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Molecular transistors: from strings and rings to other things. This project aims to use chemical approaches to develop molecular transistors, which are critical components for a future molecular electronics technology. The use of molecules as ultra-miniaturised electronic components is gathering attention from industry and academia, as a solution to the approaching limits of top-down scaling. However, current molecular designs based on gating through chemical reaction or redox state changes are ....Molecular transistors: from strings and rings to other things. This project aims to use chemical approaches to develop molecular transistors, which are critical components for a future molecular electronics technology. The use of molecules as ultra-miniaturised electronic components is gathering attention from industry and academia, as a solution to the approaching limits of top-down scaling. However, current molecular designs based on gating through chemical reaction or redox state changes are slow and inefficient. The project will develop molecular transistors with exceptionally high gain and fast response based on gating the energy of quantum interference features in molecules with cross-conjugated or ring-like shapes. This will provide significant benefits including new strategies for nanofabrication of molecular devices.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100985
Funder
Australian Research Council
Funding Amount
$427,116.00
Summary
Shining a Light on Brain Temperature with Near-Infrared Nanosensors. This project aims to develop a contactless thermometry approach based on near-infrared fluorescence to map brain or nerve temperature in real-time. This research expects to generate new knowledge in the field of neuroscience using tools from optics, nanotechnology and materials science. The technique generated as a result of this project is expected to enable the quantification of the transient local heating of the nervous syst ....Shining a Light on Brain Temperature with Near-Infrared Nanosensors. This project aims to develop a contactless thermometry approach based on near-infrared fluorescence to map brain or nerve temperature in real-time. This research expects to generate new knowledge in the field of neuroscience using tools from optics, nanotechnology and materials science. The technique generated as a result of this project is expected to enable the quantification of the transient local heating of the nervous system in different situations and the study of how this affects neural function. This is expected to provide significant benefits, enabling the development of regulatory frameworks that ensure the safe implementation of new therapies for neurological and neurodegenerative disorders.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100839
Funder
Australian Research Council
Funding Amount
$442,162.00
Summary
Nanoarchitectured platform technology for molecular profiling of exosomes. The aim of this project is to develop a set of cutting-edge nanotechnologies and a nanofabrication strategy to create a highly sensitive platform technology for exosome and exosomal miRNA analysis. This project aims to generate new knowledge in mesoporus nanomaterials and transudcer as well as exosome chemistry by developing nanostructure-based platform technology (device) for automated and rapid analysis. This project's ....Nanoarchitectured platform technology for molecular profiling of exosomes. The aim of this project is to develop a set of cutting-edge nanotechnologies and a nanofabrication strategy to create a highly sensitive platform technology for exosome and exosomal miRNA analysis. This project aims to generate new knowledge in mesoporus nanomaterials and transudcer as well as exosome chemistry by developing nanostructure-based platform technology (device) for automated and rapid analysis. This project's findings are expected to provide Australia with cutting-edge expertise for developing a next-generation platform technology for analysing exosomes and other relevant biomolecules, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Clay nanoparticle-facilitated RNAi for non-transgenic modification of crops. This project aims to define the most effective spray formulations, consisting of clay nanoparticles and induced RNA interference (RNAi) to manipulate gene expression in plants. Topical application of double-stranded RNA (dsRNA) for RNAi represents an attractive alternative to genetically engineered crops. However, naked dsRNA is unstable and is not efficiently taken up by plants. For these reasons, topical application o ....Clay nanoparticle-facilitated RNAi for non-transgenic modification of crops. This project aims to define the most effective spray formulations, consisting of clay nanoparticles and induced RNA interference (RNAi) to manipulate gene expression in plants. Topical application of double-stranded RNA (dsRNA) for RNAi represents an attractive alternative to genetically engineered crops. However, naked dsRNA is unstable and is not efficiently taken up by plants. For these reasons, topical application of dsRNA has thus far produced only modest induction of RNAi in plants. Nanoparticle-facilitated manipulation of gene expression in plants will enable sustainable clean green strategies for protecting crops from diseases. This project will result in improved crop protection and productivity and boost the export potential of Australian crops.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100279
Funder
Australian Research Council
Funding Amount
$424,198.00
Summary
