The Analgesic Evaluation Of Novel Natural Products From The Australian Plant Barringtonia Acutangula
Funder
National Health and Medical Research Council
Funding Amount
$174,500.00
Summary
This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that wi ....This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that will allow for their pharmacological evaluation as potential analgesic drugs.Read moreRead less
Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre wil ....Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre will align highly successful clinical and basic researchers in collaboration with a national network of spine scientists to foster interdisciplinary clinical researcher training, develop new diagnostics and therapeutics, and translate findings to the community. Through clinical research the centre aims to: (i) Advance understanding of physiology and pathophysiology of spinal pain (ii) Translate findings from basic research to clinical practice (iii) Establish coordinated multidisciplinary research to reduce the burden of spinal pain (iv) Predict and prevent the transition from acute to chronic states (v) Train a new generation of transdisciplinary clinical scientists (vi) Rapidly assess new treatment possibilities in pre-clinical studies (vii) Develop innovative technologies for diagnostics and therapeutics (viii) Encourage Australian commercialisation opportunities for new discoveries (ix) Encourage community-user participation in direction of research programs (x) Disseminate new findings and information of evidence-based practice to patients, clinicians, insurers, government and the scientific and wider communityRead moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These f ....The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These findings will inform the current debate about the appropriate models of teacher education and the balance of emphasis on content knowledge and pedagogical knowledge. Secondly, given a number of attempts to attract mid career professionals with high qualifications to teaching, the study will provide evidence on how these people transition to their new careers and what support is needed.Read moreRead less
Physiotherapist Led Stress Inoculation Intervention Integrated With Exercise For Acute Whiplash Injury
Funder
National Health and Medical Research Council
Funding Amount
$518,960.00
Summary
Physical and mental health outcomes following whiplash injury due to a road traffic crash are poor. Early stress system responses are associated with poor recovery. This study will investigate the effectiveness of a physiotherapist led stress inoculation intervention integrated with currently recommended exercise rehabilitation to improve health outcomes after whiplash injury.
Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are droppi ....Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are dropping behind in international competitiveness in reading and literacy achievement. The study concentrates on early reading development and to inform on teacher education and classroom teaching practices. Read moreRead less
Researching Collective Argumentation in Mathematics and Science Classrooms. The project will provide evidence-based pedagogical strategies for the reform of classroom teaching and learning in the crucial areas of mathematics and science. We will develop a form of pedagogy (Collective Argumentation) that enables students to be confident in deploying mathematical and scientific knowledge and skills in relation to the economic and social choices that they make in everyday contexts. Collective Argum ....Researching Collective Argumentation in Mathematics and Science Classrooms. The project will provide evidence-based pedagogical strategies for the reform of classroom teaching and learning in the crucial areas of mathematics and science. We will develop a form of pedagogy (Collective Argumentation) that enables students to be confident in deploying mathematical and scientific knowledge and skills in relation to the economic and social choices that they make in everyday contexts. Collective Argumentation can induct students into 'habits of mind and social practices' necessary for building an innovative learning community. This project will enable us to extend this innovative approach and to further develop its effectiveness.Read moreRead less
Telling Tales from the Bush: Gender, rurality and post-school transitions. The completion of formal schooling is a critical point of decision-making for all young Australians, but it is particularly critical for young men and women from the bush, who are often already disadvantaged in the quality of schooling they receive, and their access to facilities and opportunities. This longitudinal study will address a significant research gap in this area, by analysing the potentially limiting effect g ....Telling Tales from the Bush: Gender, rurality and post-school transitions. The completion of formal schooling is a critical point of decision-making for all young Australians, but it is particularly critical for young men and women from the bush, who are often already disadvantaged in the quality of schooling they receive, and their access to facilities and opportunities. This longitudinal study will address a significant research gap in this area, by analysing the potentially limiting effect gender constructs can play in the decision-making and life trajectories of these young adults. By so doing, the study contributes directly to the national interest by improving the social and economic futures of rural Australians.Read moreRead less
Emotional Transitions: Exploring Professional Transitions of Science Teachers. Research most needed to inform policy and practice for improving teacher education and the retention of new-science teachers is that which captures the experiences and development of the new teacher, particularly in the critical transition period from university to full-time work in schools. This period is fundamental to becoming a satisfied and effective teacher. Our study contributes significantly to national concer ....Emotional Transitions: Exploring Professional Transitions of Science Teachers. Research most needed to inform policy and practice for improving teacher education and the retention of new-science teachers is that which captures the experiences and development of the new teacher, particularly in the critical transition period from university to full-time work in schools. This period is fundamental to becoming a satisfied and effective teacher. Our study contributes significantly to national concerns for quality-teacher education by providing new insights into the emotions and identities of transitioning-science teachers in practice. The proposed study also models innovative procedures that can enrich subsequent longitudinal studies of teacher transitions and impact of teacher-education programs.Read moreRead less
Crisis in chemistry: How do we best teach particle concepts for understanding? Fundamental chemistry knowledge is essential in the information age because citizens and professionals need to make informed decisions about GM technology, pollution and how to teach science. Chemistry learning is compromised by recurring intuitive and taught misconceptions about atoms and molecules. The widely documented misconceptions emphasise what students cannot do. This unique project studies students, teachers ....Crisis in chemistry: How do we best teach particle concepts for understanding? Fundamental chemistry knowledge is essential in the information age because citizens and professionals need to make informed decisions about GM technology, pollution and how to teach science. Chemistry learning is compromised by recurring intuitive and taught misconceptions about atoms and molecules. The widely documented misconceptions emphasise what students cannot do. This unique project studies students, teachers and international chemistry educators to develop a theoretical and practical model of what students can understand and do in primary, secondary and university chemistry with respect to atoms and molecules. The research will significantly improve chemistry teaching at the macroscopic, microscopic and symbolic levels.Read moreRead less