Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Skin penetration of nanoparticles promoted by particle design, formulation and application method. This project seeks to better define the determinants of nanoparticle skin penetration and subsequent disposition in the body. The data would be used to guide minimal skin penetration of 'undesirable' nanoparticles and the properties required of 'safe' nanoparticles to enable effective human skin delivery in cosmetic and dermatological products.
Nanoscale Particle Control by Rigid Biomineralised Surfaces. The proposed research will increase understanding of the strategies diatoms use to sort particles. Our hypothesis is that in the process of understanding how these diatom surfaces control particles, blueprints for microfluidic devices will be identified. The appeal of diatoms goes beyond consideration of the geometrical patterning on their surfaces, because their frustules (the diatomic shells) are made primarily out of silica, a mater ....Nanoscale Particle Control by Rigid Biomineralised Surfaces. The proposed research will increase understanding of the strategies diatoms use to sort particles. Our hypothesis is that in the process of understanding how these diatom surfaces control particles, blueprints for microfluidic devices will be identified. The appeal of diatoms goes beyond consideration of the geometrical patterning on their surfaces, because their frustules (the diatomic shells) are made primarily out of silica, a material also used in nanofabrication. We expect that some of the strategies and patterns used by cells will be able to be directly transferred to microfluidics, and bypass years of empirical development in nanofabrication and lab-on-a-chip devices.Read moreRead less
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100003
Funder
Australian Research Council
Funding Amount
$2,611,346.00
Summary
ARC Research Hub for Graphene Enabled Industry Transformation. ARC Research Hub for Graphene Enabled Industry Transformation. This research hub aims to provide the advanced materials industry with innovative solutions to tackle critical and complex challenges of national significance. The hub intends to leverage substantial existing and new investments to overcome fundamental scientific barriers and develop fit-for-purpose graphene products with and for its partners. Advanced materials, particul ....ARC Research Hub for Graphene Enabled Industry Transformation. ARC Research Hub for Graphene Enabled Industry Transformation. This research hub aims to provide the advanced materials industry with innovative solutions to tackle critical and complex challenges of national significance. The hub intends to leverage substantial existing and new investments to overcome fundamental scientific barriers and develop fit-for-purpose graphene products with and for its partners. Advanced materials, particularly graphene, are now considered promising for maintaining competitive advantages for industrial transformational progress; and advanced industries to drive prosperity where innovation underpins business to thrive globally. The anticipated impacts are long-term economic prosperity and growth.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100025
Funder
Australian Research Council
Funding Amount
$4,379,165.00
Summary
ARC Research Hub for Advanced Manufacturing with 2D Materials (AM2D). Australia holds large resources of critical 2D minerals – key enablers of several existing and emerging technologies in Energy Storage, Purification and Printed Electronics. The AM2D hub aims to provide a sophisticated environment for researchers and an industrial translation platform for manufacturers; a hub where leading academics, bright students, and industry partners come together to learn, apply, collaborate, innovate, a ....ARC Research Hub for Advanced Manufacturing with 2D Materials (AM2D). Australia holds large resources of critical 2D minerals – key enablers of several existing and emerging technologies in Energy Storage, Purification and Printed Electronics. The AM2D hub aims to provide a sophisticated environment for researchers and an industrial translation platform for manufacturers; a hub where leading academics, bright students, and industry partners come together to learn, apply, collaborate, innovate, and deliver industry transformation in advanced manufacturing. Anticipated outcomes include the transformation of newly discovered materials into globally traded, high-value 2D products, enabling Australian industries to capture more wealth and jobs from this large and growing market.
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Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological method ....Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological methods. This work is expected to determine how nanomaterials’ attributes direct pathways for liver cell disposal and describe nanomaterial–liver interactions at the cellular level, information crucial in enabling safer nanomaterials for use in products such as drug formulations, sunscreens and cosmetics.Read moreRead less