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Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensi ....Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensitive, selective, fast and compact.Read moreRead less
Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise ....Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise to develop into new industries for Australia as well as to explore rich science opportunities at the boundaries of these disciplines.Read moreRead less
Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards be ....Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards better understanding of pathogen communication. Improved understanding of pathogen interactions should facilitate the development of novel anti-adhesives as therapeutics. Our project will train young scientists in a new integrated approach to biology.Read moreRead less
Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obe ....Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obesity, immunity, fertility, neurological function and cancer. In the plant sphere, the outcomes will shed new light on plant functions related to plant energy metabolism, vitamin biosynthesis drought tolerance and water use by crops. The research will benefit both human health and agricultural food production and quality.Read moreRead less
Establishing the reference frame using astronomical and space-geodetic observations. Australia is increasingly dependent on spatial positioning and spatial data, yet mostly relies upon international agencies and research organisations to provide regular updates of coordinates and reference frame definition used on Earth. Improving the accuracy of the reference frame definition and our understanding of errors in the space-based measurements will provide new insights for studies of the Earth. The ....Establishing the reference frame using astronomical and space-geodetic observations. Australia is increasingly dependent on spatial positioning and spatial data, yet mostly relies upon international agencies and research organisations to provide regular updates of coordinates and reference frame definition used on Earth. Improving the accuracy of the reference frame definition and our understanding of errors in the space-based measurements will provide new insights for studies of the Earth. The research will yield results in studies of national significance, such as sea level rise, the effects of melting polar regions, and crustal deformation, as well as developing Australia's expertise in exploiting observations of the Earth from space.Read moreRead less
Novel dating methods for marine sediments of relevance to determining past climate changes. Future climate change is a subject of enormous contemporary interest with economic and social implications for much of humanity. Accurate knowledge of past climates is, however, crucial to understanding how the global climate will evolve into the future. This proposal aims to develop novel methods for dating marine sediments using cosmogenic isotopes, in order to extract the palaeoclimatic signals that ar ....Novel dating methods for marine sediments of relevance to determining past climate changes. Future climate change is a subject of enormous contemporary interest with economic and social implications for much of humanity. Accurate knowledge of past climates is, however, crucial to understanding how the global climate will evolve into the future. This proposal aims to develop novel methods for dating marine sediments using cosmogenic isotopes, in order to extract the palaeoclimatic signals that are locked into these sediments. We will concentrate on the Southern Ocean which plays a crucial role in the world's climate. This proposal will also contribute to Australia's international obligation to conduct research in this critical area.Read moreRead less
A fundamental study of electronic transport in advanced semiconductor nanostructures. The principal aim of this project is to attract and retain very high calibre early career researchers by providing them with the best-available infrastructure and research environment, combined with world-class supervision and mentoring. The project brings together an outstanding team of international collaborators, who will work with the early career researchers to ensure that they are trained and mentored at ....A fundamental study of electronic transport in advanced semiconductor nanostructures. The principal aim of this project is to attract and retain very high calibre early career researchers by providing them with the best-available infrastructure and research environment, combined with world-class supervision and mentoring. The project brings together an outstanding team of international collaborators, who will work with the early career researchers to ensure that they are trained and mentored at an international level. The new science, novel characterisation methods, and theoretical models that are outcomes of this project will provide new opportunities and expertise to advance the strategic defence and national security interests of Australia, and the emerging Australian semiconductor device and solar cell industry. Read moreRead less
Geophysical, Galactic, and Extra-Galactic Science with the AuScope and Australian Pathfinder Arrays. Two new radio telescope arrays are under construction in Australia. One is the Australian Square Kilometre Array Pathfinder, near Geraldton. The other is a very long baseline array with antennae near Hobart, Katherine, and Yarragadee. These three antennae work together to observe radio sources far away across the universe. Their observations are used to establish a very accurate coordinate syste ....Geophysical, Galactic, and Extra-Galactic Science with the AuScope and Australian Pathfinder Arrays. Two new radio telescope arrays are under construction in Australia. One is the Australian Square Kilometre Array Pathfinder, near Geraldton. The other is a very long baseline array with antennae near Hobart, Katherine, and Yarragadee. These three antennae work together to observe radio sources far away across the universe. Their observations are used to establish a very accurate coordinate system or reference frame on the earth, to which the global positioning system is aligned. This program will use these new radio telescope arrays to study the Milky Way and other galaxies, and to study continental drift and sea-level rise on the Earth.Read moreRead less