A nanodiamond voltage sensor: towards real-time, long-term neuronal sensing. This project aims to develop a voltage sensor that may ultimately be used to measure neuronal signals noninvasively in real-time and over hours. The project expects to generate the fundamental science needed to use nanodiamonds for fluorescence-based voltage sensing that can be easily measured using optical microscopy. The expected outcome is a biocompatible sensor that should provide a solution to one of the biggest ch ....A nanodiamond voltage sensor: towards real-time, long-term neuronal sensing. This project aims to develop a voltage sensor that may ultimately be used to measure neuronal signals noninvasively in real-time and over hours. The project expects to generate the fundamental science needed to use nanodiamonds for fluorescence-based voltage sensing that can be easily measured using optical microscopy. The expected outcome is a biocompatible sensor that should provide a solution to one of the biggest challenges in neuroscience; the fast, precise and long-term measurement of neuronal activity. This technology may one day inform our understanding of how the normal brain works and provide major insights into mental health conditions and neurodegenerative diseases.Read moreRead less
Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interf ....Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interfaces. New fundamental discoveries will have an impact on technologies such as medical device coatings, biomaterials, biosensors, microfluidics devices, protein purification and diagnostics assays that are critically dependent on the biological function of adsorbed or immobilized proteins.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100076
Funder
Australian Research Council
Funding Amount
$367,446.00
Summary
Scalable synthesis of smart nanoworms with tailored properties. This project aims to develop next-generation nanomaterials that have a special worm-like shape and can intelligently respond to environmental signals. The project is expected to generate new knowledge in the area of advanced manufacturing utilising innovative approaches in nanotechnology and polymer chemistry. The anticipated outcome is an environmentally friendly technology for industrial production of high value-added nanomaterial ....Scalable synthesis of smart nanoworms with tailored properties. This project aims to develop next-generation nanomaterials that have a special worm-like shape and can intelligently respond to environmental signals. The project is expected to generate new knowledge in the area of advanced manufacturing utilising innovative approaches in nanotechnology and polymer chemistry. The anticipated outcome is an environmentally friendly technology for industrial production of high value-added nanomaterials that may ultimately have a variety of applications including, but not limited to, early diagnosis and efficient therapy of cancer. This should provide benefits to the Australian economy, environment and society.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100435
Funder
Australian Research Council
Funding Amount
$383,982.00
Summary
Photonic Crystal Sensors for Intelligent Packaging. This project aims to synthesize and investigate the properties of optical sensors composed of oriented assembled, high-flexible metal-organic-framework-based photonic crystals. This project is expected to generate new knowledge in the area of oriented self-assembly and elucidate the relationship between the optical properties of photonic crystal optical sensors and the orientation, flexibility and functionalisation of metal-organic frameworks. ....Photonic Crystal Sensors for Intelligent Packaging. This project aims to synthesize and investigate the properties of optical sensors composed of oriented assembled, high-flexible metal-organic-framework-based photonic crystals. This project is expected to generate new knowledge in the area of oriented self-assembly and elucidate the relationship between the optical properties of photonic crystal optical sensors and the orientation, flexibility and functionalisation of metal-organic frameworks. Expected outcomes of this project include novel oriented assembly methods and a series of optical sensing devices for various detection scenarios. This research will provide significant benefits on environmental protection, sustainable development, food safety and human health.Read moreRead less
Design of 2D Soft Plasmonic Photocatalysts for Artificial Leaves. The project aims to fabricate 2D soft plasmonic photocatalysts with leaf-like structures and functions for solar-to chemical energy conversions. The proposed 2D photocatalysts expect to change the traditional way of designing artificial photocatalysts. Expected outcomes of this project include fabrication of 2D soft plasmonic photocatalyst with large-area, ultrathin thickness, and high flexibility, understanding their plasmon-enha ....Design of 2D Soft Plasmonic Photocatalysts for Artificial Leaves. The project aims to fabricate 2D soft plasmonic photocatalysts with leaf-like structures and functions for solar-to chemical energy conversions. The proposed 2D photocatalysts expect to change the traditional way of designing artificial photocatalysts. Expected outcomes of this project include fabrication of 2D soft plasmonic photocatalyst with large-area, ultrathin thickness, and high flexibility, understanding their plasmon-enhanced photocatalysis mechanisms, and construction of artificial leaves to perform the solar-to-chemical conversions, which can provide significant benefits, such as creating new-generation of soft energy devices and advancing Australian expertise in photochemistry, self-assembly, and functional nanomaterials.Read moreRead less