Partnering With Patients To Transform Practice And Policy For Improved Patient-centred Outcomes In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$3,292,932.00
Summary
Chronic kidney disease (CKD) is a major cause of death and imposes a substantial burden on individuals and the healthcare system worldwide. In partnership with patients, this project will establish and implement core outcomes and measures. Patient-centred trials will address the research priorities of patients across all stages of CKD including: preventing the progression of CKD, improving fatigue in patients on dialysis, and optimising life participation in kidney transplant recipients.
Enhancing and evaluating stakeholder engagement for improved water outcomes. Stakeholder engagement, widely recognised as essential in successful water governance, remains ad hoc both in practice and as a research theme. Using a detailed analysis of a complex evolutionary case of stakeholder engagement in water management in the Murray-Darling Basin (1900- 2020), this project aims to develop new approaches to measure the structure and form of socio-culturally derived stakeholder engagement syste ....Enhancing and evaluating stakeholder engagement for improved water outcomes. Stakeholder engagement, widely recognised as essential in successful water governance, remains ad hoc both in practice and as a research theme. Using a detailed analysis of a complex evolutionary case of stakeholder engagement in water management in the Murray-Darling Basin (1900- 2020), this project aims to develop new approaches to measure the structure and form of socio-culturally derived stakeholder engagement system, to improve socio-economic and environmental benefits from water. The expected output is a new diagnostic tool for evaluating stakeholder engagement that can be taken up by governing bodies. The expected benefit is more inclusive, equal, and adaptive water governance through more effective stakeholder engagement.Read moreRead less
Fostering school attendance for students in Out-of-Home Care. This project aims to investigate why children and young people in Out-Of-Home-Care in Australia are absent from school far more than their peers. The project expects to generate new knowledge about the reasons for their absences and to develop solutions to improve attendance through: children’s own voices; detailed absence data; policy audit; and case studies of promising practice. Expected outcomes include a comprehensive conceptuali ....Fostering school attendance for students in Out-of-Home Care. This project aims to investigate why children and young people in Out-Of-Home-Care in Australia are absent from school far more than their peers. The project expects to generate new knowledge about the reasons for their absences and to develop solutions to improve attendance through: children’s own voices; detailed absence data; policy audit; and case studies of promising practice. Expected outcomes include a comprehensive conceptualisation of absences including those triggered by schools or the care context; and an evidence-informed, child-centred framework to enable attendance and, thereby, improved educational outcomes. This should provide significant social and economic benefits both for children in care and for the community. Read moreRead less
Designing for Communities with Communities: Co-designing Public Libraries. Public libraries are critical social infrastructure for communities across Australia. This project investigates how to involve community participation in the design of their public library spaces by analysing the efficacy of co-design activities introduced into three case studies. New knowledge will be generated about engaging community participation in the design and re-design of library spaces, as the societal role of p ....Designing for Communities with Communities: Co-designing Public Libraries. Public libraries are critical social infrastructure for communities across Australia. This project investigates how to involve community participation in the design of their public library spaces by analysing the efficacy of co-design activities introduced into three case studies. New knowledge will be generated about engaging community participation in the design and re-design of library spaces, as the societal role of public libraries continues to expand. Expected outcomes include an online guide and overarching framework, and blueprints for community participation that ensure genuine engagement and input.Read moreRead less
Play about Place: Expanding the impact of Creative Placemaking after COVID. This project aims to establish a new approach to placemaking through the development of urban play projects. The project expects to generate affordable and engaging experiences that activate existing public spaces, a typology and methodology for analysing the impacts of urban play, and a comparative study of urban play in Melbourne and Christchurch. Expected outcomes include creative placemaking strategies and projects, ....Play about Place: Expanding the impact of Creative Placemaking after COVID. This project aims to establish a new approach to placemaking through the development of urban play projects. The project expects to generate affordable and engaging experiences that activate existing public spaces, a typology and methodology for analysing the impacts of urban play, and a comparative study of urban play in Melbourne and Christchurch. Expected outcomes include creative placemaking strategies and projects, a connected impact study, and an industry resource for local government outlining our approach. This should provide significant benefits, including First Peoples storytelling experiences, city activation post-pandemic, community engagement, the potential to create jobs and provide economic and social benefit for Australia.Read moreRead less
