A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures w ....A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures with unique property control and resolution, benefitting diverse fields ranging from designer (stem) cell niches and lab-on-a-chip applications to photonic wire bonding.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100014
Funder
Australian Research Council
Funding Amount
$3,275,680.00
Summary
Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromo ....Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromolecules to advanced functional photoresists for 3D laser lithography as well as materials that self-report structural transformations by light or are reprogrammable in their properties by photonic fields. Harnessing the power of light as a precision tool for the construction of advanced macromolecular materials will provide technology outcomes for Australian manufacturing industries from electronics to health. This includes laser-driven 3D printing technology at the nano-level, light-adaptive smart reprogrammable coatings and materials, synthetic proteins responsive to light as well as tailor-made single cell niches.Read moreRead less
Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polym ....Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polymer chain and the molecular weight distribution. The project will result in the preparation of functional polymers containing a specific arrangement of monomers in the polymer chain and a precise distribution of polymer chains. The development of such process will result in the development of advanced materials.Read moreRead less
New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules fo ....New materials for manipulating intracellular communication. This project aims to identify new techniques for incorporating cell-signalling triggers into macromolecules, therefore enabling the development of next-generation stimuli-responsive nanoparticles that can emit signalling molecules on demand. Harnessing nanomaterials to stimulate specific sub-cellular processes is a neglected area in nanotechnology research. These nanoparticles could potentially be used to deliver signalling molecules for agricultural, pharmaceutical and veterinary applications. The project is expected to develop a new suite of materials that could ultimately be used to improve the yield of important commercial crops, or revitalise the use of medicines limited by their poor side effect profile.Read moreRead less
Expanding the toolbox of synthetic stealth polymers. This project aims to develop a new generation of synthetic and biomimetic pseudo peptide polymers with advanced biomedical properties. The polymers will be used for the fabrication of a range of nanoparticles, which will allow to study the effect of architecture, composition and surface functionalisation on their behaviour in a biological environment. Carefully conducted structure-physicochemical property relationship and bio-nano interaction ....Expanding the toolbox of synthetic stealth polymers. This project aims to develop a new generation of synthetic and biomimetic pseudo peptide polymers with advanced biomedical properties. The polymers will be used for the fabrication of a range of nanoparticles, which will allow to study the effect of architecture, composition and surface functionalisation on their behaviour in a biological environment. Carefully conducted structure-physicochemical property relationship and bio-nano interaction studies will generate new knowledge in the area of stealth and protein repellent nanomaterials. The intended outcome of the project is the generation of a platform of bioinert materials that could potentially find applications as building blocks in next generation nanomedicines and medical devices.Read moreRead less
Advanced Fibre Interfaces in Active Water Management Systems. Flooding is a critical issue in Australia, generating considerable economic losses, including by stormwater contamination. The current project will pioneer an integrated solution for stormwater retention, while removing chemical pollutants. In collaboration with the company ROCKWOOL-Lapinus - based on a stonewool fibre platform - we will (i) design fibre coatings based on a versatile and chemically simple deposition process, (ii) inco ....Advanced Fibre Interfaces in Active Water Management Systems. Flooding is a critical issue in Australia, generating considerable economic losses, including by stormwater contamination. The current project will pioneer an integrated solution for stormwater retention, while removing chemical pollutants. In collaboration with the company ROCKWOOL-Lapinus - based on a stonewool fibre platform - we will (i) design fibre coatings based on a versatile and chemically simple deposition process, (ii) incorporate functionalities onto the fibres allowing active stormwater treatment to e.g. retain pollutants or target heavy metals and (iii) investigate these interfaces in-depth by advanced surface and interface characterisation methods to understand the fibre interface properties from nano- to macroscale.Read moreRead less
Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understandi ....Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understanding of how nanoparticle geometry affects particle-cell interaction and how nanoscale polymer discs can be used to mimic biological nanoparticles in shape and function.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100007
Funder
Australian Research Council
Funding Amount
$386,500.00
Summary
A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct ....A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct physicochemical properties will enable precise adjustment and investigation of discrete particle properties. The project will reshape fundamental knowledge of nanoparticle design by demonstrating the centrality of particle shape, stiffness, and heterogeneity. The outcomes will significantly advance the science of polymer nanoparticle synthesis control, aiding the development of novel and more effective polymer nano-therapeutics.Read moreRead less
Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailor ....Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailored towards bioactive and biocompatible material to create a drug delivery platform for more efficient disease treatment. The outcome will be better understanding on how polymer platelets can be obtained and how they compare in their biological activity with spherical nanoparticles.Read moreRead less
High performance inks for solution based organic light emitting diodes manufacturing. This project aims to introduce an advanced solution processing and printing technique for organic light emitting diode (OLED) fabrication based on a set of innovative macromolecular chemistries. These proceed either photochemically or thermally, exploiting precision macromolecular designs of the polymer precursor materials, which contain advanced emitter systems developed by Cynora. Solution fabrication of OLED ....High performance inks for solution based organic light emitting diodes manufacturing. This project aims to introduce an advanced solution processing and printing technique for organic light emitting diode (OLED) fabrication based on a set of innovative macromolecular chemistries. These proceed either photochemically or thermally, exploiting precision macromolecular designs of the polymer precursor materials, which contain advanced emitter systems developed by Cynora. Solution fabrication of OLED is a challenging, yet ultimately powerful, process with key advantages over current vacuum processing systems, especially with regard to production flexibility, cost and OLED size. The project will provide a functioning technology platform for solution OLED fabrication.Read moreRead less