Discovery and directed evolution of small molecule biosensors. This project aims to address the need for novel small molecule biosensing capability in diverse fields including food and wine production, environmental monitoring, biocatalysis, and diagnostics using a synthetic biology approach. The significance of this work is the development of new biosensors by a strong interdisciplinary team contributing bioinformatics to identify new biosensors, innovative protein engineering approaches, and c ....Discovery and directed evolution of small molecule biosensors. This project aims to address the need for novel small molecule biosensing capability in diverse fields including food and wine production, environmental monitoring, biocatalysis, and diagnostics using a synthetic biology approach. The significance of this work is the development of new biosensors by a strong interdisciplinary team contributing bioinformatics to identify new biosensors, innovative protein engineering approaches, and cutting-edge directed evolution methodologies. Intended outcomes include enhanced institutional capacity for interdisciplinary collaboration; discovery of fundamentally important bacterial sensors; and development of synthetic regulatory circuits enabling outgrowth of non-biological biocatalysis industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100133
Funder
Australian Research Council
Funding Amount
$657,987.00
Summary
An Open Access Native Mass Spectrometry Facility. This project aims to create a world-class Native Mass Spectrometry Facility to allow measurement of proteins, protein complexes and other biomolecules, in a way such that key structural information is maintained. This instrumentation will be the first of its type in Australia allowing measurement of very high mass ions with high precision and accuracy. A better understanding of protein structure will enable new discoveries in chemistry, biotechn ....An Open Access Native Mass Spectrometry Facility. This project aims to create a world-class Native Mass Spectrometry Facility to allow measurement of proteins, protein complexes and other biomolecules, in a way such that key structural information is maintained. This instrumentation will be the first of its type in Australia allowing measurement of very high mass ions with high precision and accuracy. A better understanding of protein structure will enable new discoveries in chemistry, biotechnology and medicinal research. Read moreRead less