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A Prospective Study Of Parental Outcomes Following Prenatal Or Postnatal Diagnosis Of Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$289,400.00
Summary
Congenital heart disease (CHD) is the leading non-infectious cause of infant death in Australia. It is now possible to diagnose babies with CHD while in the womb. However, little is known about how parents respond to a diagnosis of CHD during pregnancy. This unique study will examine and compare parents' experiences following prenatal or postnatal diagnosis of CHD, with the aim of developing clinical services and resources for the supportive care of parents and their infants.
Molecular Mechanisms Of Ivermectin Resistance In The Ectoparasitic Mite, Sarcoptes Scabiei
Funder
National Health and Medical Research Council
Funding Amount
$289,561.00
Summary
A largely neglected parasitic disease, scabies is a significant disease of children, particularly in remote Aboriginal communities in northern Australia. The recent emergence of ivermectin resistance threatens future control of scabies. This research explores the genetic basis of ivermectin resistance in the scabies mite, developing molecular markers to identify the emergence of resistance in the community, leading to improved tools for resistance management and sustainable treatment strategies.
Determining The Impact Of Pharmaceutical Opioid Use In Australia: A Focus On Burden, Risks And Harms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Despite a dramatic increase in opioid use in Australia and increasing concern about this issue, there are few detailed and robust data on the magnitude of opioid use in the community, and the characteristics of those at risk of adverse outcomes. This program of work will produce unique population-level evidence about the burden, risks and health consequences of opioid use in Australia, to better inform future policies and interventions regarding opioid prescribing to improve clinical outcomes.
Systems Analyses Of Prostate Cancer Organoid Cultures For Precision Medicine
Funder
National Health and Medical Research Council
Funding Amount
$430,766.00
Summary
During this fellowship a research platform will be established that can efficiently predict new treatment combinations for prostate cancer. To do this, computational analyses of patient prostate cancer “organoid” cultures subjected to a panel of therapeutic drugs will be performed, to predict effective treatment combinations for any tumour of interest. Accordingly, this work will establish a foundation to decipher successful treatment regimes on an individual patient basis.
Characterisation Of CFAE Wavefront Propogation In Human Persistent AF
Funder
National Health and Medical Research Council
Funding Amount
$418,612.00
Summary
Atrial fibrillation can be eliminated by a relatively new treatment called catheter ablation, which involves modification of the electrical properties of the heart using thin wires (catheters) passed up from the leg. Targeting areas where catheters record abnormal electrical activity improves results of catheter ablation, although it is uncertain what these recordings represent. The aim of this study is to characterize these abnormal electrical signals in an attempt to improve ablation outcomes.
The focus of this research is the integration of innovative evidence-based, personalised physical activity behaviour change programs that can be delivered via print, web/email, telephone and mobile text-messaging into clinical settings. This research will evaluate the effectiveness of initiating these interventions at the point of interaction between patients and health professionals in current clinical environments for the purpose of improving physical activity levels amongst inactive patients.
Understanding What Works: Examining Innovative Internet-delivered Self-help Treatments For Chronic Pain
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Chronic pain is a common chronic medical condition and results in substantial personal and economic burden for individuals, their families and society. Unfortunately, access to effective care is limited, but internet-delivered cognitive behaviour therapy (iCBT) may improve access to treatment. The proposed research seeks to examine what makes iCBT efficacious for chronic pain and how outcomes may be facilitated using technology-assisted behaviour change strategies.
Improving Outcomes In Obstructive Sleep Apnoea Through Individualised Treatment Of Physiological Abnormalities
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
The most common treatment for obstructive sleep apnoea, continuous positive airway pressure, is only accepted by ~50% of patients. Individualised treatment options are urgently needed. In order to predict who will benefit from the common alternative therapies, my research will show how, upper airway surgery improves obstructive sleep apnoea at an individual level and develop tools that will help clinicians select patients for these therapies.
Maximising Treatment Participation Among Heroin Users Released From Prison
Funder
National Health and Medical Research Council
Funding Amount
$320,580.00
Summary
People who use heroin commonly spend time in prison. Contact with treatment services after release from prison is important for reducing the risk that released heroin users will return to regular drug use. However, we know that few heroin users enter or are retained in treatment after release from prison. This project aims to examine how opioid pharmacotherapy in prison affects the probability that someone will enter, and stay in, treatment after they are released from prison.
Examination Of The Trajectories And Health Consequences Of Pharmaceutical Opioid Use In Australia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The profile of illicit opioid use in Australia has shifted over the past decade, with fewer new heroin users and substantial increases in extra-medical pharmaceutical opioid use. This Fellowship utilises longitudinal and health surveillance data to examine pharmaceutical opioid use and health consequences among growing and hidden populations. It will provide important new evidence for how best to improve the prescribing of pharmaceutical opioids and respond to illicit opioid use.