Public lessons, private interests: Do inquiries promote industry change? Mineral resource extraction is increasingly contentious and conflictual. Leading global companies are responding to high profile issues by commissioning independent inquiries into past events with the reports released publicly. Little is known about the governance arrangements of these inquiries, their independence, or their role in stimulating change. This project aims to investigate the utility of independent inquiries co ....Public lessons, private interests: Do inquiries promote industry change? Mineral resource extraction is increasingly contentious and conflictual. Leading global companies are responding to high profile issues by commissioning independent inquiries into past events with the reports released publicly. Little is known about the governance arrangements of these inquiries, their independence, or their role in stimulating change. This project aims to investigate the utility of independent inquiries commissioned by global mining companies for different stakeholder groups. By drawing comparisons with government-led commissions of inquiry, the project aims to develop guidelines for industry inquiries to achieve meaningful change and improve resource governance outcomes globally.Read moreRead less
Industrial disasters, disclosure deficit: Can transparency level the field? This project aims to identify and apply innovative forms of transparency and new processes of public accountability for energy transition minerals. Recent tailings dam disasters have damaged the global mining industry’s reputation, eroded public trust, weakened investor confidence, and raised new challenges for insurers and other stakeholders. Companies are under intense pressure to disclose information about their activ ....Industrial disasters, disclosure deficit: Can transparency level the field? This project aims to identify and apply innovative forms of transparency and new processes of public accountability for energy transition minerals. Recent tailings dam disasters have damaged the global mining industry’s reputation, eroded public trust, weakened investor confidence, and raised new challenges for insurers and other stakeholders. Companies are under intense pressure to disclose information about their activities and satisfy a concerned public that they are not putting people and the environment at risk. The research will benefit end users by improving Australia’s ability to maximise its mineral resource endowment, supporting the transition to low-carbon technology, and safeguarding these assets for future generations.Read moreRead less
Advancing investor action on energy transition. This project aims to advance action by investors (debt and equity) to increase finance for low-carbon energy sources that reduce fundamental climate risks. The project applies interdisciplinary approaches to generate new knowledge about the business case for investor leadership on energy transition and supportive climate law and financial regulatory frameworks. Collaborative legal and business analysis by leading Australian and US scholars, coupled ....Advancing investor action on energy transition. This project aims to advance action by investors (debt and equity) to increase finance for low-carbon energy sources that reduce fundamental climate risks. The project applies interdisciplinary approaches to generate new knowledge about the business case for investor leadership on energy transition and supportive climate law and financial regulatory frameworks. Collaborative legal and business analysis by leading Australian and US scholars, coupled with interviews and focus groups with investors, will examine contemporary engagement practices and investors' management of climate-related financial risks. Expected outcomes are targeted reform proposals to benefit policymakers and the environment by fostering private financing of clean energy.Read moreRead less
Diagnostic Detection Of Aquatic Pathogens Using Real-time Next Generation Sequencing
Funder
Fisheries Research and Development Corporation
Funding Amount
$216,000.00
Summary
