I am a neurochemist-clinical research scientist investigating the interaction between, in particular, brain monoaminergic activity, autonomic function and physiological responses. My studies are largely focussed on determining the aetiology and consequenc
Modulation And Trafficking Of SK Channels In The Lateral Amygdala
Funder
National Health and Medical Research Council
Funding Amount
$260,980.00
Summary
The amygdala is a brain structure that underlies emotional processing. Malfunctions in emotional processing are thought to be the cause of anxiety disorders. Understanding amygdala physiology is thus vital for developing therapies to treat these disorders. We have recently found a novel role for an ion channel in controlling amygdala excitability. In this grant we will investigate how this ion channel is modulated, which will elucidate a novel way in which activity in the amygdala is regulated.
A Brain-based Model Of Anxiety Sensitivity In Panic Disorder
Funder
National Health and Medical Research Council
Funding Amount
$402,214.00
Summary
This project will combine advanced brain imaging and brain network modelling to better understand the neurobiology of panic disorder with relevance to its treatment.
Cardiovascular Responses To Stress And Arousal: Hypothalamic And Brainstem Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$566,468.00
Summary
Stressful episodes in everyday life cause increases in blood pressure, mainly via activation of nerves that constrict blood vessels and increase heart rate. This in turn increases the risk of heart attacks, strokes, or other cardiovascular diseases. This project aims to identify the brain mechanisms that cause these stress-evoked effects. This knowledge may lead to much more effective ways of minimising stress-evoked responses, and thus reduce the risk of cardiovascular disorders.
A Randomised Controlled Trial Of Internet-based Therapy For Panic Disorder.
Funder
National Health and Medical Research Council
Funding Amount
$202,575.00
Summary
Approximately 9.7% of the adult population have an anxiety disorder with one of the more common, panic disorder, often with agoraphobia, afflicting 2.4% of the community. Around 8% of patients consulting a GP also have panic disorder (PD). A further 10% of the community experience spontaneous panic, but do not have full PD (termed non-clinical panic). People with PD frequently experience clinical depression, about 15% abuse alcohol and non-prescription drugs and PD is associated with an increase ....Approximately 9.7% of the adult population have an anxiety disorder with one of the more common, panic disorder, often with agoraphobia, afflicting 2.4% of the community. Around 8% of patients consulting a GP also have panic disorder (PD). A further 10% of the community experience spontaneous panic, but do not have full PD (termed non-clinical panic). People with PD frequently experience clinical depression, about 15% abuse alcohol and non-prescription drugs and PD is associated with an increased risk of suicide. Over time people with PD appear to have an increased risk of heart problems. They also have substantial financial burdens through multiple attendances at doctors' rooms and through restricted employment opportunities. Only just over one in four people with an anxiety disorder consults a health professional for their problems, with most going to their GP. It has been estimated that less than 10% of these people seek the services of a mental health specialist such as a clinical psychologist or psychiatrist. Therefore because of blocks to do with access, cost or embarrassment, many people with mental health problems do not seek face-to-face specialised mental health treatment. People in rural and regional Australia are particularly disadvantaged by limited access to these specialists. We have developed an internet-based treatment program on panic and anxiety for people in the community, and particularly in regional Australia. Early evaluation of this program has found it is more effective than other types of therapist-assisted self-help treatment. The aim of this research project is to compare it to best-practice face-to-face psychological and pharmacological treatment for PD. If the effectiveness of our internet-based treatment is comparable to best-practice face-to-face treatment, its availability will assist the many Australians who suffer from debilitating panic but who are unable to access specialised mental health assistance.Read moreRead less
Panic Disorder: Neurobiology And Mechanisms Of Cardiac Risk
Funder
National Health and Medical Research Council
Funding Amount
$456,657.00
Summary
Some people are subject to episodes of recurring, often inexplicable anxiety which are very unpleasant and accompanied by physical symptoms such as sweating, palpitations, tremor and a sensation of suffocation. Recurring attacks over a period of months, or years, forms the basis for the diagnostic of panic disorder. It has until recently been felt that although panic disorder was distressing and disabling, it did not constitute a risk of life. Sufferers often fear that they have heart disease, b ....Some people are subject to episodes of recurring, often inexplicable anxiety which are very unpleasant and accompanied by physical symptoms such as sweating, palpitations, tremor and a sensation of suffocation. Recurring attacks over a period of months, or years, forms the basis for the diagnostic of panic disorder. It has until recently been felt that although panic disorder was distressing and disabling, it did not constitute a risk of life. Sufferers often fear that they have heart disease, because of the nature of their symptoms, but have been reassured that this is not the case. Recent epidemiological studies, however, indicate that there is an increased risk in patients with panic disorder. Our hypotheses in this research project are as follow: That some specific genes predispose to the development of panic disorder - through actions on the nervous system and blood vessels That drug treatment (selective serotonin uptake blockers) and psychological treatment (cognitive behaviour therapy, CBT) reduce cardiac risk in panic disorder We will test these hypothesis using state of the art clinical scientific methods. Panic disorder has an important cardiological dimension which needs to be better understood for cardiac protection to be achieved in panic disorder patients.Read moreRead less
Panic Disorder: Neurobiology And Mechanisms Of Cardiac Risks
Funder
National Health and Medical Research Council
Funding Amount
$414,375.00
Summary
Some people are subject to episodes of recurring, often inexplicable anxiety which are very unpleasant and accompanied by physical symptoms such as sweating, palpitations, tremor and a sensation of suffocation. Recurring attacks over a period of months, or years, forms the basis for the diagnosis of panic disorder. It has until recently been felt that although panic disorder was distressing and disabling, it did not constitute a risk to life. Sufferers often fear that they have heart disease, be ....Some people are subject to episodes of recurring, often inexplicable anxiety which are very unpleasant and accompanied by physical symptoms such as sweating, palpitations, tremor and a sensation of suffocation. Recurring attacks over a period of months, or years, forms the basis for the diagnosis of panic disorder. It has until recently been felt that although panic disorder was distressing and disabling, it did not constitute a risk to life. Sufferers often fear that they have heart disease, because of the nature of their symptoms, but have been reassured that this is not the case. Recent epidemiological studies, however, indicate that there is an increased risk of heart risk in patients with panic disorder. Our hypotheses in this research are as follows: That panic disorder is characterised by increased release of the brain chemical messenger, serotonin, which is reversed by drug treatment with the most widely used class of drugs for this disorder, selective serotonin reuptake blockers That changes in an automatic stimulatory part of the nervous system, has primary importance in the disorder, in both genetically predisposing to panic disorder, and in mediating heart risk. That weight gain during therapy, a very common problem, is due to inhibition of brain serotonin release. We will test all these propositions using state of the art clinical scientific methods. Panic disorder has an important cardiological dimension which needs to be better understood for cardiac protection to be achieved in panic disorder patients. Our study of the mechanisms of cardiac risk should provide this. We will also provide very direct, valid measurements of chemical messenger release in the brain of panic disorder sufferers, using our unique methods. These should give a new understanding of the brain chemistry abnormalities of panic disorder, and the mechanism of action of the selective serotonin reuptake inhibitors.Read moreRead less