INTroducing A Care Bundle To Prevent Pressure Injury (the INTACT Trial)
Funder
National Health and Medical Research Council
Funding Amount
$1,093,250.00
Summary
In Australia, hospital acquired pressure injuries (i.e. bedsores) range from 7.4% – 17.4%. A care bundle is a structured group of interventions associated with improved patient outcomes. The aim of this 3-year cluster randomised controlled trial is to provide rigorous evidence regarding the effect of a patient centred pressure injury prevention care bundle on the development of pressure injuries in patients at risk of developing a hospital acquired pressure injury.
The Implementation Of MinimAlly INvasivE Hysterectomy (IMAGINE) Trial
Funder
National Health and Medical Research Council
Funding Amount
$656,854.00
Summary
Hysterectomy is the most common surgical [procedure among Australian women. Too many women still receive an open abdominal surgery, because too few Australian obstetricians and gynaecologists practice laparoscopic hysterectomy. This partnership will develop a model to systematically train practicing surgeons in advanced laparoscopic techniques. If successful, the model can be rolled out state and nationwide and also adapted for teaching future innovations in surgery.
Improving Oesophageal Adenocarcinoma Outcomes Through Understanding Genomics And Treatment Toxicity.
Funder
National Health and Medical Research Council
Funding Amount
$1,013,282.00
Summary
Oesophageal adenocarcinoma is an aggressive cancer, as most patients will not survive for more than 5 years. Therefore we need to find better ways to treat patients. In this study we will identify the DNA mutations in oesophageal cancers that were part of clinical trial. The data allow us to determine why some tumours responded well to therapy, and why some patients had serious side effects to the treatment. The results will help inform on selection of therapy for future patients.
Improving Nurse-administered Sedation Practice In The Cardiac Catheterisation Laboratory
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
This research will provide evidence to inform nursing management of the potentially life-threatening complications that are associated with the administration of sedation in the cardiac catheterisation laboratory. Three studies will be conducted: an investigation of the prevalence and risk factors of hypothermia after sedation; a randomised controlled trial of active warming to prevent hypothermia; and a study to determine whether audit and feedback improves patient safety during sedation.
Maximising pineapple production for Australian farmers using genome editing. This project addresses the single biggest issue affecting the viability of pineapple farming in Australia and internationally: premature flowering leading to supply collapse. We aim to develop CRISPR technology to breed new pineapple varieties using non-GM approaches. Expected outcomes include the production of pineapples with resistance to premature flowering, as well as the technologies to deliver additional improveme ....Maximising pineapple production for Australian farmers using genome editing. This project addresses the single biggest issue affecting the viability of pineapple farming in Australia and internationally: premature flowering leading to supply collapse. We aim to develop CRISPR technology to breed new pineapple varieties using non-GM approaches. Expected outcomes include the production of pineapples with resistance to premature flowering, as well as the technologies to deliver additional improvements in the future. The new varieties will benefit farmers through increased production, maximising supply capability for a rapidly growing internal demand. This will benefit Australian pineapple producers through higher profitability in existing markets, as well as enabling expansion into international and future markets.Read moreRead less
Improving Quality Of Life In High-risk Cancer Populations: A Randomised Trial Of A Structured Intervention For Head And Neck Cancer Survivors
Funder
National Health and Medical Research Council
Funding Amount
$493,220.00
Summary
Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional conc ....Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional concerns.Read moreRead less
Harnessing Information Technology To Improve Self-management Behaviours And Health Outcome In People With Heart Failure: A Smarthome Ecosystem Living Lab Study
Funder
National Health and Medical Research Council
Funding Amount
$1,120,226.00
Summary
The burden of heart failure in Australia is substantial. Management of heart failure is complex and requires self-management of symptoms and behaviour change, which requires ongoing education and support to achieve. Current approaches for supporting self-management do not meet the needs of people with heart failure or the healthcare system. This Australian first project aims to co-design an intelligent smart home ecosystem (Smart Heart) to support the management for people with heart failure.
Manipulation of carbon partitioning to enhance the value of sugarcane. Manipulation of carbon partitioning to enhance the value of sugarcane. This project aims to develop enhanced varieties of sugarcane, a highly efficient crop for capturing carbon in plant biomass. This project will use genomic and metabolomic tools to investigate the biochemical and molecular genetic control of carbon partitioning into the major components of sugarcane biomass; identify key genetic controls of sucrose, cellulo ....Manipulation of carbon partitioning to enhance the value of sugarcane. Manipulation of carbon partitioning to enhance the value of sugarcane. This project aims to develop enhanced varieties of sugarcane, a highly efficient crop for capturing carbon in plant biomass. This project will use genomic and metabolomic tools to investigate the biochemical and molecular genetic control of carbon partitioning into the major components of sugarcane biomass; identify key genetic controls of sucrose, cellulose, hemicellulose and lignin biosynthesis; and establish strategies for genetic selection of sugarcane genotypes with desirable biomass components. Anticipated outcomes are an optimised industrial sugarcane crops with higher sugar content and other biomass components designed for high value end uses such as bio-energy or bio-material production.Read moreRead less
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
A Multi-centre RCT To Prevent Secondary Falls In Older People Presenting To The Emergency Department With A Fall
Funder
National Health and Medical Research Council
Funding Amount
$1,534,471.00
Summary
Falls are a leading cause for presentation to Emergency Departments (EDs) by older patients. More than 50% who present to ED with a fall injury have fallen in the previous year. RESPOND is an innovative post-ED discharge program designed to reduce secondary falls in older people. RESPOND extends current falls prevention research and practice by incorporating patient-centred education with behaviour change strategies proven to be effective in the secondary prevention of cardiovascular events.