Quantum coherence of electronic transport in layered magnetoresistive materials. The continued rapid expansion of information technology requires new materials and devices for information storage. State of the art computer memories are based on new materials which consist of layers of complex arrays of atoms. These materials have metallic properties quite unlike those of simple metals such as copper and steel. This research will lead to a greater understanding of and ability to design better ma ....Quantum coherence of electronic transport in layered magnetoresistive materials. The continued rapid expansion of information technology requires new materials and devices for information storage. State of the art computer memories are based on new materials which consist of layers of complex arrays of atoms. These materials have metallic properties quite unlike those of simple metals such as copper and steel. This research will lead to a greater understanding of and ability to design better materials. Australia's capacity for research and development in this scientifically challenging and technologically important field will be enhanced by this project. Read moreRead less
Biomolecular optoelectronic materials and devices. The melanins are the molecules in our skin, eyes and hair that provide colour and protection from the sun. In addition to being important bio-molecules, they have properties which make them useful for high tech applications especially in electronics and optoelectronics. Unfortunately, our current understanding of these fascinating materials is poor. In our project we aim to solve this limiting problem. We will develop new science to explain thei ....Biomolecular optoelectronic materials and devices. The melanins are the molecules in our skin, eyes and hair that provide colour and protection from the sun. In addition to being important bio-molecules, they have properties which make them useful for high tech applications especially in electronics and optoelectronics. Unfortunately, our current understanding of these fascinating materials is poor. In our project we aim to solve this limiting problem. We will develop new science to explain their behaviour, and use this knowledge to create bio-compatible hi-tech materials and devices. We anticipate significant benefits from the perspectives of basic science and utilisation of biomaterials for new green technologies.Read moreRead less
Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to rev ....Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to revolutionise many aspects of modern life, from computing and communications, to medical imaging and metrology. This project will put Australia at the international forefront of quantum imaging, enhancing Australia's already significant international presence in the area.Read moreRead less
Light scattering in complex mesoscale systems. The aim of the proposed project is to develop tested theoretic models of, and test applications of, the scattering of light in complex mesoscale systems. This will include: light scattering by biological cells, including optical cancer detection, remote sensing of cell populations, flow cytometry and optical tweezers; optically driven micromachines, and nano- and micro-structured materials. These applications are of considerable technological, socia ....Light scattering in complex mesoscale systems. The aim of the proposed project is to develop tested theoretic models of, and test applications of, the scattering of light in complex mesoscale systems. This will include: light scattering by biological cells, including optical cancer detection, remote sensing of cell populations, flow cytometry and optical tweezers; optically driven micromachines, and nano- and micro-structured materials. These applications are of considerable technological, social, and economic importance, and significant advances are possible. Methods developed during this project will allow accurate theoretical calculations to be performed where only inadequate approximations have previously been possible.Read moreRead less
Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle d ....Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle deposition in human lung through experimental studies and advanced modelling. The program will enhance and strengthen the existing collaboration between the universities and its outcome will be of significance in the vital area of human health and risk assessment.Read moreRead less
Naturally Photoactive Biopolymers. The basic aim of this project is to assess the viability of using semiconducting biopolymers from the melanin family of macromolecules in photoactive device based applications. In order to do this, key optical, structural, electronic, and photochemical properties will be assessed on thin films in the solid state. The melanins are the only known semiconducting biopolymers, and are non-toxic, biocompatible and biodegradable. Their use as ?active? materials in ....Naturally Photoactive Biopolymers. The basic aim of this project is to assess the viability of using semiconducting biopolymers from the melanin family of macromolecules in photoactive device based applications. In order to do this, key optical, structural, electronic, and photochemical properties will be assessed on thin films in the solid state. The melanins are the only known semiconducting biopolymers, and are non-toxic, biocompatible and biodegradable. Their use as ?active? materials in solid state or photo-electrochemical devices has never before been suggested. Specifically, these materials could be used as the light harvesting components in dye sensitised Gratzel cells, or, as the donor material in soft solid photovoltaic junctions. The melanins are also a key class of biomolecules (their involvement in skin cancers is well documented), and hence, any advancement in our understanding of their functions and properties could have biological importance.Read moreRead less
