Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Employee wellbeing and productivity: the role of territoriality, conflict and emotions. Australia is investing billions in redesigning modern office spaces, but the effect of office layout on employees is still not well understood. Using innovative real-time data collection techniques, an international team will study the effect of office layout and develop a training package to improve office-worker productivity and wellbeing.
Development of psychological capital in emergency service organisations. The project addresses the research priorities ‘Promoting good health and well being for all Australians’ and Safeguarding Australia. The project will identify ways in which the performance and wellbeing of volunteer and paid members of emergency service organisations can be enhanced, potentially diminishing the likelihood of depression, aggression, and other detrimental effects. The findings will also contribute to the qual ....Development of psychological capital in emergency service organisations. The project addresses the research priorities ‘Promoting good health and well being for all Australians’ and Safeguarding Australia. The project will identify ways in which the performance and wellbeing of volunteer and paid members of emergency service organisations can be enhanced, potentially diminishing the likelihood of depression, aggression, and other detrimental effects. The findings will also contribute to the quality of training provided to leaders in emergency services. Theoretically, the project will advance understanding of the mechanisms that underpin the psychological capital construct, placing Australian researchers at the forefront of this important emerging field of inquiry.Read moreRead less
Maximising the value of alliances in delivering infrastructure projects: a mixed methods management study of procurement innovation. Australia’s new infrastructure is currently being delivered inefficiently. The project will take a novel approach to improving efficiency, focusing on cooperation within construction teams. The project will develop new mechanisms to align incentives and capabilities within construction teams.
Building capacity for adaptive management in protected areas through improved systems for monitoring and evaluation. The project demonstrates how evaluation can lead to improved management of protected areas. Effectively managed protected areas are essential for biodiversity conservation. Improved management, and hence improved conservation outcomes will flow from enhanced use of monitoring and evaluation data in decision-making. Identifying strengths and weaknesses in management will allow mana ....Building capacity for adaptive management in protected areas through improved systems for monitoring and evaluation. The project demonstrates how evaluation can lead to improved management of protected areas. Effectively managed protected areas are essential for biodiversity conservation. Improved management, and hence improved conservation outcomes will flow from enhanced use of monitoring and evaluation data in decision-making. Identifying strengths and weaknesses in management will allow managers to better allocate resource for more effective conservation outcomes. The project establishes connections with all protected area management agencies in Australia, and will contribute to the development of national policy and practice in protected area evaluation and reporting, thus helping to meet national and international reporting obligations. Read moreRead less
Nitrous oxide and methane emissions from South East Queensland waterways and influence of wastewater discharges. Climate change caused by greenhouse gas emissions is one of the most serious challenges facing mankind. Substantial emission reduction must be achieved, with responsibilities to be shared by all sectors. Rivers, estuaries and water storages contribute considerably to global nitrous oxide and methane emissions, much of which is anthropogenic contributed by urban and agricultural run-of ....Nitrous oxide and methane emissions from South East Queensland waterways and influence of wastewater discharges. Climate change caused by greenhouse gas emissions is one of the most serious challenges facing mankind. Substantial emission reduction must be achieved, with responsibilities to be shared by all sectors. Rivers, estuaries and water storages contribute considerably to global nitrous oxide and methane emissions, much of which is anthropogenic contributed by urban and agricultural run-off and wastewater discharges. Through an in-depth study on several rivers, estuaries and reservoirs in South East Queensland, this project will provide data to enable reliable estimation of such emissions in Australia, and deliver knowledge and tool support for the development of strategic catchment management strategies.Read moreRead less
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Serving the greater good: using 'Servant Leadership' to build ethical and engaging work practices. The project will result in the first organisational application in Australia of a leadership development program based on scientific foundations of the 'Servant Leadership' framework. The outcomes will benefit organisations of all types in developing the leadership capabilities required to create ethical, positive, and sustainable work environments.
Improved monitoring of aquatic pollutants in national water resources. Clean water is predicted to become the world’s most valuable asset during this century, necessitating the improved monitoring of Australia’s limited water resources. Using a new and integrated monitoring approach, this project expects to develop and implement novel passive sampling technologies to monitor a range of water pollutants, specifically toxic ionised organic chemicals of emerging concern. The outcomes of this projec ....Improved monitoring of aquatic pollutants in national water resources. Clean water is predicted to become the world’s most valuable asset during this century, necessitating the improved monitoring of Australia’s limited water resources. Using a new and integrated monitoring approach, this project expects to develop and implement novel passive sampling technologies to monitor a range of water pollutants, specifically toxic ionised organic chemicals of emerging concern. The outcomes of this project will create cost-effective tools to advance the detection of emerging chemicals in drinking, ground, surface and waste waters. The technology will benefit millions of Australians by safeguarding essential water resources.Read moreRead less