Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously gen ....Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously generate nitric oxide, but not for extended periods of time. This project’s approach is significant because it avoids bacterial resistance to the nitric oxide treatment. Applications of this technology may include removing biofilms from environments such as water filtration devices and consumable medical surfaces.Read moreRead less
New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules fo ....New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules for agricultural, pharmaceutical and veterinary applications. The project is expected to develop a new suite of materials that could ultimately be used to improve the yield of important commercial crops, or revitalise the use of medicines limited by their poor side effect profile.Read moreRead less
A Novel Approach to Polymer/Nanosheet Composites and Their Fundamentals. Multifunctional Polymer/nanosheet composites have not yet been widely scaled up in polymer processing and composite industries mainly due to cost and inhaling hazard. This project proposes a novel methodology which embeds nanosheet preparation within polymer melt to both remove the inhaling hazard and lower the cost; the key is to develop two groups of nanosheet intercalation compounds which can expand at the polymer proces ....A Novel Approach to Polymer/Nanosheet Composites and Their Fundamentals. Multifunctional Polymer/nanosheet composites have not yet been widely scaled up in polymer processing and composite industries mainly due to cost and inhaling hazard. This project proposes a novel methodology which embeds nanosheet preparation within polymer melt to both remove the inhaling hazard and lower the cost; the key is to develop two groups of nanosheet intercalation compounds which can expand at the polymer processing temperature, to exfoliate and disperse nanosheets in polymers. It is expected to generate new knowledge of the structure-property relationships and fracture mechanisms of these composites, for industry to scale up this technology and to develop new product.Read moreRead less
Expanding the toolbox of synthetic stealth polymers. This project aims to develop a new generation of synthetic and biomimetic pseudo peptide polymers with advanced biomedical properties. The polymers will be used for the fabrication of a range of nanoparticles, which will allow to study the effect of architecture, composition and surface functionalisation on their behaviour in a biological environment. Carefully conducted structure-physicochemical property relationship and bio-nano interaction ....Expanding the toolbox of synthetic stealth polymers. This project aims to develop a new generation of synthetic and biomimetic pseudo peptide polymers with advanced biomedical properties. The polymers will be used for the fabrication of a range of nanoparticles, which will allow to study the effect of architecture, composition and surface functionalisation on their behaviour in a biological environment. Carefully conducted structure-physicochemical property relationship and bio-nano interaction studies will generate new knowledge in the area of stealth and protein repellent nanomaterials. The intended outcome of the project is the generation of a platform of bioinert materials that could potentially find applications as building blocks in next generation nanomedicines and medical devices.Read moreRead less
Nanoporous siloxane membranes for ultrasound mediated ophthalmic drug delivery. This project will develop tailored polymers for use in a novel non-invasive ocular drug delivery device which treats vision threatening conditions such as age-related macular degeneration (AMD). The outcomes of this project will enable an entirely new ocular drug delivery technology, thereby delivering significant benefit to ophthalmic healthcare.
Chiral synthetic macromolecules - control of sequence and stereochemistry. This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optim ....Chiral synthetic macromolecules - control of sequence and stereochemistry. This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optimised through the selective modification of polymer structure. These materials should be able to emulate the unique properties and functionality of natural peptides/proteins, making them invaluable for biochemical applications, such as molecular recognition and asymmetric catalysis.Read moreRead less
Conducting coatings for control and eradication of unwanted marine biofilms. Biofilms grow on all surfaces and environments posing environmental threats and economic issues globally, costing billions each year to those attempting to eradicate them. To date, biofilm's detailed response to variations in electrochemically generated redox stress and shear is unknown in marine environments. The project aims at (i) developing novel electrically conducting carbon based paints that are stable in marine ....Conducting coatings for control and eradication of unwanted marine biofilms. Biofilms grow on all surfaces and environments posing environmental threats and economic issues globally, costing billions each year to those attempting to eradicate them. To date, biofilm's detailed response to variations in electrochemically generated redox stress and shear is unknown in marine environments. The project aims at (i) developing novel electrically conducting carbon based paints that are stable in marine environments and (ii) investigating how marine biofilms respond to these coatings. The expected outcome of this project is the development of a green alternative antifouling technology that can be used on demand in marine applications. This provides a new solution for controlling the biofouling of surfaces immersed in oceans.Read moreRead less