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Roles Of PTHrP And Calcium In Mammary Function In Perinatal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$376,320.00
Summary
Babies that are born small have significant problems around the time of birth and may have limited catch-up growth. A recently discovered protein known as PTHrP influences the nutrition of the growing newborn through breast milk. Because of its potential importance to small babies we intend to study this protein during and after pregnancy in rats and their pups. New treatments may emerge from the knowledge gained from these studies that may improve the growth and health of infants.
ROLE OF EPHRIN-EPH SIGNALLING IN THE FORMATION PHASE OF BONE REMODELLING
Funder
National Health and Medical Research Council
Funding Amount
$538,459.00
Summary
Bone is constantly being renewed through bone remodelling. An amount of bone is removed by osteoclasts, and bone-forming osteoblasts make just enough to fill the space. We discovered that proteins known as ephrins are produced by osteoblasts, and act on neighbouring osteoblasts to help them make new bone. We aim to define how ephrins increase bone formation in remodelling, how that is controlled and how it might be used to find ways to increase bone formation.