Designed Delivery - Novel Hydrogels for Drug Delivery from Precisely-Structured Networks. This project will lead to the development of new biodegradable biomaterials ideally suited to many applications in drug delivery and tissue engineering. The understanding of their properties will be built on comprehensive models for diffusion of molecules through the material. The availability of these new biomaterials will facilitate future developments in drug delivery, and will ultimately lead to improve ....Designed Delivery - Novel Hydrogels for Drug Delivery from Precisely-Structured Networks. This project will lead to the development of new biodegradable biomaterials ideally suited to many applications in drug delivery and tissue engineering. The understanding of their properties will be built on comprehensive models for diffusion of molecules through the material. The availability of these new biomaterials will facilitate future developments in drug delivery, and will ultimately lead to improved medical outcomes in many areas such as tissue and bone regeneration. The materials designed in this project will help position the Australian biotechnology and pharmaceutical industries to take advantage of the more than $100B USD market (US alone; growth ~ 10% p.a.) in drug delivery.Read moreRead less
Formation and stability of polymerically stabilized colloids. This project will bring economic, medical and environmental benefits, with improved product performance and manufacturing processes for everyday industrial items relevant to a large industrial sector with significant employment in Australia: inks and paints (for example, surface coatings that can be applied more rapidly without clogging the jets); better means of preventing the fouling of industrial membranes; and improved materials f ....Formation and stability of polymerically stabilized colloids. This project will bring economic, medical and environmental benefits, with improved product performance and manufacturing processes for everyday industrial items relevant to a large industrial sector with significant employment in Australia: inks and paints (for example, surface coatings that can be applied more rapidly without clogging the jets); better means of preventing the fouling of industrial membranes; and improved materials for biomedical applications, with more desirable interactions between living cells and body fluids. These advances will also speed the replacement of solvent-based lacquer paints - detrimental to both environment and user - with water-based products of high quality.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347346
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Electrochemical Atomic Force Microscope and Nano-Manipulation Facility. This new Facility will add the nano-dimension to the excellent electrochemical mapping facility established at the University of Wollongong over the past 2 years. The instrument we propose to install will allow us to probe electrochemical events and, in particular, the influence of these events on the structure of customised materials at the nano level. This new capability will impact on our research into the development o ....Electrochemical Atomic Force Microscope and Nano-Manipulation Facility. This new Facility will add the nano-dimension to the excellent electrochemical mapping facility established at the University of Wollongong over the past 2 years. The instrument we propose to install will allow us to probe electrochemical events and, in particular, the influence of these events on the structure of customised materials at the nano level. This new capability will impact on our research into the development of efficient artificial muscles, biosensors, corrosion protection coatings, polymeric photovoltaics and new surfaces for mammalian cell culturing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453637
Funder
Australian Research Council
Funding Amount
$256,804.00
Summary
Multi-dimensional polymer characterization facility. The microstructure of polymers dominates their physical properties. This integrated facility will create a world-leading means of characterizing in multiple dimensions the microstructure of complex polymers, eg copolymers and branched polymers. The facility will yield information on the distributions of chain end-groups, monomer microstructure, and branches, as functions of molecular weight. The facility will provide otherwise unobtainable dat ....Multi-dimensional polymer characterization facility. The microstructure of polymers dominates their physical properties. This integrated facility will create a world-leading means of characterizing in multiple dimensions the microstructure of complex polymers, eg copolymers and branched polymers. The facility will yield information on the distributions of chain end-groups, monomer microstructure, and branches, as functions of molecular weight. The facility will provide otherwise unobtainable data for a set of projects exploring questions ranging from how new synthetic materials with tailor-made properties can be created, through to how our understanding of natural polymers can be advanced to improve crop utilization.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560981
Funder
Australian Research Council
Funding Amount
$160,940.00
Summary