Current diagnostic programs generally rely on highly -specific assays for pathogen detection. While these techniques are invaluable, they are one dimensional and do not provide detailed information critical to a disease investigation. These gaps include the inability to detect unknown pathogens and potential variants of know pathogens and provide no additional genomic or transcriptomic data. Moreover, samples must be shipped to trained personnel in a laboratory, further delaying the time to diag ....Current diagnostic programs generally rely on highly -specific assays for pathogen detection. While these techniques are invaluable, they are one dimensional and do not provide detailed information critical to a disease investigation. These gaps include the inability to detect unknown pathogens and potential variants of know pathogens and provide no additional genomic or transcriptomic data. Moreover, samples must be shipped to trained personnel in a laboratory, further delaying the time to diagnosis. The MinION, on the other hand, can theoretically detect any pathogen and can potentially be deployed to the field. Moreover, the MinION can rapidly generate full-length genomes, allowing for epidemiological tracking of viral or bacterial strains in near real-time. Such rapid data, which cannot be obtained as quickly using existing methods, are vital if the intention is to intervene in an outbreak and reduce impacts on the productivity and profitability of aquaculture facilities. For example, a rapid, early diagnosis may allow mitigating actions to be taken on-farm, such as the diversion of intake water, movement restrictions of stock and the isolation of infected ponds. These qualities make the MinION an attractive complimentary platform to fill several gaps in the data obtained during disease outbreak investigations, or routine diagnostics, and potentially for use in the field. However, results from the misuse or lack of understanding of the technology could also have adverse regulatory implications for aquaculture industries. For example, without appropriate guidelines, an inexperienced diagnostician may misinterpret a distant DNA match in a pathogen database as a significant result, this may create unwanted attention to industry and potential stock destruction or changes to disease status that are unjustified. Thus, it is critical that the MinION is evaluated at the Australian Animal Health Laboratory, and guidelines and procedures are developed for accurate diagnostic evaluations. The activities detailed in this application will establish the feasibility of using the MinION for diagnostic applications, and ensure that the data is reliably generated and interpreted appropriately.
Objectives: 1. Evaluate if MinION data meets or exceeds the data obtained using established laboratory-based NGS platforms. Objectives (1) and (2) align with Methods section (1).The first objective of this project is to demonstrate if the MinION can obtain quality genome assemblies of known pathogens, such as WSSV, AHPND, OsHV-1 and HaHV that have been created using existing NGS technology. Moreover, determine if the MinION is capable of producing a diagnostic result more rapidly and with greater confidence than traditional techniques. STOP/GO POINT: If MinION data does not produce reliable genome assemblies, no improvement in genome quality, or is significantly more laborious to set-up/run or analyse than existing NGS technologies, do not proceed with objective 2. 2. Evaluate the performance of the MinION using existing diagnostic extraction techniques and produce robust methods and protocols for sample preparation, sequencing and data analysis. This objective will optimise MinION protocols for sample pre-processing, optimal sequencing conditions, and data post-processing. We will then evaluate the MinION data produced from a range of aquatic organisms against data produced using traditional techniques from the same samples. STOP/GO POINT: If after these optimisations, the MinION cannot detect pathogens as reliably as traditional techniques, do not proceed with objective 3. 3. Compare the applicability of MinION to standard molecular assays for identification of pathogens in diagnostic samples. Objective (3) is aligned with Methods section (2).In this objective, diagnostic samples will be tested using existing diagnostics tools (qPCR, cPCR) and MinION sequencing. Analysis between the methods will be detailed, including time to result, pathogen identity and genomic information. This objective will not only provide an insight into real-time sequencing for diagnostics, but in addition the feasibility of MinION technology for field application in the future. Read moreRead less
Redesigning workers’ compensation using participatory systems modelling. This project will use participatory system modelling techniques to develop and test new approaches to the design and delivery of workers' compensation in Australia. The project responds to the substantial evidence that Australia’s workers' compensation systems are failing to achieve their social and economic objectives. We will actively engage people with lived experience of work disability to co-design an alternative worke ....Redesigning workers’ compensation using participatory systems modelling. This project will use participatory system modelling techniques to develop and test new approaches to the design and delivery of workers' compensation in Australia. The project responds to the substantial evidence that Australia’s workers' compensation systems are failing to achieve their social and economic objectives. We will actively engage people with lived experience of work disability to co-design an alternative workers' compensation system. The outcomes of this system will be assessed using agent-based modelling, and compared to the current state. The study will provide a vision for an alternative approach to workers' compensation that supports the social and economic participation of Australians with work disability.
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