Epidemiology of pathogens in wildlife populations: significance for conservation, human health and livestock. Recent research shows that pathogens may play a central role in wildlife population dynamics. Emergent disease problems in humans and livestock may result from reservoir infections in wildlife. However, methods to determine the impact of pathogens on populations, as distinct from individuals within populations, are poorly developed, as are models necessary to evaluate alternative control ....Epidemiology of pathogens in wildlife populations: significance for conservation, human health and livestock. Recent research shows that pathogens may play a central role in wildlife population dynamics. Emergent disease problems in humans and livestock may result from reservoir infections in wildlife. However, methods to determine the impact of pathogens on populations, as distinct from individuals within populations, are poorly developed, as are models necessary to evaluate alternative control strategies for pathogens, particularly where reservoir hosts are involved. This project will develop these methods using four case studies: chyridiomycosis in frogs, Hendra virus in bats, Newcastle disease in wild birds and arboviruses in kangaroos and other macropods.Read moreRead less
Understanding The Likely Population Impact Of New And Improved Influenza Vaccines
Funder
National Health and Medical Research Council
Funding Amount
$358,678.00
Summary
Influenza causes a large burden of death and disease each year, as well as disruptive pandemics. Vaccines that could protect against more than one season�s flu strains (including new pandemic viruses) would be highly desirable, and may be on the horizon. Our aim is to understand the likely impact of these new vaccines on the way flu viruses spread between people, and change from one season to the next. This information is needed to justify their introduction, and inform their best use.
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
Genomics Dissection And Prevention Of Bacterial Transmission Events
Funder
National Health and Medical Research Council
Funding Amount
$891,290.00
Summary
This project aims at improving public health capacity to limit the spread of infectious diseases in hospital and community settings. The multi-disciplinary team of investigators will link epidemiological data with the finest resolution data from bacterial genomes in order to pinpoint events of infection transmission between individuals. Two high-burden pathogens (golden staph and food-borne Salmonella) will be used as exemplars of infectious diseases with different biology and modes of spread.
Tuberculosis In The Asia-Pacific: Identification And Comparison Of Transmission Hot Spots
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
The Asia-Pacific is home to 60% of the global burden of tuberculosis and an increasing proportion of Australia's immigrant population. Although most targets relating to this disease are likely to be achieved, patterns of tuberculosis transmission in the Asia-Pacific are not fully understood and the possibility of regional hotspots exists. We aim to use mathematical techniques to examine the way in which tuberculosis is transmitted from person to person in populations within our region.
Predicting Malaria and Other Vector-borne Disease Risk Using Eco-epidemiological Models. The project will benefit the nation by safeguarding public health through modelling and assessing the risk of malaria and other mosquito-borne diseases such as Ross River virus and Dengue. Direct benefits will include reduced or managed risk of these mosquito-borne diseases along with a more efficient allocation of public health resources. Direct and indirect benefits will also flow to Indonesia by reducin ....Predicting Malaria and Other Vector-borne Disease Risk Using Eco-epidemiological Models. The project will benefit the nation by safeguarding public health through modelling and assessing the risk of malaria and other mosquito-borne diseases such as Ross River virus and Dengue. Direct benefits will include reduced or managed risk of these mosquito-borne diseases along with a more efficient allocation of public health resources. Direct and indirect benefits will also flow to Indonesia by reducing death and illness associated with malaria and other mosquito-borne diseases. This project will further the international collaboration already begun with Indonesia and has the potential to extend into other South-East Asian countries. Read moreRead less
Modelling and Simulation of Disease Spread Dynamics Using Interacting Automata. Modelling and simulation techniques will be developed to strengthen our understanding of disease spread over the landscape, so allowing timely control strategies to be developed. The economic cost to Australia of introduced pests, animal and plant diseases is considerable. We utilise an interacting automata formalism to capture landscape, population and contagion information as it affects disease spread to provide ....Modelling and Simulation of Disease Spread Dynamics Using Interacting Automata. Modelling and simulation techniques will be developed to strengthen our understanding of disease spread over the landscape, so allowing timely control strategies to be developed. The economic cost to Australia of introduced pests, animal and plant diseases is considerable. We utilise an interacting automata formalism to capture landscape, population and contagion information as it affects disease spread to provide more accurate simulation than is done at present. Generic simulation tools will be constructed, capable of being rapidly personalised by epidemiologists for specific diseases.Read moreRead less
Defining Optimal Strategies For Sustained Control Of Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
My work helps us understand how infections spread between people, to work out the most effective use of vaccines and other protective measures. This fellowship will support research into the ways large family size, poor health care access, social connections and the environment increase infection risk in settings of poverty. We will find better ways to prevent infectious diseases in the populations worst affected, including Indigenous Australians and people living in low-income countries.
Does Environmental Change Drive The Spatiotemporal Transmission Dynamics Of Echinococcus Spp. In Ningxia, China?
Funder
National Health and Medical Research Council
Funding Amount
$654,548.00
Summary
Human echinococcosis is a chronic debilitating disease with a death rate that can exceed 90%. In China it is a major public health issue where recent environmental changes are likely to increase transmission rates, thus increasing the disease burden. This project will assess the impact of these environmental changes on the transmission of this disease over space and time, it will predict where new cases will arise, and determine the best methods for sustainable control and then elimination.