Discovery Early Career Researcher Award - Grant ID: DE160100098
Funder
Australian Research Council
Funding Amount
$403,536.00
Summary
Can positronium fragment complex molecules? This project aims to explore whether positronium, which is produced in the body during positron emission tomography (PET), can damage DNA. PET scans are used to locate cancer. Positrons produce positronium, a matter-antimatter bound state, in the body during a PET scan. It is known that electrons can damage DNA by forming a transient negative ion that fragments DNA building blocks and it is suggested that positronium could damage DNA in the same way. T ....Can positronium fragment complex molecules? This project aims to explore whether positronium, which is produced in the body during positron emission tomography (PET), can damage DNA. PET scans are used to locate cancer. Positrons produce positronium, a matter-antimatter bound state, in the body during a PET scan. It is known that electrons can damage DNA by forming a transient negative ion that fragments DNA building blocks and it is suggested that positronium could damage DNA in the same way. This work will explore fragmentation of DNA nucleobases by positronium impact. The results of this work may contribute to new models of PET use.Read moreRead less
Atto-second atomic dynamics. Recent progress in short laser pulse generation allows one to capture electron dynamics on the atomic time scale. The project will aim to combine these new experimental capabilities with detailed quantum mechanical calculations and a new physical approach, which will improve dramatically our ability to gain new knowledge about fundamental atomic processes.
Correlation Effects in Gas-Phase Positron Scattering. This project will apply new, state-of-the-art experimental positron technology in order to gain a deeper understanding of correlations in positron-atom and/or positron-molecule collision systems. The ambitious experimental program will investigate several of the major remaining 'big' questions in positron science. It is expected that the experimental evidence provided for processes such as threshold ionisation, positron bound states, and othe ....Correlation Effects in Gas-Phase Positron Scattering. This project will apply new, state-of-the-art experimental positron technology in order to gain a deeper understanding of correlations in positron-atom and/or positron-molecule collision systems. The ambitious experimental program will investigate several of the major remaining 'big' questions in positron science. It is expected that the experimental evidence provided for processes such as threshold ionisation, positron bound states, and other positronic complexes, will stimulate theoretical calculations in the field and lead to new insights into a number of quantum scattering processes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101024
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
How antimatter and matter solvates in liquids. This project aims to improve solvation in transport calculations and polar liquids. Solvation, the process of a particle becoming trapped in a liquid, is important in Positron Emission Tomography medical imaging. However, this application can only be described through particle transport simulation, which cannot address solvation. Modelling the dynamical solvation process of the electron and the positron, its antimatter counterpart, is expected to en ....How antimatter and matter solvates in liquids. This project aims to improve solvation in transport calculations and polar liquids. Solvation, the process of a particle becoming trapped in a liquid, is important in Positron Emission Tomography medical imaging. However, this application can only be described through particle transport simulation, which cannot address solvation. Modelling the dynamical solvation process of the electron and the positron, its antimatter counterpart, is expected to enable accurate simulation of medical imaging, acquiring the greatest amount of information for the smallest dosage of radiation to the patient allowing for lower patient radiation doses and more informative scans.Read moreRead less
Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements ....Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements, his project aims to determine the number of Auger electrons per nuclear decay accurately for medical isotopes. The outcome will be accurate dose data for radioisotopes, plus essential knowledge to develop new cancer treatments based on Auger electrons, which target a fraction of a cell.Read moreRead less
Time-space resolved photoelectron emission to control molecular processes. This project aims to resolve simultaneously the timing and space localisation of photoelectron emission from atoms and molecules as a means for targeted breaking of molecular bonds. Existing techniques determine the timing and spatial characteristics of photoemission independently. The simultaneous time-space resolution will allow for the precise manipulation of photoelectrons by a sequence of phase-stabilised laser pulse ....Time-space resolved photoelectron emission to control molecular processes. This project aims to resolve simultaneously the timing and space localisation of photoelectron emission from atoms and molecules as a means for targeted breaking of molecular bonds. Existing techniques determine the timing and spatial characteristics of photoemission independently. The simultaneous time-space resolution will allow for the precise manipulation of photoelectrons by a sequence of phase-stabilised laser pulses, a technique known as coherent control. The benefit of this project will be the coherently controlled breaking of molecular bonds in oxide, carbonyl and hydrocarbon molecules. The outcome will be a significant step forward in driving complex photochemical reactions in industry.Read moreRead less
Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of posit ....Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of positron transport in PET. The project will allow validation of predictions from the model by undertaking experiments in liquid water.Read moreRead less
Understanding molecular negative ion production for use in pathology. The project aims to increase the yield of molecular negative ion sources by improving our understanding of the formation of ion beams from plasma sources and expand our knowledge of molecular negative ion generation in plasma environments leading to brighter ion beams. For example, understanding cancer requires cellular level tools to map how cells are changing. These maps are made using ion beams which are scanned across cell ....Understanding molecular negative ion production for use in pathology. The project aims to increase the yield of molecular negative ion sources by improving our understanding of the formation of ion beams from plasma sources and expand our knowledge of molecular negative ion generation in plasma environments leading to brighter ion beams. For example, understanding cancer requires cellular level tools to map how cells are changing. These maps are made using ion beams which are scanned across cells to remove material that is analysed at the atomic and molecular level. Ion beams are produced from plasma sources, but much of their operation is not understood. Such improved ion beams are expected to enable inexpensive and fast cellular level pathology at even small hospitals to tackle cancer for society’s benefit.Read moreRead less
Using high-resolution lasers to test quantum electrodynamics. High-precision laser-based measurements of atomic and molecular structure are benchmarks for our fundamental understanding of matter. This project will undertake state-of-the-art experiments on atomic helium, to test and challenge current theoretical predictions of fundamental quantum-electrodynamic properties for helium and for more complex atoms.
Cold positron interactions with ultracold rubidium atoms. Antiparticles and antimatter have progressed from theory and science fiction to become an important and exciting area of pure and applied science. This fundamental atomic physics project aims to further study how antimatter and matter interact by providing the first comprehensive experimental results for the interaction of positrons (the electron anti-particle) with trapped rubidium atoms in an innovative combination of two cutting-edge ....Cold positron interactions with ultracold rubidium atoms. Antiparticles and antimatter have progressed from theory and science fiction to become an important and exciting area of pure and applied science. This fundamental atomic physics project aims to further study how antimatter and matter interact by providing the first comprehensive experimental results for the interaction of positrons (the electron anti-particle) with trapped rubidium atoms in an innovative combination of two cutting-edge atomic physics techniques. It aims to provide measurements of many fundamental interaction quantities and for collisions between matter and antimatter. This will look to test the latest quantum theoretical approaches and further our understanding of the uses of antimatter in medical and materials science.Read moreRead less