Biomolecular activity modulated by interaction with nanostructures. Nanotechnological methods are able to reliably fabricate artificial nanostructures with dimensions similar to those of large biomolecules (a few to tens of nanometers). This study focuses on the interaction of artificial nanostructures with biomolecules such as proteins and DNA, and will enable scientists to better understand biomolecular recognition and binding events, which are central to all biological processes. The underst ....Biomolecular activity modulated by interaction with nanostructures. Nanotechnological methods are able to reliably fabricate artificial nanostructures with dimensions similar to those of large biomolecules (a few to tens of nanometers). This study focuses on the interaction of artificial nanostructures with biomolecules such as proteins and DNA, and will enable scientists to better understand biomolecular recognition and binding events, which are central to all biological processes. The understanding gained can then be used to design biomimetic surfaces for use in health monitoring and medical diagnostic devices with improved sensitivity, robustness and portability, thereby providing significant benefits to the health sector.Read moreRead less
Micro-patterning of fluoropolymer surfaces for electronic and biomaterials applications. Formation of micro-patterned structures on fluoropolymers including PTFE, FEP and PVDF will be performed using micro-contact printing techniques in combination with surface graft co-polymerisation; an innovative convergence of two emerging technologies. Surface modification and structures formed will be investigated using contact angle measurements and mapping, and surface analytical techniques (XPS and TOFS ....Micro-patterning of fluoropolymer surfaces for electronic and biomaterials applications. Formation of micro-patterned structures on fluoropolymers including PTFE, FEP and PVDF will be performed using micro-contact printing techniques in combination with surface graft co-polymerisation; an innovative convergence of two emerging technologies. Surface modification and structures formed will be investigated using contact angle measurements and mapping, and surface analytical techniques (XPS and TOFSIMS). Processing methodologies will be identified which allow formation of micrometre scale tracks, and selected area deposition of sensor films and reactive biomaterials. Trial device fabrication will be undertaken using conditions and device structures similar to those required for production of diagnostic sensors and arrays, and polymer-based electronic devices.Read moreRead less