Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes. Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polyme ....Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes. Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polymer particle the drug carrier can specifically be recognized by cell receptors, thus allowing a targeted delivery of the drug to the desired area in the body. A range of carbohydrate-based drug carriers will be synthesized and tested towards their interaction with hepatocytes to allow optimisation of this drug carrier system.
Read moreRead less
Core-shell nanoparticle from polymers with pendant cyclodextrins. A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which will increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the explora ....Core-shell nanoparticle from polymers with pendant cyclodextrins. A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which will increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the exploration of synthetic routes to generate nanoparticles. Tailoring the underpinning polymer structure of these nanoparticles will allow the optimisation of the release of albendazole from the drug carrier, thus improving cancer treatment.Read moreRead less
Platinum drugs containing core-shell nanoparticles. Many drugs such as cancer drugs contain metal ions. While the therapeutic benefits of metal containing drugs are highly promising, their administration is often accompanied by substantial side effects. Encapsulation of these drugs into nano-sized core-shell particles will prolong the circulation of the drug and therefore reduce the amount of repeated administrations. In addition, the shape and nature of the particle will enable the targeted del ....Platinum drugs containing core-shell nanoparticles. Many drugs such as cancer drugs contain metal ions. While the therapeutic benefits of metal containing drugs are highly promising, their administration is often accompanied by substantial side effects. Encapsulation of these drugs into nano-sized core-shell particles will prolong the circulation of the drug and therefore reduce the amount of repeated administrations. In addition, the shape and nature of the particle will enable the targeted delivery of these drug loaded nanocarriers to the tumor while healthy tissue remains unaffected. Read moreRead less
Triggering the release of polymer bound platinum drugs. Platinum drugs are found to be highly efficient as anti-cancer drugs. Their side-effects however, limit their application. Nanoparticles are developed that bind the platinum drug tightly as long as the drug circulates in the blood stream, but releases the drug as soon as it reaches the tumour. To treat prostate cancer, the nanoparticle will be attached to a targeting moiety - a monoclonal antibody - that facilitates the effective delivery t ....Triggering the release of polymer bound platinum drugs. Platinum drugs are found to be highly efficient as anti-cancer drugs. Their side-effects however, limit their application. Nanoparticles are developed that bind the platinum drug tightly as long as the drug circulates in the blood stream, but releases the drug as soon as it reaches the tumour. To treat prostate cancer, the nanoparticle will be attached to a targeting moiety - a monoclonal antibody - that facilitates the effective delivery to the prostate cancer cells, but leaves healthy cells unaffected. This proposal aims to develop suitable synthetic pathway to enhance the treatment of cancer by using appropriate delivery vehicles. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561157
Funder
Australian Research Council
Funding Amount
$110,000.00
Summary
Multi-functional fluorescence microscopy laboratory. We have proposed a multipurpose fluorescent microscopy facility coupled to the RMIT microfabrication facility primarily for the study of the processes that make up lab-on-a-chip systems (the miniaturisation of a laboratory full of equipment to fit onto a credit card sized chip). Specifically the heart of the equipment, the variable wavelength pulsed laser coupled to an inverted microscope, will allow the study of temperature and fluid flow i ....Multi-functional fluorescence microscopy laboratory. We have proposed a multipurpose fluorescent microscopy facility coupled to the RMIT microfabrication facility primarily for the study of the processes that make up lab-on-a-chip systems (the miniaturisation of a laboratory full of equipment to fit onto a credit card sized chip). Specifically the heart of the equipment, the variable wavelength pulsed laser coupled to an inverted microscope, will allow the study of temperature and fluid flow in microchannels, the development of new electro-optic components, direct visualisation of electromagnetic radiation and its effect on cells, and the coupling of electrical and optical stimulation and sensing devices to microfluidic channels. Read moreRead less