Confronting the Challenges in Modern Spectroscopy of Polymers. Polymers and nanocomposites are increasingly being used in new, high value applications as diverse as medicine, structural engineering, optics and electronics. In order to control and understand polymer performance, a detailed knowledge of the chemical structure at all stages in their lifecycle is required - in the liquid, rubber and solid states and during degradation. This application seeks to establish a coordinated Polymer Spectr ....Confronting the Challenges in Modern Spectroscopy of Polymers. Polymers and nanocomposites are increasingly being used in new, high value applications as diverse as medicine, structural engineering, optics and electronics. In order to control and understand polymer performance, a detailed knowledge of the chemical structure at all stages in their lifecycle is required - in the liquid, rubber and solid states and during degradation. This application seeks to establish a coordinated Polymer Spectroscopy Network using new forms of infrared and NMR spectroscopy to probe samples (usually of an non-planar geometry) in a range of configurations. These will be used simultaneously with other techniques such as rheology or thermogravimetry, and will produce capabilities unique in Australia.Read moreRead less
Engineered Polymer Scaffolds for Controlled Proliferation and Differentiation of Stem Cells. This project aims to develop a new methodology to sculpt 3D polymer scaffolds coated with cell adhesion and growth factors to control environmental cues, for the first time rapidly generating large quantities of undifferentiated stem cells. This project aims to exponentially increase cell generation in order to finally be able to unlock the potential of stem cells for application in regenerative medicine ....Engineered Polymer Scaffolds for Controlled Proliferation and Differentiation of Stem Cells. This project aims to develop a new methodology to sculpt 3D polymer scaffolds coated with cell adhesion and growth factors to control environmental cues, for the first time rapidly generating large quantities of undifferentiated stem cells. This project aims to exponentially increase cell generation in order to finally be able to unlock the potential of stem cells for application in regenerative medicine. The resulting cell repositories could make a significant contribution to human health outcomes.Read moreRead less
A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures w ....A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures with unique property control and resolution, benefitting diverse fields ranging from designer (stem) cell niches and lab-on-a-chip applications to photonic wire bonding.Read moreRead less
Special Research Initiatives - Grant ID: SR0354805
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Research Network for Rehabilitation of Structures Using Advanced Materials and Frontier Technologies. There is an urgent need to rehabilitate existing structures that are considered inadequate in strength and serviceability. Frontier strengthening technologies (such as external post-tensioning and plate bonding) using conventional and advanced materials are being currently developed in Australia by different groups, but as yet not in a coordinated manner. The aim of this network is to bring tog ....Research Network for Rehabilitation of Structures Using Advanced Materials and Frontier Technologies. There is an urgent need to rehabilitate existing structures that are considered inadequate in strength and serviceability. Frontier strengthening technologies (such as external post-tensioning and plate bonding) using conventional and advanced materials are being currently developed in Australia by different groups, but as yet not in a coordinated manner. The aim of this network is to bring together a multi-disciplinary team with complementary strengths to provide an integrated solution for rehabilitation of structures. The core of the network focuses on design tools, linking the various technologies to provide appropriate rehabilitation and understanding of life cycle demands for major infrastructure.Read moreRead less
Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is a ....Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is applicable to polymerization kinetics studies, as well as providing new means for the determination of materials lifetimes. The development of pro-fluorescent markers as indicators for polymer degradation would be a significant outcome for materials where component failure has a major negative impact.Read moreRead less
Mechanistic investigation of fluorinated coatings for stone preservation. We will investigate mechanisms governing the synthesis of a latex used for stone preservation. This latex is made from novel and unusual starting materials, and will be the most complex system for which mechanisms have been investigated. We will redesign the synthesis procedure to control particle size and composition of the functional species at the particle surface. This will enable both particle size and surface composi ....Mechanistic investigation of fluorinated coatings for stone preservation. We will investigate mechanisms governing the synthesis of a latex used for stone preservation. This latex is made from novel and unusual starting materials, and will be the most complex system for which mechanisms have been investigated. We will redesign the synthesis procedure to control particle size and composition of the functional species at the particle surface. This will enable both particle size and surface composition to be tailored as desired. The results will be used to investigate the influence of these quantities on interactions between particles and sandstone surfaces. The outcomes will be used by the industrial partner to devise improved protective coatings for stone surfaces in Australian conditions.Read moreRead less