Socio-economic determinants and health inequalities over the life course: Australian and English comparisons. Our multidisciplinary investigation will yield Australia's first major body of knowledge on the socio-economic determinants of health and health inequalities over the life course. It will point the way towards policies that can promote health and reduce the health inequalities experienced by disadvantaged individuals and families. It will indicate how improving the health of ageing Aus ....Socio-economic determinants and health inequalities over the life course: Australian and English comparisons. Our multidisciplinary investigation will yield Australia's first major body of knowledge on the socio-economic determinants of health and health inequalities over the life course. It will point the way towards policies that can promote health and reduce the health inequalities experienced by disadvantaged individuals and families. It will indicate how improving the health of ageing Australian men and women can increase productivity and reduce needs for health services during the rapid population ageing that lies ahead. Comparisons with England will inform policy choices. We will train researchers who will play a future role in building Australia's evidence base to guide constructive policies to 2020 and beyond.Read moreRead less
Identification of genes regulating breast cancer progression and metastasis. Breast cancer is the most common cause of cancer-related death in women in Australia. Although the treatments have improved over the last thirty years, many women still die from relapse of the disease. Our goal is to identify genes involved in the regulation of breast cancer progression and metastasis. This may lead to the discovery of druggable molecules for better targeted therapies for patients.
A prospective study of the mental health of grandparents providing part-time child care for their preschool age grandchildren. This project addresses national research priorities and will identify the characteristics of a high-risk subgroup of Australian grandparents for whom the childcare burden has a deleterious impact on health and well being. Results will enable development of improved approaches to education and awareness in health professionals and the lay community about this subgroup, fa ....A prospective study of the mental health of grandparents providing part-time child care for their preschool age grandchildren. This project addresses national research priorities and will identify the characteristics of a high-risk subgroup of Australian grandparents for whom the childcare burden has a deleterious impact on health and well being. Results will enable development of improved approaches to education and awareness in health professionals and the lay community about this subgroup, facilitating early identification and intervention. The study will provide evidence-based guidance to policy makers about the most appropriate support services for grandparents involved in high levels of childcare, reducing their level of stress and improving the quality of the childcare they provide.
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Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and pro ....Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and provide more informed advice to the public on the necessity of avoiding exposure to air pollutants. These two outcomes are particularly important given Australia's ageing population and the fact that the elderly are among those most susceptible to harm from air pollution exposure.Read moreRead less
Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be rea ....Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be reactivated in these diseases for recovery of function. This project seeks to understand normal development of the brain and in doing so it will expose novel targets for therapy in the aged. Read moreRead less
The efficacy of a physical activity intervention in the management of psychological and physical symptoms among breast and prostate cancer patients. The vastly improved survival rates for breast and prostate cancer in recent years has resulted in an ever-increasing number of people living with a history of cancer. Treatment for cancer is often associated with negative side effects like fatigue, depression and sleep disturbance, and an overall impaired quality of life.
This project will assess ....The efficacy of a physical activity intervention in the management of psychological and physical symptoms among breast and prostate cancer patients. The vastly improved survival rates for breast and prostate cancer in recent years has resulted in an ever-increasing number of people living with a history of cancer. Treatment for cancer is often associated with negative side effects like fatigue, depression and sleep disturbance, and an overall impaired quality of life.
This project will assess the effectiveness of a physical activity program in alleviating these symptoms of treatment. The program will include regular walking and gentle resistance strength training.
The outcomes from the project will advance research by shedding light on which symptoms are most helped by physical activity, and how much activity is needed to gain these benefits.
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Travellers visiting friends and relatives: new approaches to understanding and reducing infectious disease risks. Travel is the single most important factor in the spread of infections globally and travellers who visit friends and relatives in their country of birth are at increased risk of infections. This project will provide necessary evidence to guide an effective response to reducing travel-associated infectious disease in this target at-risk group.
Healthy and working life expectancies in an ageing Australia. This project aims to identify social circumstances that optimise healthy and working life years in Australia. The project draws on international multidisciplinary expertise to critically evaluate social variation and inequalities in the years older adults live in good health and are engaged in work. Expected outcomes include the generation of new policy-relevant knowledge on older workers, active retirement, and healthy ageing which w ....Healthy and working life expectancies in an ageing Australia. This project aims to identify social circumstances that optimise healthy and working life years in Australia. The project draws on international multidisciplinary expertise to critically evaluate social variation and inequalities in the years older adults live in good health and are engaged in work. Expected outcomes include the generation of new policy-relevant knowledge on older workers, active retirement, and healthy ageing which will advance the field of life course epidemiology and inform the debate about Australia’s future ageing. This project should provide benefits for individual wellbeing, and provide evidence that can inform long-term public policy on health, work, welfare, and retirement.Read moreRead less
FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of grow ....FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of growing cell and tissue in quantities suitable for implantation or use in other therapeutic applications that are currently deemed impossible.Read moreRead less
Statistical Inference for Probability-Linked Longitudinal Data. The Strategic Roadmap for the Australian Government's National Collaborative Research Infrastructure Strategy states that analysis of linked data, and particularly linked longitudinal data, has the potential to revolutionise Australian public health research. Similar benefits should flow from analysis of linked datasets in other areas, e.g. the Statistical Longitudinal Census Dataset that the Australian Bureau of Statistics intends ....Statistical Inference for Probability-Linked Longitudinal Data. The Strategic Roadmap for the Australian Government's National Collaborative Research Infrastructure Strategy states that analysis of linked data, and particularly linked longitudinal data, has the potential to revolutionise Australian public health research. Similar benefits should flow from analysis of linked datasets in other areas, e.g. the Statistical Longitudinal Census Dataset that the Australian Bureau of Statistics intends to create by linking individual records across censuses. These benefits will be maximised by controlling the impact of linkage error when analysing these datasets. This proposal will develop the statistical theory and related methodology to solve this problem in a statistically efficient manner.Read moreRead less