Neuroprotective Functions Of Autophagy Regulators In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$434,644.00
Summary
The accumulation of the beta amyloid protein has a central role in AD and enhancing its removal improves memory loss in animal AD models. This project builds on my recent finding of regulators of a cell housekeeping system, “autophagy” which accelerate removal of beta amyloid in cells. This study will advance knowledge into the protective functions of the autophagy regulators in reducing AD symptoms. Findings from this work might provide the basis for developing effective anti-AD therapeutics.
Does Chronic Stress Drive Obesity And Type 2 Diabetes?
Funder
National Health and Medical Research Council
Funding Amount
$1,440,404.00
Summary
There is now good evidence that chronic stress, whether that be work stress or shift work can negatively impact on metabolic health and contribute to the development of obesity and type 2 diabetes. This proposal will explore the molecular mechanisms by which stress contributes to the development of obesity and type 2 diabetes. In particular we determine how stress affects the brain's ability to coordinate the utilisation of energy and nutrients.
Trafficking Mechanisms Governing Receptor Availability For Signalling
Funder
National Health and Medical Research Council
Funding Amount
$526,978.00
Summary
Receptors on the cell surface allow cells to respond to their environment. We have recently discovered a new pathway for controlling the amount of receptors displayed on the cell surface, errors within which will lead to defects in development and diseases like cancer. We are studying how this new pathway controls the balance between how much receptors are destroyed after being activated and how much are recycled back for re-use.