Irritable Bowel Syndrome (IBS) is one of the leading causes of chronic pain both world-wide and in Australia for which there is a lack of treatments. Chronic pain arises from nerve fibres in the colon wall, which fail to 'reset' back to normal following inflammation. Targeting these nerve endings with drugs is a key advance in IBS treatment. This project will identify selective oxytocin analogues that act in the colon to lower pain in sensory nerves thus providing efficacious pain relief in IBS.
Improving Pain And Movement Outcomes In Symptomatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
People fear getting painful knee osteoarthritis (OA) more than any other disease – it is seen as progressive and incurable. It often stops people from moving and staying healthy, resulting in an enormous burden on sufferers and the health care system. This program of research aims to understand what brain & nervous system processes might underlie these pain and movement problems and whether new brain-targeting treatment helps. This will allow us to better match treatment to what patients need.
Interaction Of TRP Channels And Inflammatory Mediators: A Critical Role In Visceral Pain
Funder
National Health and Medical Research Council
Funding Amount
$308,747.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we feel, such as touch and pain. The function of these channels can be altered by substances released by the body during inflammation. Some TRP channels have specialized roles in signalling pain from the colon which can be enhanced during colonic inflammation. Understanding how TRP channels and inflammatory mediators function and interact is essential if we are to find treatments for colonic pain.
Ion Channels Underlying Inflammatory And Post-inflammatory Visceral Mechanical Hypersensitivity
Funder
National Health and Medical Research Council
Funding Amount
$453,439.00
Summary
Inflammation causes tissue damage that triggers ion channels within sensory nerve fibres to produce greater signals in response to mechanical events, causing acute pain. In chronic pain, although the inflamed tissue has healed, sensory nerve fibres fail to "reset" back to normal. Often chronic pain is more severe than acute pain. This project will identify which ion channels are responsible for signalling acute and chronic visceral pain, explaining why sensory nerve fibres fail to reset.
How Intestinal Motility Activates Sensory Pathways
Funder
National Health and Medical Research Council
Funding Amount
$555,875.00
Summary
Pain and discomfort from the gut are common and unpleasant. We understand how gut sensory nerve cells work, at the cellular, molecular and genetic level. However, movement of the gut wall and contents are the major cause of activation of sensory neurons. We know little about which particular patterns of movement cause pain. This is crucial information for accurately diagnosing human gut disorders, for monitoring effectiveness of treatments and for identifying potential new drug targets.
A Sequential Multiple Assignment Randomised Trial (SMART) Of Nursing Interventions To Reduce Pain Associated With Chemotherapy Induced Peripheral Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$713,418.00
Summary
Modern chemotherapy treatments can result in damage to the peripheral nerves, resulting in a condition called peripheral neuropathy. This condition is characterised by a range of sensory and functional changes that can cause pain and reduced ability to perform daily activities. This project will test various non-pharmacological pain management measures to determine if they are effective in improving the quality of life of patients who experience this problem.
Children of the new millennium: Using information and communication technologies for playing and learning in the information age. This research explores the development of young children's expertise with information and communication technologies from the preschool to the second year of school. It examines where young children in diverse socioeconomic areas use information and communication technologies, how many forms of it they use and to what extent technology relates to other forms of play ....Children of the new millennium: Using information and communication technologies for playing and learning in the information age. This research explores the development of young children's expertise with information and communication technologies from the preschool to the second year of school. It examines where young children in diverse socioeconomic areas use information and communication technologies, how many forms of it they use and to what extent technology relates to other forms of play and learning in literacy and numeracy. An assessment tool will be developed to explore how children's knowledge, understanding and use of technology changes over time. The research will inform policy and curriculum directions in the early years of education.Read moreRead less
Building the capabilities of school communities to improve their wellbeing. Wellbeing remains an issue for all education systems and for the nation. One indicator of this is that, on average, one in six Australian students experience affronts to their wellbeing through bullying or harassment at least once a week. Teacher wellbeing is also an issue of national importance as education systems face issues of teacher retention. This project will provide a model that can be used by other schools and ....Building the capabilities of school communities to improve their wellbeing. Wellbeing remains an issue for all education systems and for the nation. One indicator of this is that, on average, one in six Australian students experience affronts to their wellbeing through bullying or harassment at least once a week. Teacher wellbeing is also an issue of national importance as education systems face issues of teacher retention. This project will provide a model that can be used by other schools and educational systems for development of interventions that address wellbeing issues of social competence, learning and leadership for key groups in school communities. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100510
Funder
Australian Research Council
Funding Amount
$350,977.00
Summary
How first-in-family males transition to Australian university life. This project aims to study how gender, ethnicity and social class affect Australian males from low socio-economic backgrounds as they transition to university. Despite an emphasis on widening participation in the Australian university sector, the path to university is still precarious, particularly for first-in-family students. Males from low socio-economic backgrounds remain severely underrepresented in higher education, and ho ....How first-in-family males transition to Australian university life. This project aims to study how gender, ethnicity and social class affect Australian males from low socio-economic backgrounds as they transition to university. Despite an emphasis on widening participation in the Australian university sector, the path to university is still precarious, particularly for first-in-family students. Males from low socio-economic backgrounds remain severely underrepresented in higher education, and how these students experience university life is unclear. The project will use qualitative research to better understand the experiences of first-in-family males entering universities in different locales/institutions across Australia. Expected outcomes include improved targeted support systems to enable their success.Read moreRead less
Cyberkids and cyberworlds: new literacies, identities and communities in formation. Little is known of the online cyberworlds of young Australians. Yet they are the highest users of Information and Communications Technologies (ICTs). This project theorises that these cyberworlds are sites for the development of new forms of literacy, identity and community. This study will achieve a new perspective by utilising a multi-disciplinary approach to produce case studies that examine new literacies an ....Cyberkids and cyberworlds: new literacies, identities and communities in formation. Little is known of the online cyberworlds of young Australians. Yet they are the highest users of Information and Communications Technologies (ICTs). This project theorises that these cyberworlds are sites for the development of new forms of literacy, identity and community. This study will achieve a new perspective by utilising a multi-disciplinary approach to produce case studies that examine new literacies and communities generated online and their consequences for literacy and ICT education practice. Such information is vital in Australia and internationally if education is to produce the highly technologically literate citizens on whom future economic prosperity depends.Read moreRead less