Does Palliative Chemotherapy Palliate? Measuring Symptom Benefit In Recurrent Ovarian Cancer Using Patient Reported Outcomes: The Symptom Benefit Study
Funder
National Health and Medical Research Council
Funding Amount
$405,024.00
Summary
Clinical trials for women with recurrent ovarian cancer traditionally use a reduction in tumour size and time to progression to measure the benefit of chemotherapy, but do not document whether women have symptom improvement as well. The aim of the Symptom Benefit Study is to validate an instrument that will allow patients to report their symptoms and degree of improvement and for the first time allow clinical trials to include a measure of symptom improvement when new drugs are being tested.
A Multi-site Randomised Controlled Trial Comparing The Severity Of Constipation Symptoms Experienced By Palliative Care Patients Receiving Usual Care Compared To Those Diagnosed And Managed According To The Underlying Pathophysiology.
Funder
National Health and Medical Research Council
Funding Amount
$498,795.00
Summary
This research aims to consider whether the problems of constipation in palliative care are less severe when the physical changes that underlie the problem are explored.
A Double-blind Randomised Controlled Multi-site Study Of Sertraline Compared With Placebo For Refractory Breathlessness
Funder
National Health and Medical Research Council
Funding Amount
$603,517.00
Summary
People with optimally treated emphysema often have breathlessness at rest or with little effort (dressing, preparing a meal). No medications are registered to reduce this breathlessness. This 3 year project will study whether a commonly used anti-depressant, sertraline, can reduce this breathlessness even if people are not depressed. Across Australia, 150 people will take part for at least 4 weeks to rate the unpleasantness of their breathlessness on sertraline or an identical sugar tablet.
A Randomised Controlled Trial Of Aetiology Based Antiemetic Guidelines For Reducing Nausea In Advanced Cancer Patients.
Funder
National Health and Medical Research Council
Funding Amount
$1,152,116.00
Summary
Nausea is a problem that can be very distressing to patients, and one that is difficult to assess and manage in patients with advanced cancer due to its multiple potential causes for this group. This study aims to test the effectiveness of an intervention which uses available anti-nausea medication specifically targeted to the likely cause of nausea for that individual to reduce the severity and impact of the symptom. It also tests second line medicatioins where nausea is unrelieved.
Use Of Emergency Departments By Vulnerable Groups During Their Last Year Of Life
Funder
National Health and Medical Research Council
Summary
Vulnerable people in their last year of life who attend Emergency Departments (EDs) could often be better cared for elsewhere. Our severely overcrowded EDs, and the staff who work in them, are poorly equipped to provide appropriate end-of-life care. This research describes how these groups use the ED, the impact of this use upon ED services and how the provision of adequate community care may be a more appropriate and economically viable option for people at the end-of-life.
Advance Care Planning In Incurable Cancer Patients With Disease Progression On First Line Chemotherapy: A Randomised Trial.
Funder
National Health and Medical Research Council
Funding Amount
$745,946.00
Summary
Advance care planning informs patient and care giver about end of life care options and assists patients to reflect on their goals, values and beliefs and to discuss and document their future choices. This randomised trial evaluates advance care planning in incurable cancer patients. The primary endpoint is the family member's view of the quality of death and compliance with known end of life wishes of the deceased patient. The costs of subsequent care are also recorded.
Reducing Demand On Emergency Departments In The Last Year Of Life
Funder
National Health and Medical Research Council
Funding Amount
$371,049.00
Summary
People in their last year of life who attend emergency departments (EDs) could often be better cared for elsewhere. Our severely overcrowded EDs, and the staff who work in them, are poorly equipped to provide appropriate end-of-life care. This research describes how people in their last year of life use EDs, the impact of this use upon ED services and how the provision of adequate primary care and supportive care services in the community care may be a more appropriate and economically viable op ....People in their last year of life who attend emergency departments (EDs) could often be better cared for elsewhere. Our severely overcrowded EDs, and the staff who work in them, are poorly equipped to provide appropriate end-of-life care. This research describes how people in their last year of life use EDs, the impact of this use upon ED services and how the provision of adequate primary care and supportive care services in the community care may be a more appropriate and economically viable option for people at the end-of-life.Read moreRead less