Photoactive Semiconducting Biopolymers. The basic aims of this project are to elucidate, manipulate, and utilise the unique chemical and physical properties of a class of biopolymers called the melanins. These materials are the only known solid state semiconducting biopolymers, and are non-toxic, biocompatible, and biodegradable. Their use as active components in biomimetic soft electonic, optoelectronic or photovoltaic devices, has not hitherto been demonstrated. It is anticipated that the k ....Photoactive Semiconducting Biopolymers. The basic aims of this project are to elucidate, manipulate, and utilise the unique chemical and physical properties of a class of biopolymers called the melanins. These materials are the only known solid state semiconducting biopolymers, and are non-toxic, biocompatible, and biodegradable. Their use as active components in biomimetic soft electonic, optoelectronic or photovoltaic devices, has not hitherto been demonstrated. It is anticipated that the key outcomes from the project will be a demonstration of biopolymer-based photoelectrochemical and solid-state p-i-n solar cells, and an improved understanding of the physics and chemistry of these important biological macromolecules.Read moreRead less
Cytorefractometry - a new technique for refractive index tomography of living cells. An ultrahigh-resolution bifocal optical coherence refractometry is proposed, and will result to micron-scale-resolution refractive index tomography of living cells, termed cytorefractometry. This technique represents an extension from bifocal optical coherence refractometry that has recently shown a remarkable promise for direct, several-frames-per-second, motion-artifact-free determination of refractive index ....Cytorefractometry - a new technique for refractive index tomography of living cells. An ultrahigh-resolution bifocal optical coherence refractometry is proposed, and will result to micron-scale-resolution refractive index tomography of living cells, termed cytorefractometry. This technique represents an extension from bifocal optical coherence refractometry that has recently shown a remarkable promise for direct, several-frames-per-second, motion-artifact-free determination of refractive index in turbid media, including biological tissue in vivo. We propose to apply our novel technique to study tissue calcification, a serious problem in cardiology, by making use of the refractive index contrast mechanism. Calcification of smooth muscle cells and aorta subdermal implant models will be studied aiming for prevention of calcification-associated pathologies.Read moreRead less
Integrated microresonator based quantum technology. We will develop new 21st century physical technologies able to control the microscopic quantum world. These quantum technologies will build off world leading techniques to confine and manipulate light on a silicon chip, and have broad ramifications for future computing, medical, and sensing systems. New quantum architectures will be developed for information science, promising vast improvements over current systems; and new biological sensing s ....Integrated microresonator based quantum technology. We will develop new 21st century physical technologies able to control the microscopic quantum world. These quantum technologies will build off world leading techniques to confine and manipulate light on a silicon chip, and have broad ramifications for future computing, medical, and sensing systems. New quantum architectures will be developed for information science, promising vast improvements over current systems; and new biological sensing systems with world leading sensitivity will be implemented with important applications in the early detection of debilitating diseases. This research will raise Australia's profile as a world leader in science and technology, building on our already significant presence in quantum technology.Read moreRead less
Modelling of transdermal transport using computational molecular simulation. Through molecular simulation, we aim to model the transport of a variety of molecules through lipid bilayers typical of human skin, identifying key transport mechanisms and properties. We anticipate that this work will provide insight into existing transdermal delivery data, helping to identify relations between the physicochemical properties of a molecule and its transport properties. Ultimately, such knowledge can fac ....Modelling of transdermal transport using computational molecular simulation. Through molecular simulation, we aim to model the transport of a variety of molecules through lipid bilayers typical of human skin, identifying key transport mechanisms and properties. We anticipate that this work will provide insight into existing transdermal delivery data, helping to identify relations between the physicochemical properties of a molecule and its transport properties. Ultimately, such knowledge can facilitate the development of more efficient transdermal drug delivery, which offers significant advantages over oral delivery (which leads to high waste and variability due to drug loss in the stomach and liver) and intravenous delivery (which raises compliance issues due to the adverse psychological response of patients).Read moreRead less