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Prof Khachigian is a vascular cell and molecular biologist elucidating fundamental transcriptional mechanisms that lead to the inappropriate expression of harmful genes in vascular cells. Exploiting this science, I am also a “translational” researcher who has pioneered the development of novel strategies targeting key regulatory genes to combat angiogenesis-dependent cancers, and potentially other common vascular disorders such as post-angioplasty restenosis, bypass graft stenosis, ocular neovas ....Prof Khachigian is a vascular cell and molecular biologist elucidating fundamental transcriptional mechanisms that lead to the inappropriate expression of harmful genes in vascular cells. Exploiting this science, I am also a “translational” researcher who has pioneered the development of novel strategies targeting key regulatory genes to combat angiogenesis-dependent cancers, and potentially other common vascular disorders such as post-angioplasty restenosis, bypass graft stenosis, ocular neovascularisation and rheumatoid arthritis.Read moreRead less
Neurogenic Mechanisms Of Cardiovascular Risk In The Metabolic Syndrome: Benefits Of Lifestyle Interventions
Funder
National Health and Medical Research Council
Funding Amount
$328,194.00
Summary
One in four adult Australians has the 'metabolic syndrome' (MetS), a clustering of metabolic and heart disease risk factors associated with abdominal obesity. Sympathetic nervous system (SNS) activity is increased in the MetS resulting in enhanced release of the stress hormone 'noradrenaline' . This project will examine the biological and genetic determinants of enhanced SNS activity and the benefits of lifestyle interventions (weight loss, weight loss maintenance and aerobic exercise).
Angiopoietin-2, Aortic Inflammation And Cardiovascular Events
Funder
National Health and Medical Research Council
Funding Amount
$332,161.00
Summary
Based on detailed preliminary data, we plan to investigate the importance of a novel protein (the cytokine angiopoietin-2) in cardiovascular disease. The results of this study will clarify the role of this cytokine in vascular pathology and may provide an important target for novel therapy and-or diagnostic markers for cardiovascular disease progression.