Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and l ....Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and lift productivity by managing innovation for Australia’s industries.Read moreRead less
Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluid ....Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluidic drying approach. The potential applications of iNPs are wide-ranging and are not restricted to pulmonary targeting. The potential commercial implications for Australia's emerging biopharmaceutical industry are substantial.Read moreRead less
Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
High value micron-sized particles from a novel antisolvent vapour spray drying system. Convective antisolvent precipitation is a novel route in producing particles from spray drying by adding an anti-solvent to the drying medium. This project will allow conventional spray dryers to produce more sophisticated ultrafine and encapsulated particles for use in food, pharmaceuticals and other high value applications.
Micromechanical analysis of size segregation and its prediction in granular free-surface flows. Industries often suffer from size segregation in the handling and processing of granular materials, leading to significant economic consequences. This project aims to develop a fundamental understanding of size segregation and prediction models, enabling industries to eliminate, minimise, or manage the effects to an acceptable level.
Perfect particles: Accurate breakage predictions by 3D printing of granules. Granule breakage of micro-structured specialty products impedes manufacturing and degrades product performance. Predictive breakage models have had limited success as each granule has a unique structure. Differences between the model predictions and experimental breakage test results could be due to inaccurate models or irreproducible experimental results due to granule structure differences. This project is expected to ....Perfect particles: Accurate breakage predictions by 3D printing of granules. Granule breakage of micro-structured specialty products impedes manufacturing and degrades product performance. Predictive breakage models have had limited success as each granule has a unique structure. Differences between the model predictions and experimental breakage test results could be due to inaccurate models or irreproducible experimental results due to granule structure differences. This project is expected to be the first ever application of three-dimensional printing for reproducible breakage testing. The project aims to: create the first ever multiple identical copies of complex granules using polyjet three-dimensional printing; model and experimentally measure granule breakage; and develop sophisticated Digital Elevation Models of granule breakage for practical use in industry.Read moreRead less
Towards New Functionality in Dairy Ingredients. The Australian dairy industry plays a significant part in the nation’s economy, with almost $3 billion in export revenue in 2016-2017. Powdered dairy products extend shelf life and ease of transport, with >20% annual growth in premium products, such as milk protein concentrates and infant formula powders. This project aims to support the development of value-added dairy powders by investigating the impact of a novel high pressure processing technol ....Towards New Functionality in Dairy Ingredients. The Australian dairy industry plays a significant part in the nation’s economy, with almost $3 billion in export revenue in 2016-2017. Powdered dairy products extend shelf life and ease of transport, with >20% annual growth in premium products, such as milk protein concentrates and infant formula powders. This project aims to support the development of value-added dairy powders by investigating the impact of a novel high pressure processing technology in enhancing the properties of dairy powders and/or introducing new functionality. Successful outcomes will help expand the offering of high value dairy ingredients and thus increase the global competitiveness of Australian dairy manufacturing.Read moreRead less
Predictive Tools for Effective Spray Drying of Heat Sensitive Dairy Powders. This project is a joint international effort between Monash University, the Institute of Dairy Ingredients Processing at South Dakota State University, and the Dairy Research Institute to address challenges in achieving optimum spray drying conditions for heat sensitive dairy powders, such as milk protein concentrates and whey powders. The new modelling tool aims to help in predicting effective spray drying conditions t ....Predictive Tools for Effective Spray Drying of Heat Sensitive Dairy Powders. This project is a joint international effort between Monash University, the Institute of Dairy Ingredients Processing at South Dakota State University, and the Dairy Research Institute to address challenges in achieving optimum spray drying conditions for heat sensitive dairy powders, such as milk protein concentrates and whey powders. The new modelling tool aims to help in predicting effective spray drying conditions to produce powders with improved solubility, emulsification, and heat stability properties. It is expected that the dairy industry will benefit from the use of this technology to deliver milk powders with improved quality, functionality, and shelf-life.Read moreRead less
Particle-scale modelling of particle-fluid flows in gas and oil extraction. Particle-scale modelling of particle-fluid flows in gas and oil extraction. This project aims to develop a particle scale model to study the pipeline transport of petroleum fluids. It will use a combined theoretical and experimental program, involving state-of-the-art discrete element modelling and simulation techniques, to describe the complex particle-fluid flow and erosion of pipeline transport in gas and oil extracti ....Particle-scale modelling of particle-fluid flows in gas and oil extraction. Particle-scale modelling of particle-fluid flows in gas and oil extraction. This project aims to develop a particle scale model to study the pipeline transport of petroleum fluids. It will use a combined theoretical and experimental program, involving state-of-the-art discrete element modelling and simulation techniques, to describe the complex particle-fluid flow and erosion of pipeline transport in gas and oil extraction, quantify the effects of key variables, and formulate strategies for optimum process control under different conditions. The research outcomes are expected to be useful for the process control of pipeline transport in Australia’s important petroleum and energy-related industries.Read moreRead less
Scalable fabrication of novel mesoporous carbonaceous spheres with uniform size as effective adsorbents in water treatment. A productive route to generate mesoporous microspheres as highly effective adsorbents for toxins from algae blooms is proposed via an innovative drying technology. A breakthrough will be achieved in the practical development of novel adsorbents to ensure the availability of clean freshwater with enormous impacts for communities around Australia.