage. Data centres are major consumers of energy worldwide, mainly through the need to cool the equipment. It has become imperative to develop the science for reducing this consumption. Rising computing demand, increasing power density, and increasing infrastructure and energy costs are major issue for data centres around the world. Our research will provide a powerful alternative to conventional thermal management techniques for ....Design tools for optimising data centre layout to minimise energy usage. Data centres are major consumers of energy worldwide, mainly through the need to cool the equipment. It has become imperative to develop the science for reducing this consumption. Rising computing demand, increasing power density, and increasing infrastructure and energy costs are major issue for data centres around the world. Our research will provide a powerful alternative to conventional thermal management techniques for cooling high-density heat loads in mixed-density environments. We will address the key issue of energy minimisation through a detailed flow analyses by the use of numerical simulations and optimisation algorithms.Read moreRead less
Modelling of unsteady natural convection in a reservoir sidearm. Horizontal exchange flows induced by daytime heating and night-time cooling through water surface play an important role in the transport of water properties in the shoreline regions of reservoirs. This project is aimed at exploring the driving mechanisms of these flows through a closely linked experimental, numerical and analytical research program. At the completion of this project, significant advance in experimental methodology ....Modelling of unsteady natural convection in a reservoir sidearm. Horizontal exchange flows induced by daytime heating and night-time cooling through water surface play an important role in the transport of water properties in the shoreline regions of reservoirs. This project is aimed at exploring the driving mechanisms of these flows through a closely linked experimental, numerical and analytical research program. At the completion of this project, significant advance in experimental methodology will be achieved, and reliable experimental and theoretical data will be available that can be used to estimate the heat and mass transfer in the coastal regions which is important for water quality management and environmental planning.Read moreRead less
Natural convection induced exchange flows between near shore and central regions of reservoirs. Inland discharges into reservoirs often carry rich nutrients, pollutants and biological species into the coastal regions, which are redistributed across the central regions of reservoirs through dynamical mixing processes. One of the important mixing processes is the horizontal exchange flow between the near shore and central regions induced by diurnal heating and cooling through the water surface, wh ....Natural convection induced exchange flows between near shore and central regions of reservoirs. Inland discharges into reservoirs often carry rich nutrients, pollutants and biological species into the coastal regions, which are redistributed across the central regions of reservoirs through dynamical mixing processes. One of the important mixing processes is the horizontal exchange flow between the near shore and central regions induced by diurnal heating and cooling through the water surface, which is classified as a natural convection process. This process will be investigated in this project through a closely linked analytical, experimental and numerical research program. The output from this research will have direct application in water quality management and environmental planning.Read moreRead less