A Randomised Clinical Trial To Test A Pain Education Program For Patients With Cancer And Their Family Carers
Funder
National Health and Medical Research Council
Funding Amount
$150,000.00
Summary
This study seeks to improve cancer patients' and family carers' knowledge and attitudes toward pain management. A pain education program will be offered to patients with recurrent or progressive cancer and their primary family carers. The study addresses a palliative care concern that impacts upon a large number of Australians each year. The study has the potential to provide a brief, standardised protocol that could be taught and integrated into usual practice and to reduce health care costs fo ....This study seeks to improve cancer patients' and family carers' knowledge and attitudes toward pain management. A pain education program will be offered to patients with recurrent or progressive cancer and their primary family carers. The study addresses a palliative care concern that impacts upon a large number of Australians each year. The study has the potential to provide a brief, standardised protocol that could be taught and integrated into usual practice and to reduce health care costs for advanced cancer patients.Read moreRead less
Reduction Of Chronic Post-surgical Pain With Ketamine - ROCKet Study
Funder
National Health and Medical Research Council
Funding Amount
$4,823,395.00
Summary
Chronic post-surgical pain (CPSP) is a common complication of major surgery, and a significant burden on quality of life and ongoing health costs. Ketamine is a drug used by anaesthetists to treat severe acute surgical pain. Various small studies suggest that it may be unique in its ability to reduce the risk of CPSP. We propose a large trial of ketamine during & after anaesthesia for major surgery to test this. Demonstration of effectiveness would promote widespread change in clinical practice.
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Molecular Targets Of Amino Acid/neurotransmitter Conjugates Of Fatty Acids
Funder
National Health and Medical Research Council
Funding Amount
$846,390.00
Summary
This project investigates endogenous chemicals that affect cells important for detecting and responding to pain. We aim to discover how these compounds affect proteins important for nerve cell function, particularly proteins that have a prominent role in detecting and transmitting painful events. The compounds we examine are not themselves likely to be drugs, but future therapies may involve manipulating the levels of these chemicals in the body, or using drugs that mimic the activity of these c ....This project investigates endogenous chemicals that affect cells important for detecting and responding to pain. We aim to discover how these compounds affect proteins important for nerve cell function, particularly proteins that have a prominent role in detecting and transmitting painful events. The compounds we examine are not themselves likely to be drugs, but future therapies may involve manipulating the levels of these chemicals in the body, or using drugs that mimic the activity of these compounds.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
Use Of Analgesics To Reduce Agitation And Agression In Older Persons With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$552,556.00
Summary
Understanding the causes of Behavioural and Psychological Symptoms of Dementia (BPSD) provides a potentially remedial target for interventions. The current study will undertake the first ever trial of analgesics to reduce the frequency of agitation/aggression and other BPSD. By completion we will have new insights into the relationship between pain and various sub-types of BPSD and robust evidence on the best class of analgesics to treat BPSD
Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimod ....Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimodal dataset generated by the project will be made publicly available to enhance research transparency and international collaboration. This should provide significant benefits, ultimately opening up ways to improve quality of life and wellbeing of the Australian population.
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Knowledge to enhance Science Teaching and Learning: Pursuing scholarship through explicitly enacting expert science teachers' pedagogical content knowledge. This research will enhance understandings of science teaching and learning allowing science teachers to share their knowledge in meaningful ways. In teacher preparation this will be particularly valuable by 'fast-tracking' learning about teaching science and minimize the process of the next generation of teachers feeling as though they are r ....Knowledge to enhance Science Teaching and Learning: Pursuing scholarship through explicitly enacting expert science teachers' pedagogical content knowledge. This research will enhance understandings of science teaching and learning allowing science teachers to share their knowledge in meaningful ways. In teacher preparation this will be particularly valuable by 'fast-tracking' learning about teaching science and minimize the process of the next generation of teachers feeling as though they are rediscovering that which is already known by experienced teachers of science. In articulating science teachers' knowledge, enhanced valuing their knowledge and skills of practice will occur. Such outcomes will place understanding of science teaching and learning at the forefront of teacher professionalism and positively impact work on professional standards in teaching.Read moreRead less
Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of ....Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of responding to the problems inherent in teaching science in the 21st century. By supporting and encouraging the creative and innovative ideas, concepts and approaches to quality science teaching and learning embedded in teachers' professional learning the development of the critical knowledge for challenging the status-quo will be advanced.Read moreRead less
Research capacity-building: the development of Australian PhD programs in national and emerging global contexts. PhD programs in universities are the principal means by which new researchers are prepared for work in the knowledge economy. This project develops a comprehensive coded database of every PhD awarded in Australia since the first programs in the 1940s. It the will study fourteen different PhD programs that have developed during this period in four universities. The project focuses on ....Research capacity-building: the development of Australian PhD programs in national and emerging global contexts. PhD programs in universities are the principal means by which new researchers are prepared for work in the knowledge economy. This project develops a comprehensive coded database of every PhD awarded in Australia since the first programs in the 1940s. It the will study fourteen different PhD programs that have developed during this period in four universities. The project focuses on how these programs develop research capacity within disciplines and how these are related to the changing social, cultural and economic needs of Australia. The project will assist in planning future PhD programs and research capacity development.Read moreRead less