Discovery Early Career Researcher Award - Grant ID: DE120100796
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Androgens and ovarian function. This innovative project aims to identify the role androgens play in the complex processes required for successful ovarian follicle development and ovulation. The project aims to identify androgen regulated pathways that orchestrate follicle development, which will have significance in the control of fertility and the advancement of reproductive technologies.
A novel microtubule severing protein involved in male germ cell biology. The project aims to better understand the cellular and biochemical mechanisms underlying a key component of male fertility. Microtubules are a fundamental component of all cells. A mechanism that is increasingly recognised as essential for microtubules regulation is severing. It has been discovered that an uncharacterised microtubule severing protein, KATNAL2, has a key role in male germ cell development. This project aims ....A novel microtubule severing protein involved in male germ cell biology. The project aims to better understand the cellular and biochemical mechanisms underlying a key component of male fertility. Microtubules are a fundamental component of all cells. A mechanism that is increasingly recognised as essential for microtubules regulation is severing. It has been discovered that an uncharacterised microtubule severing protein, KATNAL2, has a key role in male germ cell development. This project aims to define the mechanisms underlying KATNAL2 function in the male germ line. It is expected that these data will generate a comprehensive picture of KATNAL2 function and provide foundation data of relevance across multiple species and tissues. In the longer term, it may also reveal a rational strategy for fertility enhancement or suppression.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101449
Funder
Australian Research Council
Funding Amount
$463,399.00
Summary
How mammalian males indirectly control transmission of paternal traits. This project aims to address how environmental insults in males prior to conception are able to modify phenotype of subsequent offspring. This project expects to generate fundamental knowledge in a key biological pathway on how non-genetic factors delivered by sperm at conception are able to program the growth of the developing embryo.The knowledge generated from this project will provide understanding and biological options ....How mammalian males indirectly control transmission of paternal traits. This project aims to address how environmental insults in males prior to conception are able to modify phenotype of subsequent offspring. This project expects to generate fundamental knowledge in a key biological pathway on how non-genetic factors delivered by sperm at conception are able to program the growth of the developing embryo.The knowledge generated from this project will provide understanding and biological options for responding to, and potentially mitigating the impacts of environmental change on the mammalian reproductive system.Read moreRead less
Interactions between cells and extracellular matrix in the epithelial-mesenchymal transition of the ovarian follicular stratified epithelium. The lining of many mammalian organs and cavities contain cells that can transform into different cells to bring about organ development or repair but if it goes horribly wrong the cells become metastatic cancers. This project examines the key features of this process especially the roles of matrix that develops around the cells in this process.